Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium-sensing receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1553 | 0.1553 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0251 | 0.1553 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0251 | 0.1553 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0251 | 0.1553 | 0.1519 |
Onchocerca volvulus | 0.0251 | 0.1553 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0251 | 0.1553 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0251 | 0.1553 | 0.1553 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0251 | 0.1553 | 0.1553 |
Loa Loa (eye worm) | carboxylesterase | 0.1483 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0251 | 0.1553 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0251 | 0.1553 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1483 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.1553 | 0.1519 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0251 | 0.1553 | 0.1553 |
Onchocerca volvulus | 0.0251 | 0.1553 | 0.5 | |
Schistosoma mansoni | metabotropic glutamate receptor | 0.02 | 0.1206 | 0.1206 |
Echinococcus granulosus | acetylcholinesterase | 0.1483 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1483 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0251 | 0.1553 | 0.1519 |
Brugia malayi | Carboxylesterase family protein | 0.1483 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.1553 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1553 | 0.1553 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.1553 | 0.1519 |
Loa Loa (eye worm) | carboxylesterase | 0.0251 | 0.1553 | 0.1553 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.1553 | 0.1519 |
Onchocerca volvulus | 0.0251 | 0.1553 | 0.5 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0251 | 0.1553 | 0.1519 |
Schistosoma mansoni | acetylcholinesterase | 0.0251 | 0.1553 | 0.1553 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1483 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0251 | 0.1553 | 0.1553 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0251 | 0.1553 | 0.1519 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1483 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1483 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0039 | 0.0039 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0251 | 0.1553 | 0.1519 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0251 | 0.1553 | 0.1553 |
Echinococcus granulosus | acetylcholinesterase | 0.1483 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1553 | 0.1553 |
Echinococcus granulosus | carboxylesterase 5A | 0.1483 | 1 | 1 |
Onchocerca volvulus | 0.0251 | 0.1553 | 0.5 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0251 | 0.1553 | 0.1519 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1483 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0251 | 0.1553 | 0.1553 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0251 | 0.1553 | 0.1519 |
Onchocerca volvulus | 0.0251 | 0.1553 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0251 | 0.1553 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1553 | 0.1553 |
Schistosoma mansoni | gliotactin | 0.0251 | 0.1553 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1553 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1553 | 0.1553 |
Echinococcus granulosus | neuroligin | 0.0251 | 0.1553 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.1483 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0251 | 0.1553 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1553 | 0.1553 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 19 nM | Activation of human CaSR | ChEMBL. | 24215889 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.