TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 519.143 | Formula: C20H13Br2N3O4
H donors: 2 H acceptors: 5 LogP: 5.2 Rotable bonds: 4
Rule of 5 violations (Lipinski): 2
SMILES: Brc1ccc(c(c1)Cn1c(nc2c1cc(cc2)[N+](=O)[O-])c1cc(Br)ccc1O)O
InChi: 1S/C20H13Br2N3O4/c21-12-1-5-18(26)11(7-12)10-24-17-9-14(25(28)29)3-4-16(17)23-20(24)15-8-13(22)2-6-19(15)27/h1-9,26-27H,10H2
InChiKey: FAYVDJDMYLGDEB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	pitrilysin metallopeptidase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Metalloprotease, insulinase family	Get druggable targets OG5_127676	All targets in OG5_127676
Plasmodium falciparum	falcilysin	Get druggable targets OG5_127676	All targets in OG5_127676
Trypanosoma congolense	pitrilysin-like metalloprotease, putative	Get druggable targets OG5_127676	All targets in OG5_127676
Babesia bovis	peptidase M16 inactive domain containing protein	Get druggable targets OG5_127676	All targets in OG5_127676
Schistosoma japonicum	ko:K06972 pitrilysin metalloproteinase 1, putative	Get druggable targets OG5_127676	All targets in OG5_127676
Plasmodium yoelii	falcilysin-related	Get druggable targets OG5_127676	All targets in OG5_127676
Trypanosoma cruzi	pitrilysin-like metalloprotease, putative	Get druggable targets OG5_127676	All targets in OG5_127676
Treponema pallidum	hypothetical protein	Get druggable targets OG5_127676	All targets in OG5_127676
Leishmania donovani	pitrilysin-like metalloprotease	Get druggable targets OG5_127676	All targets in OG5_127676
Trichomonas vaginalis	Clan ME, family M16, insulinase-like metallopeptidase	Get druggable targets OG5_127676	All targets in OG5_127676
Leishmania mexicana	pitrilysin-like metalloprotease,metallo-peptidase, Clan ME, Family M16C	Get druggable targets OG5_127676	All targets in OG5_127676
Trichomonas vaginalis	Clan ME, family M16, insulinase-like metallopeptidase	Get druggable targets OG5_127676	All targets in OG5_127676
Schistosoma mansoni	eupitrilysin (M16 family)	Get druggable targets OG5_127676	All targets in OG5_127676
Schistosoma japonicum	ko:K06972 Pitrilysin metalloproteinase 1, putative	Get druggable targets OG5_127676	All targets in OG5_127676
Trichomonas vaginalis	Clan ME, family M16, insulinase-like metallopeptidase	Get druggable targets OG5_127676	All targets in OG5_127676
Entamoeba histolytica	Zn-dependent peptidase, putative	Get druggable targets OG5_127676	All targets in OG5_127676
Trypanosoma brucei	pitrilysin-like metalloprotease	Get druggable targets OG5_127676	All targets in OG5_127676
Plasmodium knowlesi	falcilysin, putative	Get druggable targets OG5_127676	All targets in OG5_127676
Plasmodium berghei	bergheilysin	Get druggable targets OG5_127676	All targets in OG5_127676
Echinococcus multilocularis	presequence protease, mitochondrial	Get druggable targets OG5_127676	All targets in OG5_127676
Toxoplasma gondii	peptidase M16 inactive domain-containing protein	Get druggable targets OG5_127676	All targets in OG5_127676
Plasmodium vivax	falcilysin, putative	Get druggable targets OG5_127676	All targets in OG5_127676
Theileria parva	falcilysin, putative	Get druggable targets OG5_127676	All targets in OG5_127676
Leishmania major	pitrilysin-like metalloprotease,metallo-peptidase, Clan ME, Family M16C	Get druggable targets OG5_127676	All targets in OG5_127676
Candida albicans	potential metalloendopeptidase similar to S. cerevisiae CYM1	Get druggable targets OG5_127676	All targets in OG5_127676
Leishmania infantum	pitrilysin-like metalloprotease,metallo-peptidase, Clan ME, Family M16C	Get druggable targets OG5_127676	All targets in OG5_127676
Echinococcus granulosus	presequence protease mitochondrial	Get druggable targets OG5_127676	All targets in OG5_127676
Schistosoma japonicum	Presequence protease, mitochondrial precursor, putative	Get druggable targets OG5_127676	All targets in OG5_127676
Giardia lamblia	Metalloprotease, insulinase family	Get druggable targets OG5_127676	All targets in OG5_127676
Trypanosoma brucei gambiense	pitrilysin-like metalloprotease, putative,metallo-peptidase, Clan ME, Family M16C, putative	Get druggable targets OG5_127676	All targets in OG5_127676
Theileria parva	falcilysin, putative	Get druggable targets OG5_127676	All targets in OG5_127676
Chlamydia trachomatis	zinc metalloprotease	Get druggable targets OG5_127676	All targets in OG5_127676
Trichomonas vaginalis	Clan ME, family M16, insulinase-like metallopeptidase	Get druggable targets OG5_127676	All targets in OG5_127676
Leishmania braziliensis	pitrilysin-like metalloprotease,metallo-peptidase, Clan ME, Family M16C	Get druggable targets OG5_127676	All targets in OG5_127676
Neospora caninum	Mitochondrial presequence protease (EC 3.4.24.-) (Precursor), related	Get druggable targets OG5_127676	All targets in OG5_127676

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0319	0.1206	0.5745
Schistosoma mansoni	protein tyrosine phosphatase	0.018	0.0641	0.2836
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.018	0.0641	0.2847
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.018	0.0641	0.2836
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0522	0.2031	1
Echinococcus granulosus	nephrin	0.0139	0.0472	0.1975
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0319	0.1206	0.5751
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Onchocerca volvulus		0.018	0.0641	0.0193
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Onchocerca volvulus		0.018	0.0641	0.0193
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0522	0.2031	0.174
Schistosoma mansoni	cell adhesion molecule	0.0139	0.0472	0.1964
Echinococcus granulosus	roundabout 2	0.0139	0.0472	0.1975
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Schistosoma mansoni	titin	0.0139	0.0472	0.1964
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Trypanosoma brucei	protein tyrosine phosphatase 1	0.018	0.0641	1
Brugia malayi	Protein-tyrosine phosphatase 1	0.018	0.0641	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0139	0.0472	0.6923
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.018	0.0641	1
Schistosoma mansoni	hemicentin	0.0139	0.0472	0.1964
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.018	0.0641	0.2847
Echinococcus multilocularis	titin	0.0139	0.0472	0.1975
Echinococcus granulosus	anosmin 1	0.0139	0.0472	0.1975
Schistosoma mansoni	factor for adipocyte differentiation	0.0139	0.0472	0.1964
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0139	0.0472	0.6923
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0319	0.1206	0.5745
Onchocerca volvulus		0.018	0.0641	0.0193
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0139	0.0472	0.1975
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.018	0.0641	0.2836
Schistosoma mansoni	cell adhesion molecule	0.0139	0.0472	0.1964
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.018	0.0641	0.2847
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0319	0.1206	0.5745
Trichomonas vaginalis	Clan ME, family M16, insulinase-like metallopeptidase	0.0045	0.0091	0.1418
Echinococcus granulosus	titin	0.0139	0.0472	0.1975
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.018	0.0641	0.2847
Echinococcus granulosus	anosmin 1	0.0139	0.0472	0.1975
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0319	0.1206	0.5751
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0139	0.0472	0.1975
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Echinococcus multilocularis		0.018	0.0641	0.2847
Onchocerca volvulus	4.1 G protein, putative homolog	0.018	0.0641	0.0193
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0319	0.1206	0.5751
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.018	0.0641	0.2847
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0319	0.1206	0.5751
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0139	0.0472	0.1975
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.018	0.0641	0.2847
Echinococcus granulosus	Netrin receptor DCC	0.0139	0.0472	0.1975
Echinococcus multilocularis	neuroglian	0.0139	0.0472	0.1975
Echinococcus multilocularis	hypothetical protein	0.018	0.0641	0.2847
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.018	0.0641	0.2847
Schistosoma mansoni	pcd6 interacting protein-related	0.018	0.0641	0.2836
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.018	0.0641	0.2847
Onchocerca volvulus		0.018	0.0641	0.0193
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.018	0.0641	0.2847
Echinococcus granulosus	roundabout 2	0.0139	0.0472	0.1975
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.018	0.0641	0.2847
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0139	0.0472	0.1975
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0139	0.0472	0.1975
Schistosoma mansoni	serine/threonine protein kinase	0.0139	0.0472	0.1964
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Schistosoma mansoni	titin	0.0139	0.0472	0.1964
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0139	0.0472	0.1975
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Echinococcus granulosus	titin	0.0139	0.0472	0.1975
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.018	0.0641	0.2836
Loa Loa (eye worm)	hypothetical protein	0.2163	0.8702	0.9181
Onchocerca volvulus		0.018	0.0641	0.0193
Leishmania major	tyrosine specific protein phosphatase, putative	0.018	0.0641	1
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.018	0.0641	0.2847
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Onchocerca volvulus		0.018	0.0641	0.0193
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0319	0.1206	0.5751
Schistosoma mansoni	titin	0.0139	0.0472	0.1964
Schistosoma mansoni	protein tyrosine phosphatase	0.0319	0.1206	0.5745
Onchocerca volvulus		0.018	0.0641	0.0193
Onchocerca volvulus		0.018	0.0641	0.0193
Onchocerca volvulus		0.2302	0.9266	1
Onchocerca volvulus		0.018	0.0641	0.0193
Onchocerca volvulus		0.018	0.0641	0.0193
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.018	0.0641	0.2847
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.018	0.0641	0.2847
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0319	0.1206	0.5751
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0139	0.0472	0.6923
Onchocerca volvulus		0.018	0.0641	0.0193
Plasmodium vivax	falcilysin, putative	0.0045	0.0091	0.5
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.018	0.0641	1
Loa Loa (eye worm)	protein tyrosine phosphatase	0.018	0.0641	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0522	0.2031	0.1637
Treponema pallidum	hypothetical protein	0.0045	0.0091	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.018	0.0641	0.2836
Onchocerca volvulus		0.018	0.0641	0.0193
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.018	0.0641	0.2847
Trypanosoma cruzi	hypothetical protein, conserved	0.0139	0.0472	0.6923
Trichomonas vaginalis	pten, drome, putative	0.018	0.0641	1
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.018	0.0641	1
Echinococcus granulosus	Fibronectin type III	0.0139	0.0472	0.1975
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0522	0.2031	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Echinococcus multilocularis	roundabout 2	0.0139	0.0472	0.1975
Schistosoma mansoni	tripartite motif protein trim9	0.0139	0.0472	0.1964
Toxoplasma gondii	peptidase M16 inactive domain-containing protein	0.0044	0.0088	0.5
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0139	0.0472	0.1975
Echinococcus multilocularis	anosmin 1	0.0139	0.0472	0.1975
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.018	0.0641	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.018	0.0641	0.2847
Schistosoma mansoni	cell adhesion molecule	0.0139	0.0472	0.1964
Onchocerca volvulus		0.018	0.0641	0.0193
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0319	0.1206	0.5751
Trichomonas vaginalis	Clan ME, family M16, insulinase-like metallopeptidase	0.0045	0.0091	0.1418
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.018	0.0641	0.2847
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.018	0.0641	0.0189
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.018	0.0641	0.2847
Echinococcus multilocularis	cell adhesion molecule	0.0139	0.0472	0.1975
Echinococcus granulosus	anosmin 1	0.0139	0.0472	0.1975
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.018	0.0641	1
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0319	0.1206	0.5751
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0522	0.2031	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Echinococcus multilocularis	roundabout 2	0.0139	0.0472	0.1975
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0319	0.1206	0.5745
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.018	0.0641	0.2847
Echinococcus granulosus	G1Y162 protein	0.0139	0.0472	0.1975
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Schistosoma mansoni	nephrin	0.0139	0.0472	0.1964
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0139	0.0472	0.1975
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Onchocerca volvulus		0.018	0.0641	0.0193
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Brugia malayi	hypothetical protein	0.018	0.0641	0.0178
Trichomonas vaginalis	Clan ME, family M16, insulinase-like metallopeptidase	0.0045	0.0091	0.1418
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Echinococcus granulosus	EG95	0.0139	0.0472	0.1975
Echinococcus multilocularis	Fibronectin, type III	0.0139	0.0472	0.1975
Echinococcus multilocularis	usherin	0.0139	0.0472	0.1975
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.018	0.0641	0.2847
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Echinococcus granulosus	Netrin receptor DCC	0.0139	0.0472	0.1975
Echinococcus multilocularis	titin	0.0139	0.0472	0.1975
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.018	0.0641	0.2847
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0319	0.1206	0.0819
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.018	0.0641	0.2836
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0319	0.1206	0.5745
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Brugia malayi	hypothetical protein	0.018	0.0641	0.0178
Echinococcus multilocularis	roundabout 2	0.0139	0.0472	0.1975
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.018	0.0641	0.2847
Brugia malayi	Protein-tyrosine phosphatase	0.018	0.0641	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.018	0.0641	0.2847
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0139	0.0472	0.1975
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.018	0.0641	0.2847
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Giardia lamblia	Protein tyrosine phosphatase	0.018	0.0641	1
Onchocerca volvulus		0.018	0.0641	0.0193
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.018	0.0641	0.2847
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0139	0.0472	0.1975
Schistosoma mansoni	factor for adipocyte differentiation	0.0139	0.0472	0.1964
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0319	0.1206	0.5751
Schistosoma mansoni	hypothetical protein	0.0139	0.0472	0.1964
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.018	0.0641	1
Onchocerca volvulus		0.018	0.0641	0.0193
Echinococcus multilocularis	anosmin 1	0.0139	0.0472	0.1975
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Onchocerca volvulus		0.018	0.0641	0.0193
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Onchocerca volvulus		0.018	0.0641	0.0193
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Schistosoma mansoni	hypothetical protein	0.0139	0.0472	0.1964
Schistosoma mansoni	neuroglian	0.0139	0.0472	0.1964
Schistosoma mansoni	protein tyrosine phosphatase	0.018	0.0641	0.2836
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.018	0.0641	0.2836
Schistosoma mansoni	cell adhesion molecule	0.0139	0.0472	0.1964
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Schistosoma mansoni	factor for adipocyte differentiation	0.0139	0.0472	0.1964
Leishmania major	hypothetical protein, conserved	0.0139	0.0472	0.6923
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.018	0.0641	0.0178
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.018	0.0641	0.2836
Onchocerca volvulus		0.018	0.0641	0.0193
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Echinococcus multilocularis	Netrin receptor DCC	0.0139	0.0472	0.1975
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Brugia malayi	hypothetical protein	0.018	0.0641	0.0178
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Chlamydia trachomatis	zinc metalloprotease	0.0045	0.0091	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Trichomonas vaginalis	Clan ME, family M16, insulinase-like metallopeptidase	0.0045	0.0091	0.1418
Giardia lamblia	Metalloprotease, insulinase family	0.0045	0.0091	0.0127
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.018	0.0641	0.0178
Schistosoma mansoni	myosin-binding protein-related	0.0139	0.0472	0.1964
Brugia malayi	hypothetical protein	0.018	0.0641	0.0178
Echinococcus multilocularis	Netrin receptor DCC	0.0139	0.0472	0.1975
Echinococcus granulosus	roundabout 2	0.0139	0.0472	0.1975
Onchocerca volvulus		0.018	0.0641	0.0193
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.018	0.0641	0.2836
Echinococcus multilocularis	transfer RNA-Phe	0.0139	0.0472	0.1975
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.018	0.0641	0.2847
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Echinococcus granulosus	usherin	0.0139	0.0472	0.1975
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.018	0.0641	0.2847
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.018	0.0641	0.2836
Echinococcus granulosus	neuroglian	0.0139	0.0472	0.1975
Loa Loa (eye worm)	hypothetical protein	0.2163	0.8702	0.9181
Plasmodium falciparum	falcilysin	0.0045	0.0091	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.018	0.0641	0.0189
Echinococcus granulosus	cell adhesion molecule	0.0139	0.0472	0.1975
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Loa Loa (eye worm)	hypothetical protein	0.2163	0.8702	0.9181
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.018	0.0641	0.2847
Loa Loa (eye worm)	hypothetical protein	0.2343	0.9436	1
Onchocerca volvulus		0.018	0.0641	0.0193
Onchocerca volvulus		0.018	0.0641	0.0193
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0139	0.0472	0.1975
Echinococcus multilocularis	anosmin 1	0.0139	0.0472	0.1975
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.018	0.0641	0.0189
Loa Loa (eye worm)	hypothetical protein	0.018	0.0641	0.0189
Schistosoma mansoni	ephrin receptor	0.0139	0.0472	0.1964
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Brugia malayi	hypothetical protein	0.018	0.0641	0.0178
Schistosoma mansoni	nephrin	0.0139	0.0472	0.1964
Onchocerca volvulus		0.018	0.0641	0.0193
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0139	0.0472	0.1975
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.018	0.0641	0.2847
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0319	0.1206	0.5751
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.018	0.0641	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Echinococcus granulosus	protein tyrosine phosphatase n9	0.018	0.0641	0.2847
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.018	0.0641	0.0178
Echinococcus granulosus	contactin	0.0139	0.0472	0.1975
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.018	0.0641	1
Schistosoma mansoni	hypothetical protein	0.0139	0.0472	0.1964
Schistosoma mansoni	cell adhesion molecule	0.0139	0.0472	0.1964

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 42 %	Agonist activity at human PreP assessed as degradation of biotin-labeled amyloid beta (1 to 42) after 2.5 hrs by Immunoblotting assay relative to control	ChEMBL.	24602793
Activity (binding)	= 45 %	Agonist activity at human PreP assessed as degradation of ATP synthase pF1beta subunit (2 to 56) after 2.5 hrs by Immunoblotting assay relative to control	ChEMBL.	24602793
EC50 (binding)	= 0.012 uM	Agonist activity at human PreP assessed as degradation of ATP synthase pF1beta subunit (2 to 56) after 2.5 hrs by Immunoblotting assay	ChEMBL.	24602793
EC50 (binding)	= 0.152 uM	Agonist activity at human PreP assessed as degradation of fluorogenic substrate V measured for 10 mins by fluorometric analysis	ChEMBL.	24602793
EC50 (binding)	= 0.713 uM	Agonist activity at human PreP assessed as degradation of biotin-labeled amyloid beta (1 to 42) after 2.5 hrs by Immunoblotting assay	ChEMBL.	24602793

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3127264

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1829871