Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 1 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0653 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0653 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1106 | 0.1106 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0093 | 0.1106 | 0.1106 |
Trypanosoma brucei | protein kinase, putative | 0.0653 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0653 | 1 | 0.5 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0363 | 0.5395 | 0.5395 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0653 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.0363 | 0.5395 | 0.5395 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0363 | 0.5395 | 0.5395 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0363 | 0.5395 | 0.5395 |
Echinococcus multilocularis | solute carrier family 5 | 0.0363 | 0.5395 | 0.5395 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0653 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0653 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0653 | 1 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.0093 | 0.1106 | 0.1106 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0653 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0653 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0653 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0653 | 1 | 1 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0093 | 0.1106 | 0.1106 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0093 | 0.1106 | 0.1106 |
Echinococcus granulosus | solute carrier family 5 | 0.0363 | 0.5395 | 0.5395 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0093 | 0.1106 | 0.1106 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0653 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0653 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0653 | 1 | 1 |
Brugia malayi | GH02984p | 0.0093 | 0.1106 | 0.1106 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0653 | 1 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.0093 | 0.1106 | 0.1106 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0363 | 0.5395 | 0.5395 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0653 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.0363 | 0.5395 | 0.5395 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0093 | 0.1106 | 1 | |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0653 | 1 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0093 | 0.1106 | 0.1106 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0653 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0653 | 1 | 1 |
Schistosoma mansoni | high-affinity choline transporter | 0.0093 | 0.1106 | 0.1106 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1106 | 0.1106 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0363 | 0.5395 | 0.5395 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 185.8 nM | Inhibition of SGLT2 (unknown origin) expressed in HEK293 cells using 2-NBDG as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by nonradioactive fluorescence glucose uptake assay | ChEMBL. | 24556379 |
IC50 (binding) | = 621 nM | Inhibition of SGLT1 (unknown origin) expressed in HEK293 cells using 2-NBDG as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by nonradioactive fluorescence glucose uptake assay | ChEMBL. | 24556379 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.