Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (binding) | Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production at 2000 nM after 24 hrs relative to control | ChEMBL. | 24215891 | |
IC50 (binding) | Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 24 hrs | ChEMBL. | 24215891 | |
IC50 (binding) | = 170 nM | Binding affinity to mineralocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay | ChEMBL. | 24215891 |
IC50 (binding) | > 10000 nM | Displacement of TAMRA-labeled dexamethasone from glucocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay | ChEMBL. | 24215891 |
IC50 (binding) | > 10000 nM | Displacement of TAMRA-labeled mifepristone from progesterone receptor (unknown origin) by fluorescence polarization competitive binding assay | ChEMBL. | 24215891 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.