Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0274 | 0.0902 | 0.2351 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.016 | 0.0139 | 0.0152 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0228 | 0.0596 | 0.0531 |
Schistosoma mansoni | alpha tubulin | 0.0228 | 0.0596 | 0.0531 |
Schistosoma mansoni | tubulin subunit beta | 0.0274 | 0.0902 | 0.0872 |
Echinococcus granulosus | beta tubulin | 0.0274 | 0.0902 | 0.0872 |
Schistosoma mansoni | tubulin subunit beta | 0.0274 | 0.0902 | 0.0872 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0228 | 0.0596 | 0.1554 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0354 | 0.1443 | 0.1587 |
Loa Loa (eye worm) | alpha-tubulin | 0.0228 | 0.0596 | 0.0655 |
Trypanosoma brucei | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Loa Loa (eye worm) | BEN-1 protein | 0.0274 | 0.0902 | 0.0992 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0274 | 0.0902 | 0.0872 |
Echinococcus multilocularis | beta tubulin | 0.0274 | 0.0902 | 0.0872 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0228 | 0.0596 | 0.1554 |
Trypanosoma brucei | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0274 | 0.0902 | 0.0992 |
Brugia malayi | Tubulin alpha-2 chain | 0.0228 | 0.0596 | 0.0531 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0228 | 0.0596 | 0.6088 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0274 | 0.0902 | 0.0872 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0228 | 0.0596 | 0.0531 |
Leishmania major | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Brugia malayi | tubulin alpha-2 chain | 0.0228 | 0.0596 | 0.0531 |
Echinococcus granulosus | tubulin subunit beta | 0.0274 | 0.0902 | 0.0872 |
Schistosoma mansoni | tubulin subunit alpha | 0.0228 | 0.0596 | 0.0531 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0228 | 0.0596 | 0.0531 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1495 | 0.9091 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0274 | 0.0902 | 0.0872 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0274 | 0.0902 | 0.0872 |
Echinococcus granulosus | tubulin subunit TubB | 0.0228 | 0.0596 | 0.0531 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0274 | 0.0902 | 0.0872 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.163 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0228 | 0.0596 | 0.0531 |
Echinococcus multilocularis | beta tubulin | 0.0274 | 0.0902 | 0.0872 |
Plasmodium vivax | tubulin beta chain, putative | 0.0274 | 0.0902 | 0.0792 |
Mycobacterium ulcerans | thymidylate synthase | 0.1495 | 0.9091 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0228 | 0.0596 | 0.0531 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.163 | 1 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0274 | 0.0902 | 0.0872 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Brugia malayi | beta-tubulin, identical | 0.0274 | 0.0902 | 0.0872 |
Schistosoma mansoni | tubulin subunit beta | 0.0274 | 0.0902 | 0.0872 |
Entamoeba histolytica | tubulin family protein | 0.0274 | 0.0902 | 1 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0228 | 0.0596 | 0.0655 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0274 | 0.0902 | 0.2351 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0711 | 0.3836 | 0.3761 |
Brugia malayi | tubulin alpha chain - mouse | 0.0228 | 0.0596 | 0.0531 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1495 | 0.9091 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1495 | 0.9091 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0228 | 0.0596 | 0.0531 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0228 | 0.0596 | 0.0531 |
Leishmania major | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Brugia malayi | Dihydrofolate reductase | 0.0354 | 0.1443 | 0.1475 |
Schistosoma mansoni | tubulin subunit beta | 0.0274 | 0.0902 | 0.0872 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0157 | 0.012 | 0.0312 |
Echinococcus granulosus | dihydrofolate reductase | 0.0354 | 0.1443 | 0.1475 |
Leishmania major | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Echinococcus granulosus | alpha tubulin | 0.0228 | 0.0596 | 0.0531 |
Giardia lamblia | Beta tubulin | 0.0274 | 0.0902 | 1 |
Plasmodium falciparum | alpha tubulin 2 | 0.0228 | 0.0596 | 0.0482 |
Echinococcus granulosus | tubulin alpha chain | 0.0228 | 0.0596 | 0.0531 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0157 | 0.012 | 0.0312 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0241 | 0.0681 | 0.0569 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0228 | 0.0596 | 0.0531 |
Brugia malayi | Tubulin alpha-2 chain | 0.0228 | 0.0596 | 0.0531 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0274 | 0.0902 | 0.2351 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0157 | 0.012 | 0.0312 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0274 | 0.0902 | 0.0872 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0157 | 0.012 | 0.0132 |
Schistosoma mansoni | dihydrofolate reductase | 0.0354 | 0.1443 | 0.1475 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0228 | 0.0596 | 0.0482 |
Echinococcus multilocularis | tubulin alpha chain | 0.0228 | 0.0596 | 0.0531 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.163 | 1 | 1 |
Onchocerca volvulus | 0.1495 | 0.9091 | 0.5 | |
Echinococcus granulosus | thymidylate synthase | 0.1495 | 0.9091 | 1 |
Brugia malayi | thymidylate synthase | 0.1495 | 0.9091 | 1 |
Giardia lamblia | Alpha-tubulin | 0.0228 | 0.0596 | 0.6088 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.016 | 0.0139 | 0.0152 |
Trypanosoma brucei | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0241 | 0.0681 | 0.075 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Leishmania major | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Echinococcus multilocularis | tubulin alpha chain | 0.0228 | 0.0596 | 0.0531 |
Leishmania major | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0354 | 0.1443 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0241 | 0.0681 | 0.0626 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.016 | 0.0139 | 0.0361 |
Echinococcus granulosus | carbonic anhydrase II | 0.0241 | 0.0681 | 0.0626 |
Brugia malayi | Tubulin beta-1 chain | 0.0274 | 0.0902 | 0.0872 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1495 | 0.9091 | 1 |
Giardia lamblia | Beta tubulin | 0.0274 | 0.0902 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0228 | 0.0596 | 0.1554 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0228 | 0.0596 | 0.0482 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Echinococcus granulosus | tubulin alpha chain | 0.0228 | 0.0596 | 0.0531 |
Leishmania major | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0228 | 0.0596 | 0.0531 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0711 | 0.3836 | 0.3128 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0228 | 0.0596 | 0.0655 |
Leishmania major | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0228 | 0.0596 | 0.0531 |
Toxoplasma gondii | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0228 | 0.0596 | 0.0531 |
Schistosoma mansoni | alpha tubulin | 0.0228 | 0.0596 | 0.0531 |
Echinococcus multilocularis | hypothetical protein | 0.0228 | 0.0596 | 0.0531 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0274 | 0.0902 | 0.0872 |
Loa Loa (eye worm) | tubulin beta chain | 0.0274 | 0.0902 | 0.0992 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0274 | 0.0902 | 0.0872 |
Toxoplasma gondii | beta-tubulin, putative | 0.0274 | 0.0902 | 0.0792 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0228 | 0.0596 | 0.1554 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.016 | 0.0139 | 0.0152 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Brugia malayi | dihydrofolate reductase family protein | 0.0354 | 0.1443 | 0.1475 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0228 | 0.0596 | 0.0482 |
Plasmodium falciparum | alpha tubulin 1 | 0.0228 | 0.0596 | 0.0482 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0228 | 0.0596 | 0.1554 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0354 | 0.1443 | 0.1475 |
Brugia malayi | alpha-tubulin | 0.0228 | 0.0596 | 0.0531 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0274 | 0.0902 | 0.0872 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0274 | 0.0902 | 0.0872 |
Echinococcus multilocularis | tubulin alpha chain | 0.0228 | 0.0596 | 0.0531 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0274 | 0.0902 | 0.0872 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0228 | 0.0596 | 0.6088 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0228 | 0.0596 | 0.0531 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0228 | 0.0596 | 0.0531 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0228 | 0.0596 | 0.1554 |
Leishmania major | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0228 | 0.0596 | 0.1554 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.163 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0274 | 0.0902 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0274 | 0.0902 | 0.0992 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0241 | 0.0681 | 0.0626 |
Trypanosoma brucei | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Trypanosoma cruzi | beta tubulin, putative | 0.0274 | 0.0902 | 0.0792 |
Trichomonas vaginalis | tubulin, putative | 0.0274 | 0.0902 | 0.2351 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0228 | 0.0596 | 0.1554 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0241 | 0.0681 | 0.0626 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0241 | 0.0681 | 0.075 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0274 | 0.0902 | 0.0872 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0241 | 0.0681 | 0.0626 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0274 | 0.0902 | 0.0992 |
Trypanosoma brucei | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Echinococcus granulosus | tubulin alpha chain | 0.0228 | 0.0596 | 0.0531 |
Schistosoma mansoni | tubulin subunit beta | 0.0274 | 0.0902 | 0.0872 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Leishmania major | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Echinococcus multilocularis | tubulin alpha chain | 0.0228 | 0.0596 | 0.0531 |
Echinococcus granulosus | tubulin alpha chain | 0.0228 | 0.0596 | 0.0531 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.163 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0228 | 0.0596 | 0.0531 |
Loa Loa (eye worm) | BEN-1 protein | 0.0274 | 0.0902 | 0.0992 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0274 | 0.0902 | 0.0872 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0228 | 0.0596 | 0.0482 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0274 | 0.0902 | 0.2351 |
Brugia malayi | hypothetical protein | 0.0711 | 0.3836 | 0.4142 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0274 | 0.0902 | 0.2351 |
Schistosoma mansoni | tubulin subunit alpha | 0.0228 | 0.0596 | 0.0531 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0711 | 0.3836 | 1 |
Leishmania major | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Leishmania major | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Leishmania major | carbonic anhydrase-like protein | 0.0241 | 0.0681 | 0.0569 |
Loa Loa (eye worm) | alpha-tubulin | 0.0228 | 0.0596 | 0.0655 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Plasmodium falciparum | tubulin beta chain | 0.0274 | 0.0902 | 0.0792 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0274 | 0.0902 | 0.0792 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0241 | 0.0681 | 0.0569 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0241 | 0.0681 | 0.0569 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0228 | 0.0596 | 0.0531 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0228 | 0.0596 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.0596 | 0.0655 |
Loa Loa (eye worm) | thymidylate synthase | 0.1495 | 0.9091 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0228 | 0.0596 | 0.1554 |
Brugia malayi | Tubulin alpha chain | 0.0228 | 0.0596 | 0.0531 |
Schistosoma mansoni | alpha tubulin | 0.0228 | 0.0596 | 0.0531 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0274 | 0.0902 | 0.0992 |
Leishmania major | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Echinococcus granulosus | beta tubulin | 0.0274 | 0.0902 | 0.0872 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0228 | 0.0596 | 0.0531 |
Giardia lamblia | Alpha-tubulin | 0.0228 | 0.0596 | 0.6088 |
Schistosoma mansoni | tubulin subunit alpha | 0.0228 | 0.0596 | 0.0531 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0228 | 0.0596 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.0139 | 0.0152 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Echinococcus multilocularis | tubulin subunit beta | 0.0274 | 0.0902 | 0.0872 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0274 | 0.0902 | 0.0872 |
Trypanosoma brucei | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Echinococcus multilocularis | tubulin alpha chain | 0.0228 | 0.0596 | 0.0531 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0228 | 0.0596 | 0.0482 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0241 | 0.0681 | 0.0626 |
Giardia lamblia | Beta tubulin | 0.0274 | 0.0902 | 1 |
Leishmania major | beta tubulin | 0.0274 | 0.0902 | 0.0792 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0228 | 0.0596 | 0.0531 |
Trypanosoma brucei | alpha tubulin | 0.0228 | 0.0596 | 0.0482 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1000 uM | In vitro inhibition of human Cyclophillin A/protein interaction. | ChEMBL. | 12431052 |
IC50 (binding) | = 1000 uM | 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay | ChEMBL. | 10794694 |
Inhibition (binding) | = 13 % | % inhibition of competitive binding, at 500uM, against human Peptidyl-prolyl isomerase | ChEMBL. | 10794694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.