Detailed information for compound 182993

Basic information

Technical information
  • TDR Targets ID: 182993
  • Name: (2R)-2-amino-3-selanylpropanoic acid
  • MW: 168.053 | Formula: C3H7NO2Se
  • H donors: 2 H acceptors: 2 LogP: -3.12 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H](C(=O)O)C[SeH]
  • InChi: 1S/C3H7NO2Se/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1
  • InChiKey: ZKZBPNGNEQAJSX-REOHCLBHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R)-2-amino-3-selanyl-propanoic acid
  • (2R)-2-amino-3-selenylpropanoic acid
  • (2R)-2-azanyl-3-selanyl-propanoic acid
  • (2R)-2-amino-3-hydroseleno-propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Echinococcus granulosus lamin 0.0028 0.002 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0024 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0006 0.0006
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0009 0.0007
Toxoplasma gondii isocitrate dehydrogenase 0.1146 0.1445 0.172
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0043 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0024 0.0018
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0009 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0014 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Brugia malayi Dihydrofolate reductase 0.786 1 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.002 0.002
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0014 0.037
Schistosoma mansoni pyruvate kinase 0.0033 0.0027 0.0021
Echinococcus granulosus importin subunit beta 1 0.0029 0.0021 0.002
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0006 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0114 0.011
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0009 0.0011
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0006 0.0008
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0009 0.0044
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.1146 0.1445 0.1438
Echinococcus granulosus pyruvate kinase 0.0033 0.0027 0.0025
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0027 0.0022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0018 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0024 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0012 0.0004
Schistosoma mansoni ran 0.0021 0.0012 0.0005
Brugia malayi Smad1 0.0017 0.0006 0.0003
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.6608 0.8405 1
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.2488 0.3155 0.315
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0139 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0014
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0018 0.0012
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0024 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Echinococcus granulosus Smad4 0.0017 0.0006 0.0005
Brugia malayi Pre-SET motif family protein 0.0215 0.0259 0.0255
Brugia malayi Pre-SET motif family protein 0.0031 0.0024 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0009 0.0006
Giardia lamblia Pyruvate kinase 0.0033 0.0027 1
Plasmodium falciparum pyruvate kinase 0.0033 0.0027 0.0025
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.786 1 1
Brugia malayi hypothetical protein 0.0037 0.0032 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0043 0.0041
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0002
Brugia malayi thymidylate synthase 0.2488 0.3155 0.3152
Schistosoma mansoni lamin 0.0028 0.002 0.0014
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0027 0.0019
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0012 0.0004
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 0.2525
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0012 0.0014
Echinococcus multilocularis GPCR, family 2 0.0032 0.0025 0.0024
Entamoeba histolytica hypothetical protein 0.0037 0.0032 0.1525
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0025 0.0024
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0014 0.0096
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0014 0.0014
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.6608 0.8405 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0014 0.0006
Mycobacterium tuberculosis Hypothetical protein 0.1184 0.1493 0.1485
Schistosoma mansoni hypothetical protein 0.0069 0.0073 0.0067
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.6608 0.8405 1
Echinococcus granulosus dihydrofolate reductase 0.786 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0139 0.0162 0.0162
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0006 0.0005
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0259 0.0259
Leishmania major pyruvate kinase 0.0033 0.0027 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0043 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.002
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0027 0.0181
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0027 0.0032
Loa Loa (eye worm) dihydrofolate reductase 0.786 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0043 0.0041
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0014 0.0007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0008 0.0008
Echinococcus multilocularis pyruvate kinase 0.0026 0.0018 0.0016
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0009 0.0044
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0009 0.0001
Brugia malayi MH2 domain containing protein 0.0017 0.0006 0.0003
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0027 0.0022
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0114 0.0114
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1146 0.1445 0.1711
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.1146 0.1445 0.1444
Entamoeba histolytica hypothetical protein 0.0037 0.0032 0.1525
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0027 0.0027
Onchocerca volvulus 0.2488 0.3155 1
Brugia malayi MH1 domain containing protein 0.0017 0.0006 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.0304 0.0304
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1146 0.1445 0.1711
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0018 0.0017
Leishmania major dihydrofolate reductase-thymidylate synthase 0.6608 0.8405 1
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0019
Leishmania major pyruvate kinase 0.0033 0.0027 0.0022
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0006 0.0006
Entamoeba histolytica tartrate dehydrogenase, putative 0.0139 0.0162 1
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0019
Echinococcus multilocularis snurportin 1 0.0308 0.0377 0.0375
Entamoeba histolytica hypothetical protein 0.0023 0.0014 0.038
Giardia lamblia GTOR 0.0019 0.0009 0.1361
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0139 0.0162 0.0158
Brugia malayi Importin beta-1 subunit 0.0029 0.0021 0.0018
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0139 0.0162 0.0158
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0024 0.0028
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.786 1 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0009 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0024 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0018 0.0123
Echinococcus multilocularis lamin dm0 0.0028 0.002 0.0018
Brugia malayi MH1 domain containing protein 0.0017 0.0006 0.0003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1146 0.1445 0.1444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0027 0.0032
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0021 0.002
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0139 0.0162 0.0135
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0027 0.0022
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.1184 0.1493 0.1768
Echinococcus granulosus snurportin 1 0.0308 0.0377 0.0375
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1146 0.1445 0.172
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0027 0.0023
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0009 0.0001
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0009 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.1184 0.1493 1
Echinococcus granulosus thymidylate synthase 0.2488 0.3155 0.3154
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0032 0.0026
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0139 0.0162 0.0158
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0025 0.0025
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0018 0.0022
Plasmodium vivax importin-beta 2, putative 0.0029 0.0021 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0008 0.0057
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0019
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0027 0.0022
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0027 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Echinococcus multilocularis pyruvate kinase 0.0033 0.0027 0.0025
Schistosoma mansoni pyruvate kinase 0.0033 0.0027 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0021 0.0021
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0009 0.0001
Echinococcus multilocularis isocitrate dehydrogenase 0.1146 0.1445 0.1444
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.002 0.002
Leishmania major GTP-binding protein, putative 0.0021 0.0012 0.0004
Entamoeba histolytica Ran family GTPase 0.0021 0.0012 0.02
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0043 0.0041
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0012 0.001
Schistosoma mansoni ran 0.0021 0.0012 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0073 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0025 0.0024
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0139 0.0162 0.0154
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0021 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Loa Loa (eye worm) isocitrate dehydrogenase 0.1146 0.1445 0.1445
Brugia malayi Probable isocitrate dehydrogenase 0.0139 0.0162 0.0158
Echinococcus multilocularis musashi 0.0028 0.002 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0009 0.0011
Brugia malayi MH2 domain containing protein 0.0017 0.0006 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0009 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0009 0.0011
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.6608 0.8405 1
Schistosoma mansoni hypothetical protein 0.0308 0.0377 0.0371
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0027 0.0025
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 0.0006
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0027 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0043 0.0043
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0139 0.0162 0.1085
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.1146 0.1445 0.1711
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0139 0.0162 0.0156
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.1146 0.1445 0.1713
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0008 0.0007
Echinococcus multilocularis pyruvate kinase 0.0017 0.0006 0.0005
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0009 0.0001
Toxoplasma gondii exonuclease III APE 0.0019 0.0008 0.001
Echinococcus multilocularis pyruvate kinase 0.0033 0.0027 0.0025
Brugia malayi Probable isocitrate dehydrogenase 0.0139 0.0162 0.0158
Schistosoma mansoni intermediate filament proteins 0.0028 0.002 0.0014
Echinococcus multilocularis thymidylate synthase 0.2488 0.3155 0.3154
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0018 0.0012
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0009 0.0007
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0139 0.0162 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0139 0.0162 0.016
Schistosoma mansoni isocitrate dehydrogenase 0.0139 0.0162 0.0156
Entamoeba histolytica hypothetical protein 0.0027 0.0018 0.0643
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0009 0.0001
Brugia malayi RNA, U transporter 1 0.0082 0.0089 0.0085
Echinococcus granulosus GPCR family 2 0.0032 0.0025 0.0024
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0008 0.1038
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.2488 0.3155 0.3136
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0006 0.0005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0032 0.003
Schistosoma mansoni lamin 0.0028 0.002 0.0014
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0022 0.0021
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0009 0.0001
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0008 0.0005
Plasmodium falciparum importin beta, putative 0.0029 0.0021 0.0018
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0012 0.001
Trichomonas vaginalis set domain proteins, putative 0.0245 0.0296 0.1985
Echinococcus multilocularis smad 0.0017 0.0006 0.0005
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.1146 0.1445 0.1444
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0024
Echinococcus granulosus intermediate filament protein 0.0028 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0014
Loa Loa (eye worm) Smad1 0.0017 0.0006 0.0006
Echinococcus granulosus pyruvate kinase 0.0033 0.0027 0.0025
Brugia malayi isocitrate dehydrogenase 0.1146 0.1445 0.1442
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0009 0.0011
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.1146 0.1445 0.144
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0008 0.001
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0069 0.0073 0.0073
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0018 0.0022
Echinococcus multilocularis Smad4 0.0017 0.0006 0.0005
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0027 0.0181
Leishmania major importin beta-1 subunit, putative 0.0023 0.0014 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0009 0.0007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0025 0.0024
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.2488 0.3155 0.3149
Echinococcus granulosus pyruvate kinase 0.0017 0.0006 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0027 0.0027
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0009 0.0011
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0008 0.5
Schistosoma mansoni dihydrofolate reductase 0.786 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.0304 0.0304
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0006 0.0005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0025 0.0024
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0027 0.0032
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0002
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.0377 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0012 0.0014
Echinococcus granulosus pyruvate kinase 0.0017 0.0006 0.0005
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.6608 0.8405 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0027 0.0027
Trichomonas vaginalis ran, putative 0.0021 0.0012 0.0077
Brugia malayi hypothetical protein 0.1184 0.1493 0.149
Schistosoma mansoni unc-13 (munc13) 0.0139 0.0162 0.0156
Onchocerca volvulus 0.0031 0.0024 0.0012
Loa Loa (eye worm) hypothetical protein 0.0101 0.0114 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0043 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.002 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Entamoeba histolytica hypothetical protein 0.0037 0.0032 0.1525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0139 0.0162 0.016
Brugia malayi intermediate filament protein 0.0028 0.002 0.0016
Entamoeba histolytica hypothetical protein 0.0037 0.0032 0.1525
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0008 0.0057
Schistosoma mansoni hypothetical protein 0.0037 0.0032 0.0026
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0021 0.0025
Onchocerca volvulus 0.0245 0.0296 0.0882
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0008 0.0007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1146 0.1445 0.1444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0009 0.0001
Schistosoma mansoni pyruvate kinase 0.0017 0.0006 0.0000027523
Leishmania major isocitrate dehydrogenase, putative 0.0139 0.0162 0.0183
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0024 0.0022
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0018 0.0017
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.786 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0139 0.0162 1
Echinococcus granulosus lamin dm0 0.0028 0.002 0.0018
Echinococcus multilocularis pyruvate kinase 0.0017 0.0006 0.0005
Mycobacterium ulcerans thymidylate synthase 0.2488 0.3155 0.3149
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0139 0.0162 0.016
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0021 0.0025
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1146 0.1445 0.1444
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 0.0008
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.1146 0.1445 0.1713
Echinococcus multilocularis pyruvate kinase 0.0017 0.0006 0.0005
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0009 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0043 0.0041
Chlamydia trachomatis dihydrofolate reductase 0.786 1 1
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0139 0.0162 0.016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0032 0.003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0008 0.0003
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0009 0.0003
Echinococcus multilocularis lamin 0.0028 0.002 0.0018
Brugia malayi MH2 domain containing protein 0.0251 0.0304 0.0301
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0009 0.0003
Echinococcus granulosus smad 0.0017 0.0006 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0114 0.011
Schistosoma mansoni importin beta-1 0.0029 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Toxoplasma gondii isocitrate dehydrogenase 0.1146 0.1445 0.172
Loa Loa (eye worm) thymidylate synthase 0.2488 0.3155 0.3155
Brugia malayi Isocitrate dehydrogenase 0.1146 0.1445 0.1442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0043 0.0037
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0025 0.0022
Trypanosoma brucei isocitrate dehydrogenase, putative 0.1146 0.1445 0.172
Echinococcus granulosus pyruvate kinase 0.0017 0.0006 0.0005
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0027 0.0023
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0014 0.0096
Echinococcus multilocularis dihydrofolate reductase 0.786 1 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0025 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0012 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0009 0.0006
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0009 0.0001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0008 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0009 0.0061
Plasmodium vivax SET domain protein, putative 0.0031 0.0024 0.0021

Activities

Activity type Activity value Assay description Source Reference
Fold induction (binding) = 1 Glutathione peroxidase activity of the compound was determined in V79 cells at 30 microM expressed as fold induction of GPx activity to control value ChEMBL. 12852761
Fold induction (binding) = 4.2 Glutathione peroxidase activity of the compound was determined in V79 cells at 30 microM expressed as fold induction of GPx activity to control value ChEMBL. 12852761
IC50 (functional) = 34 uM Cytotoxicity activity of the compound against V79 cells ChEMBL. 12852761
IC50 (functional) = 39 uM Cytotoxicity activity of the compound against V79 cells ChEMBL. 12852761

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.