Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium-sensing receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma mansoni | metabotropic glutamate receptor | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1097 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1097 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1097 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1097 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1097 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1097 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0131 | 0.0131 |
Trypanosoma brucei | protein kinase, putative | 0.1097 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1097 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1097 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1097 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1097 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1097 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1097 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1097 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1097 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1097 | 1 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.003 | 0.0131 | 0.0131 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1097 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1097 | 1 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.02 | 0.1705 | 0.1641 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1097 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1097 | 1 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0024 | 0.0077 | 0.0077 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 9 nM | Activation of human CaSR | ChEMBL. | 24215889 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.