TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 527.415 | Formula: C27H23BrN6O
H donors: 2 H acceptors: 4 LogP: 5.41 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: Brc1ccc(cc1)C(=O)Nc1cccc(c1)CNc1ncnc2c1cnn2CCc1ccccc1
InChi: 1S/C27H23BrN6O/c28-22-11-9-21(10-12-22)27(35)33-23-8-4-7-20(15-23)16-29-25-24-17-32-34(26(24)31-18-30-25)14-13-19-5-2-1-3-6-19/h1-12,15,17-18H,13-14,16H2,(H,33,35)(H,29,30,31)
InChiKey: KEFIPKHDSKXZAY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ret proto-oncogene	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.1644	0.3788
Schistosoma mansoni	multidrug resistance protein	0.0014	0.0228	0.0252
Echinococcus granulosus	tubulin alpha chain	0.0035	0.1433	0.1581
Echinococcus granulosus	twitchin	0.0014	0.0229	0.0253
Trichomonas vaginalis	tubulin alpha chain, putative	0.0011	0.0033	0.0075
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0014	0.0228	0.0526
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0449	0.0449
Brugia malayi	Tubulin alpha chain	0.0035	0.1433	0.1433
Trichomonas vaginalis	tubulin gamma chain, putative	0.0019	0.0503	0.116
Schistosoma mansoni	tubulin subunit beta	0.0019	0.0503	0.0555
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0024	0.082	0.082
Echinococcus granulosus	roundabout 2	0.0018	0.044	0.0485
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0086	0.4339	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0035	0.1433	0.1581
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0144	0.767	0.8461
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.3177	0.3505
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Schistosoma mansoni	tubulin subunit epsilon	0.0019	0.0503	0.0555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0066	0.0153
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0086	0.4339	0.4786
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Echinococcus multilocularis	tubulin alpha chain	0.0035	0.1433	0.1581
Echinococcus multilocularis	tubulin alpha	0.0019	0.0503	0.0555
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0014	0.0228	0.0228
Echinococcus granulosus	peroxisome assembly protein 26	0.0035	0.1433	0.1581
Trypanosoma brucei	beta tubulin	0.0019	0.0503	0.1093
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.1846	1
Leishmania major	alpha tubulin	0.0035	0.1433	0.2931
Trypanosoma brucei	multidrug resistance protein E	0.0014	0.0228	0.0454
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.1846	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0019	0.0503	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0024	0.082	0.082
Echinococcus granulosus	tubulin alpha chain	0.0035	0.1433	0.1581
Onchocerca volvulus		0.0167	0.8988	0.9654
Echinococcus multilocularis	Tubulin beta 2C chain	0.0019	0.0503	0.0555
Leishmania major	alpha tubulin	0.0035	0.1433	0.2931
Echinococcus multilocularis	Tubulin beta 2C chain	0.0019	0.0503	0.0555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Entamoeba histolytica	tubulin gamma chain	0.0019	0.0503	0.116
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.0449	0.0967
Trypanosoma brucei	beta tubulin	0.0019	0.0503	0.1093
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.3177	0.3505
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.1846	0.4254
Echinococcus granulosus	Tubulin beta 2C chain	0.0019	0.0503	0.0555
Echinococcus granulosus	defective proboscis extension response	0.0011	0.0064	0.0071
Schistosoma mansoni	tubulin subunit alpha	0.0035	0.1433	0.1581
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0011	0.0064	0.0071
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.3177	0.3177
Echinococcus granulosus	tubulin subunit beta	0.0019	0.0503	0.0555
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0018	0.0449	0.1034
Trypanosoma brucei	p-glycoprotein	0.0014	0.0228	0.0454
Echinococcus multilocularis	peroxisome assembly protein 26	0.0035	0.1433	0.1581
Schistosoma mansoni	multidrug resistance protein	0.0014	0.0228	0.0252
Leishmania major	alpha tubulin	0.0035	0.1433	0.2931
Brugia malayi	ABC transporter transmembrane region family protein	0.0014	0.0228	0.0228
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0064	0.0071
Schistosoma mansoni	alpha tubulin	0.0035	0.1433	0.1581
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0014	0.0228	0.0526
Onchocerca volvulus	Tyrosine kinase homolog	0.0172	0.9309	1
Plasmodium vivax	tubulin alpha chain, putative	0.0035	0.1433	0.6926
Brugia malayi	alpha-tubulin	0.0035	0.1433	0.1433
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0018	0.0449	0.0495
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0011	0.0064	0.0064
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0025	0.0833	0.0919
Loa Loa (eye worm)	BEN-1 protein	0.0019	0.0503	0.0503
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0449	0.0449
Echinococcus multilocularis	tubulin alpha chain	0.0035	0.1433	0.1581
Giardia lamblia	Alpha-tubulin	0.0035	0.1433	0.2942
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0086	0.4339	0.4786
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0018	0.0449	0.1034
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Trypanosoma brucei	alpha tubulin	0.0035	0.1433	0.3252
Echinococcus granulosus	tubulin alpha 1C chain	0.0035	0.1433	0.1581
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0019	0.0503	0.2455
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Plasmodium falciparum	alpha tubulin 1	0.0035	0.1433	0.8153
Brugia malayi	tubulin alpha-2 chain	0.0035	0.1433	0.1433
Echinococcus granulosus	tubulin alpha	0.0019	0.0503	0.0555
Brugia malayi	acetyltransferase, GNAT family protein	0.0144	0.767	0.767
Trypanosoma cruzi	target of rapamycin kinase 3	0.0018	0.0449	0.1034
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0027	0.0962	0.0962
Brugia malayi	Tubulin beta chain	0.0011	0.0033	0.0033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Loa Loa (eye worm)	tubulin alpha 2	0.0016	0.0349	0.0349
Brugia malayi	Tubulin beta-1 chain	0.0019	0.0503	0.0503
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0014	0.0228	0.0526
Giardia lamblia	Multidrug resistance-associated protein 1	0.0014	0.0228	0.0016
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0014	0.0228	0.0454
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Echinococcus multilocularis	neuroglian	0.0014	0.0229	0.0253
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.2023	0.2232
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0064	0.0064
Loa Loa (eye worm)	BEN-1 protein	0.0019	0.0503	0.0503
Echinococcus granulosus	beta tubulin	0.0019	0.0503	0.0555
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0018	0.0451	0.0542
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0833	0.1921
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0014	0.0228	0.0526
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.3177	0.3505
Schistosoma mansoni	hypothetical protein	0.0168	0.9065	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0035	0.1433	0.1581
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Entamoeba histolytica	hypothetical protein, conserved	0.0086	0.4339	1
Schistosoma mansoni	tubulin subunit beta	0.0019	0.0503	0.0555
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0086	0.4339	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.3177	0.7322
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Toxoplasma gondii	alpha tubulin TUBA1	0.0035	0.1433	0.768
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.1595	0.1759
Echinococcus granulosus	histone acetyltransferase KAT2B	0.014	0.7439	0.8206
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0066	0.0153
Echinococcus multilocularis	tubulin alpha chain	0.0035	0.1433	0.1581
Echinococcus multilocularis	Tubulin beta 2C chain	0.0019	0.0503	0.0555
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0222	0.0222
Loa Loa (eye worm)	tubulin beta chain	0.0019	0.0503	0.0503
Loa Loa (eye worm)	multidrug resistance-associated protein	0.0011	0.0047	0.0047
Trypanosoma cruzi	epsilon tubulin, putative	0.0019	0.0503	0.116
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trypanosoma brucei	alpha tubulin	0.0035	0.1433	0.3252
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0962	0.0962
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0035	0.1433	0.1581
Leishmania major	alpha tubulin	0.0035	0.1433	0.2931
Leishmania major	alpha tubulin	0.0035	0.1433	0.2931
Trypanosoma brucei	alpha tubulin	0.0035	0.1433	0.3252
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Entamoeba histolytica	ABC transporter, putative	0.0014	0.0228	0.0526
Schistosoma mansoni	cell adhesion molecule	0.0015	0.0275	0.0303
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0018	0.0451	0.1039
Echinococcus multilocularis	tubulin alpha chain	0.0035	0.1433	0.1581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0019	0.0503	0.116
Trypanosoma cruzi	hypothetical protein	0.0011	0.004	0.0093
Loa Loa (eye worm)	tubulin beta-4 chain	0.0019	0.0503	0.0503
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Schistosoma mansoni	multidrug resistance protein	0.0014	0.0228	0.0252
Schistosoma mansoni	tubulin subunit beta	0.0019	0.0503	0.0555
Leishmania major	alpha tubulin	0.0035	0.1433	0.2931
Leishmania major	alpha tubulin	0.0035	0.1433	0.2931
Echinococcus granulosus	Tubulin beta 2C chain	0.0019	0.0503	0.0555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.4339	1
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0014	0.0228	0.0252
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Trichomonas vaginalis	tubulin alpha chain, putative	0.0011	0.0033	0.0075
Echinococcus granulosus	tubulin alpha 3 chain	0.0035	0.1433	0.1581
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0064	0.0064
Echinococcus multilocularis	tubulin alpha 1C chain	0.0035	0.1433	0.1581
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Schistosoma mansoni	hypothetical protein	0.0086	0.4339	0.4786
Echinococcus multilocularis	tubulin beta 1 chain	0.0019	0.0503	0.0555
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0449	0.0449
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.3177	0.3177
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0228	0.0228
Echinococcus granulosus	tubulin subunit TubB	0.0035	0.1433	0.1581
Echinococcus multilocularis	tubulin alpha 3 chain	0.0035	0.1433	0.1581
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0066	0.0066
Giardia lamblia	Rrm3p helicase	0.0086	0.4339	1
Giardia lamblia	MRP-like ABC transporter	0.0014	0.0228	0.0016
Trypanosoma cruzi	epsilon tubulin, putative	0.0019	0.0503	0.116
Trypanosoma brucei	epsilon tubulin	0.0019	0.0503	0.1093
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0018	0.0449	0.1034
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0014	0.0228	0.0526
Echinococcus granulosus	Tubulin beta 2C chain	0.0019	0.0503	0.0555
Loa Loa (eye worm)	tubulin alpha chain	0.0035	0.1433	0.1433
Loa Loa (eye worm)	tubulin beta-2A chain	0.0019	0.0503	0.0503
Trypanosoma brucei	beta tubulin	0.0019	0.0503	0.1093
Echinococcus granulosus	tubulin alpha chain	0.0035	0.1433	0.1581
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Echinococcus granulosus	Tubulin beta 2C chain	0.0019	0.0503	0.0555
Schistosoma mansoni	multidrug resistance protein	0.0014	0.0228	0.0252
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.2023	0.2232
Echinococcus multilocularis	Tubulin beta 2C chain	0.0019	0.0503	0.0555
Entamoeba histolytica	tubulin family protein	0.0019	0.0503	0.116
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0014	0.0228	0.0526
Entamoeba histolytica	tubulin family protein	0.0019	0.0503	0.116
Trichomonas vaginalis	tubulin, putative	0.0011	0.0033	0.0075
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0449	0.1034
Giardia lamblia	ABC transporter, putative	0.0014	0.0228	0.0016
Trypanosoma brucei	epsilon tubulin	0.0019	0.0503	0.1093
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0018	0.0449	0.0537
Brugia malayi	Tubulin alpha-2 chain	0.0035	0.1433	0.1433
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0086	0.4339	1
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0086	0.4339	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trypanosoma cruzi	tubulin gamma chain	0.0019	0.0503	0.116
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0035	0.1433	0.3302
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0011	0.0033	0.0075
Brugia malayi	Fibronectin type III domain containing protein	0.0011	0.0064	0.0064
Echinococcus granulosus	tubulin alpha chain	0.0035	0.1433	0.1581
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.2023	0.2232
Entamoeba histolytica	tubulin alpha chain, putative	0.0035	0.1433	0.3302
Trichomonas vaginalis	tubulin beta chain, putative	0.0035	0.1433	0.3302
Schistosoma mansoni	nephrin	0.0014	0.0229	0.0253
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0011	0.0064	0.0071
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0018	0.0449	0.0537
Echinococcus granulosus	geminin	0.0168	0.9065	1
Leishmania major	gamma-tubulin	0.0019	0.0503	0.0669
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.1595	0.1759
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0086	0.4339	1
Loa Loa (eye worm)	alpha-tubulin	0.0035	0.1433	0.1433
Echinococcus granulosus	tubulin alpha 1C chain	0.0035	0.1433	0.1581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Echinococcus granulosus	Tubulin alpha 1 chain	0.0035	0.1433	0.1581
Loa Loa (eye worm)	acetyltransferase	0.0144	0.767	0.767
Echinococcus granulosus	Tubulin beta 2C chain	0.0019	0.0503	0.0555
Trichomonas vaginalis	tubulin alpha chain, putative	0.0019	0.0503	0.116
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0035	0.1433	0.1581
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0018	0.0449	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0018	0.044	0.044
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0144	0.767	0.8461
Leishmania major	alpha tubulin	0.0035	0.1433	0.2931
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0021	0.0635	0.1464
Entamoeba histolytica	hypothetical protein	0.0014	0.0228	0.0526
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trichomonas vaginalis	tubulin beta chain, putative	0.0035	0.1433	0.3302
Toxoplasma gondii	FATC domain-containing protein	0.0025	0.0833	0.4311
Leishmania major	alpha tubulin	0.0035	0.1433	0.2931
Echinococcus multilocularis	tubulin epsilon chain	0.0019	0.0503	0.0555
Trichomonas vaginalis	tubulin gamma chain, putative	0.0019	0.0503	0.116
Echinococcus granulosus	tubulin gamma 1 chain	0.0019	0.0503	0.0555
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0018	0.0449	0.0495
Echinococcus granulosus	beta tubulin	0.0019	0.0503	0.0555
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0018	0.0449	0.0967
Brugia malayi	hypothetical protein	0.0011	0.0064	0.0064
Schistosoma mansoni	alpha tubulin	0.0035	0.1433	0.1581
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0184	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0449	0.1034
Schistosoma mansoni	alpha tubulin	0.0035	0.1433	0.1581
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0018	0.0449	0.0537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trypanosoma cruzi	beta tubulin, putative	0.0019	0.0503	0.116
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.3177	0.7302
Schistosoma mansoni	tubulin subunit beta	0.0019	0.0503	0.0555
Loa Loa (eye worm)	beta-tubulin	0.0019	0.0503	0.0503
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.1846	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0014	0.0228	0.0252
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0025	0.0833	0.1921
Loa Loa (eye worm)	tubulin alpha chain	0.0035	0.1433	0.1433
Echinococcus granulosus	tubulin epsilon chain	0.0019	0.0503	0.0555
Schistosoma mansoni	tubulin subunit alpha	0.0035	0.1433	0.1581
Echinococcus granulosus	Immunoglobulin	0.0011	0.0064	0.0071
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.0449	0.0967
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0011	0.0066	0.0078
Echinococcus granulosus	Tubulin alpha 1 chain	0.0035	0.1433	0.1581
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0064	0.0064
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.2023	0.2232
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.2023	0.2232
Leishmania major	alpha tubulin	0.0035	0.1433	0.2931
Trichomonas vaginalis	tubulin gamma chain, putative	0.0019	0.0503	0.116
Trypanosoma brucei	tubulin gamma chain	0.0019	0.0503	0.1093
Echinococcus multilocularis	roundabout 2	0.0018	0.044	0.0485
Echinococcus granulosus	serine protein kinase ATM	0.0025	0.0833	0.0919
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Leishmania major	alpha tubulin	0.0035	0.1433	0.2931
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0014	0.0228	0.091
Trichomonas vaginalis	tubulin alpha chain, putative	0.0019	0.0503	0.116
Schistosoma mansoni	vesicular amine transporter	0.0011	0.0064	0.0071
Echinococcus multilocularis	serine protein kinase ATM	0.0025	0.0833	0.0919
Brugia malayi	tubulin alpha chain - mouse	0.0035	0.1433	0.1433
Echinococcus multilocularis	Tubulin beta 2C chain	0.0019	0.0503	0.0555
Schistosoma mansoni	hypothetical protein	0.0168	0.9065	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0228	0.0228
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0064	0.0064
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0014	0.0228	0.0526
Trypanosoma brucei	alpha tubulin	0.0035	0.1433	0.3252
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.1644	0.3453
Toxoplasma gondii	beta-1 tubulin, putative	0.0019	0.0503	0.2455
Loa Loa (eye worm)	tubulin gamma chain	0.0019	0.0503	0.0503
Echinococcus multilocularis	multidrug resistance associated protein 4	0.0011	0.004	0.0045
Echinococcus multilocularis	geminin	0.0168	0.9065	1
Leishmania major	epsilon tubulin, putative	0.0019	0.0503	0.0669
Echinococcus granulosus	multidrug resistance associated protein 1	0.0014	0.0228	0.0252
Loa Loa (eye worm)	alpha-tubulin	0.0035	0.1433	0.1433
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.2023	0.2232
Schistosoma mansoni	tubulin subunit gamma	0.0019	0.0503	0.0555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.3177	0.7322
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0027	0.0962	0.2218
Giardia lamblia	Gamma tubulin	0.0019	0.0503	0.0683
Loa Loa (eye worm)	tubulin beta-1 chain	0.0019	0.0503	0.0503
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0014	0.0228	0.0454
Trypanosoma brucei	beta tubulin	0.0019	0.0503	0.1093
Echinococcus multilocularis	tubulin subunit TubB	0.0035	0.1433	0.1581
Brugia malayi	beta-tubulin, identical	0.0019	0.0503	0.0503
Schistosoma mansoni	tubulin subunit beta	0.0019	0.0503	0.0555
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0449	0.0495
Loa Loa (eye worm)	tubulin alpha 2	0.0027	0.0962	0.0962
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0064	0.0071
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0035	0.1433	0.1433
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0018	0.0449	0.0967
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0018	0.0449	0.215
Schistosoma mansoni	tubulin subunit beta	0.0019	0.0503	0.0555
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.1846	0.2036
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1433	0.1433
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Leishmania major	alpha tubulin	0.0035	0.1433	0.2931
Echinococcus multilocularis	beta tubulin	0.0019	0.0503	0.0555
Trichomonas vaginalis	tubulin beta chain, putative	0.0035	0.1433	0.3302
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0024	0.082	0.1889
Echinococcus granulosus	tubulin alpha 3 chain	0.0035	0.1433	0.1581
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0275	0.0303
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.3177	0.7173
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Echinococcus granulosus	alpha tubulin	0.0035	0.1433	0.1581
Brugia malayi	Tubulin gamma chain	0.0019	0.0503	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0018	0.044	0.044
Trypanosoma cruzi	alpha tubulin, putative	0.0035	0.1433	0.3302
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0449	0.0449
Trichomonas vaginalis	tubulin, putative	0.0011	0.0033	0.0075
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.1846	0.4254
Giardia lamblia	GTOR	0.0018	0.0449	0.0552
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.1644	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0014	0.0228	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.2023	0.2023
Toxoplasma gondii	alpha-tubulin I, putative	0.0035	0.1433	0.768
Echinococcus granulosus	tubulin beta 4A class IVa	0.0019	0.0503	0.0555
Echinococcus multilocularis	beta tubulin	0.0019	0.0503	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0275	0.0275
Toxoplasma gondii	beta-tubulin, putative	0.0019	0.0503	0.2455
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.3177	0.7322
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0086	0.4339	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0449	0.0495
Echinococcus granulosus	tubulin alpha chain	0.0035	0.1433	0.1581
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0018	0.0449	0.0967
Echinococcus multilocularis	tubulin gamma 1 chain	0.0019	0.0503	0.0555
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0019	0.0503	0.116
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0035	0.1433	0.3302
Plasmodium falciparum	alpha tubulin 2	0.0035	0.1433	0.8153
Echinococcus multilocularis	tubulin alpha 1C chain	0.0035	0.1433	0.1581
Loa Loa (eye worm)	tubulin alpha 2	0.0027	0.0962	0.0962
Echinococcus multilocularis	hypothetical protein	0.0035	0.1433	0.1581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Echinococcus granulosus	multidrug resistance associated protein 4	0.0011	0.004	0.0045
Schistosoma mansoni	tubulin subunit alpha	0.0035	0.1433	0.1581
Echinococcus multilocularis	tubulin alpha chain	0.0035	0.1433	0.1581
Echinococcus multilocularis	tubulin subunit beta	0.0019	0.0503	0.0555
Entamoeba histolytica	tubulin alpha-1 chain	0.0035	0.1433	0.3302
Echinococcus granulosus	tubulin beta 1 chain	0.0019	0.0503	0.0555
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0025	0.0833	0.186
Trichomonas vaginalis	tubulin alpha chain, putative	0.0011	0.0033	0.0075
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0086	0.4339	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0018	0.0449	0.1034
Brugia malayi	Tubulin alpha-2 chain	0.0035	0.1433	0.1433
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0035	0.1433	0.3302
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0086	0.4339	1
Giardia lamblia	Alpha-tubulin	0.0035	0.1433	0.2942
Echinococcus granulosus	multidrug resistance associated protein 7	0.0014	0.0228	0.0252
Entamoeba histolytica	multidrug resistance protein, putative	0.0014	0.0228	0.0526
Trypanosoma brucei	beta tubulin	0.0019	0.0503	0.1093
Giardia lamblia	Beta tubulin	0.0019	0.0503	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0635	0.0635
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.2023	0.2232
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0449	0.0495
Trichomonas vaginalis	tubulin beta chain, putative	0.0035	0.1433	0.3302
Brugia malayi	multidrug resistance related protein 1	0.0014	0.0228	0.0228
Trichomonas vaginalis	tubulin beta chain, putative	0.0011	0.0033	0.0075
Trichomonas vaginalis	tubulin beta chain, putative	0.0035	0.1433	0.3302
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0011	0.0064	0.0071
Echinococcus granulosus	neuroglian	0.0014	0.0229	0.0253
Giardia lamblia	Beta tubulin	0.0019	0.0503	0.0683
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Trypanosoma brucei	epsilon tubulin	0.0019	0.0503	0.1093
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.2023	0.2023
Plasmodium vivax	tubulin alpha chain, putative	0.0035	0.1433	0.6926
Giardia lamblia	Beta tubulin	0.0019	0.0503	0.0683
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0833	0.0833
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0018	0.0449	0.0495
Trichomonas vaginalis	tubulin beta chain, putative	0.0035	0.1433	0.3302
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0449	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0064	0.0064
Toxoplasma gondii	beta tubulin	0.0019	0.0503	0.2455
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0018	0.0449	0.0537
Entamoeba histolytica	hypothetical protein	0.0025	0.0833	0.1921
Trichomonas vaginalis	tubulin, putative	0.0019	0.0503	0.116
Leishmania major	beta tubulin	0.0019	0.0503	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0064	0.0064
Trichomonas vaginalis	tubulin beta chain, putative	0.0019	0.0503	0.116
Echinococcus multilocularis	tubulin alpha 3 chain	0.0035	0.1433	0.1581

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.48 uM	Inhibition of recombinant human VEGFR2 incubated for 5 mins with substrate prior to protein addition by fluorescence assay	ChEMBL.	24447248
IC50 (binding)	= 4.26 uM	Inhibition of recombinant human RET incubated for 5 mins with substrate prior to protein addition by fluorescence assay	ChEMBL.	24447248
IC50 (functional)	= 13.48 uM	Antiproliferative activity against human TT cells after 72 hrs by cell counter	ChEMBL.	24447248

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24447248

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3128229

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1828787