Detailed information for compound 1829710

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 519.552 | Formula: C26H29N7O5
  • H donors: 2 H acceptors: 6 LogP: 2.26 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCc1cc(n(n1)CC)C(=O)N[C@@H]1C[C@H](N(C1)C(=O)c1coc2c1cccc2)C(=O)NCc1onc(n1)C
  • InChi: 1S/C26H29N7O5/c1-4-16-10-21(33(5-2)30-16)25(35)29-17-11-20(24(34)27-12-23-28-15(3)31-38-23)32(13-17)26(36)19-14-37-22-9-7-6-8-18(19)22/h6-10,14,17,20H,4-5,11-13H2,1-3H3,(H,27,34)(H,29,35)/t17-,20+/m1/s1
  • InChiKey: NRESEDOZLJDOMX-XLIONFOSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii enoyl-acyl carrier reductase ENR Get druggable targets OG5_130466 All targets in OG5_130466
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium falciparum enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Neospora caninum enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium knowlesi enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Trichomonas vaginalis hypothetical protein Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium vivax enoyl-acyl carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium berghei enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium yoelii enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) Get druggable targets OG5_130466 All targets in OG5_130466
Chlamydia trachomatis enoyl-acyl-carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0017 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0017 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0 0.5
Brugia malayi hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0 0.5
Schistosoma mansoni hypothetical protein 0.0017 0 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0 0.5
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0223 1 0.5
Onchocerca volvulus 0.0017 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0 0.5
Echinococcus granulosus allatostatin A receptor 0.0017 0 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0017 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0017 0 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus granulosus serotonin receptor 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0223 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0 0.5
Echinococcus multilocularis orexin receptor type 2 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Schistosoma mansoni hypothetical protein 0.0017 0 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0 0.5
Schistosoma mansoni opsin-like receptor 0.0017 0 0.5
Brugia malayi Dopamine receptor protein 1 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0017 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0017 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0017 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0017 0 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Schistosoma mansoni amine GPCR 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0 0.5
Brugia malayi Serotonin receptor 0.0017 0 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0 0.5
Brugia malayi hypothetical protein 0.0017 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0 0.5
Schistosoma mansoni amine GPCR 0.0017 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Brugia malayi sulfakinin receptor protein 0.0017 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0 0.5
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0223 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0 0.5
Brugia malayi follicle stimulating hormone receptor 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0 0.5
Echinococcus granulosus neuropeptide s receptor 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0 0.5
Schistosoma mansoni opsin-like receptor 0.0017 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0017 0 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0 0.5
Brugia malayi hypothetical protein 0.0017 0 0.5
Brugia malayi Dopamine receptor protein 2 0.0017 0 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0 0.5
Brugia malayi AKH receptor 0.0017 0 0.5
Echinococcus granulosus g-protein coupled receptor 0.0017 0 0.5
Brugia malayi putative neuropeptide receptor 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0017 0 0.5
Schistosoma mansoni hypothetical protein 0.0017 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0 0.5
Echinococcus granulosus sex peptide receptor 0.0017 0 0.5
Brugia malayi hypothetical protein 0.0017 0 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0017 0 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0 0.5
Schistosoma mansoni adenoreceptor 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0 0.5
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0223 1 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0 0.5
Schistosoma mansoni amine GPCR 0.0017 0 0.5
Schistosoma mansoni histamine h1 receptor 0.0017 0 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0017 0 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0 0.5
Schistosoma mansoni opsin-like receptor 0.0017 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0 0.5
Echinococcus granulosus hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0017 0 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0017 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0 0.5
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0223 1 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Brugia malayi Melatonin receptor type 1A 0.0017 0 0.5
Echinococcus granulosus fmrfamide receptor 0.0017 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0 0.5
Brugia malayi G-protein coupled receptor 0.0017 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0 0.5
Brugia malayi Serotonin receptor 0.0017 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0 0.5
Brugia malayi larval opioid receptor 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0017 0 0.5
Echinococcus multilocularis somatostatin receptor 0.0017 0 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Plasmodium falciparum enoyl-acyl carrier reductase 0.0223 1 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0 0.5
Echinococcus multilocularis allatostatin A receptor 0.0017 0 0.5
Schistosoma mansoni amine GPCR 0.0017 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0017 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0 0.5
Brugia malayi G protein-coupled receptor 0.0017 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0 0.5
Brugia malayi hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus multilocularis serotonin receptor 0.0017 0 0.5
Brugia malayi hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Schistosoma mansoni hypothetical protein 0.0017 0 0.5
Brugia malayi ORL1-like opioid receptor 0.0017 0 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0 0.5
Brugia malayi RE15519p 0.0017 0 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0 0.5
Echinococcus multilocularis serotonin receptor 0.0017 0 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus multilocularis sex peptide receptor 0.0017 0 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0017 0 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0017 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0017 0 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Trichomonas vaginalis hypothetical protein 0.0223 1 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0 0.5
Brugia malayi neuropeptide F receptor 0.0017 0 0.5
Brugia malayi hypothetical protein 0.0017 0 0.5
Brugia malayi hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0 0.5
Schistosoma mansoni amine GPCR 0.0017 0 0.5
Brugia malayi G-protein coupled receptor 0.0017 0 0.5
Brugia malayi GnHR receptor homolog 0.0017 0 0.5
Echinococcus granulosus orexin receptor type 2 0.0017 0 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0 0.5
Brugia malayi neuropeptide F receptor 0.0017 0 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0017 0 0.5
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0223 1 0.5
Brugia malayi Dopamine receptor 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0 0.5
Brugia malayi hypothetical protein 0.0017 0 0.5
Schistosoma mansoni myosin xvIII 0.0017 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0017 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0017 0 0.5
Echinococcus granulosus somatostatin receptor 0.0017 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0 0.5
Brugia malayi hypothetical protein 0.0017 0 0.5
Onchocerca volvulus 0.0017 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.004 uM Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluorimetric analysis ChEMBL. 24450589
MIC90 (functional) = 0.5 uM Antitubercular activity against wild type Mycobacterium tuberculosis H37Rv ATCC 25618 assessed as growth inhibition after 6 days by resazurin dye-based assay ChEMBL. 24450589

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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