Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0095 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.3724 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.0095 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.3724 | 0.3724 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3724 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3724 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.028 | 1 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0095 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3724 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0095 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3724 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.3724 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0095 | 0 | 0.5 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0095 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.3724 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3724 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.0095 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin I | 0.0095 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.3724 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0095 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3724 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3724 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3724 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.18 uM | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | ChEMBL. | 24594525 |
IC50 (binding) | = 14.3 uM | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | ChEMBL. | 24594525 |
Inhibition (binding) | = 19 % | Inhibition of amyloid beta (1 to 42) aggregation (unknown origin) at 50 uM after 1 hr by thioflavin T fluorescence assay relative to control | ChEMBL. | 24594525 |
Inhibition (binding) | = 25 % | Inhibition of amyloid beta (1 to 42) aggregation (unknown origin) at 100 uM after 1 hr by thioflavin T fluorescence assay relative to control | ChEMBL. | 24594525 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.