Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 1 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0179 | 0.2551 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0116 | 0 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.0363 | 1 | 1 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Schistosoma mansoni | inositol transporter | 0.0363 | 1 | 1 |
Brugia malayi | RE15519p | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Brugia malayi | sulfakinin receptor protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0116 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0116 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0179 | 0.2551 | 0.5 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0363 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0363 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0116 | 0 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0179 | 0.2551 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0116 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0116 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0179 | 0.2551 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0116 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0116 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0179 | 0.2551 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Brugia malayi | G protein-coupled receptor | 0.0116 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0179 | 0.2551 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Echinococcus granulosus | solute carrier family 5 | 0.0363 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0363 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor | 0.0116 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0179 | 0.2551 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0116 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0116 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0179 | 0.2551 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0363 | 1 | 1 |
Brugia malayi | G-protein coupled receptor | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0116 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 5 | 0.0363 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0179 | 0.2551 | 0.5 |
Brugia malayi | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0116 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0116 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 163.2 nM | Inhibition of SGLT2 (unknown origin) expressed in HEK293 cells using 2-NBDG as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by nonradioactive fluorescence glucose uptake assay | ChEMBL. | 24556379 |
IC50 (binding) | = 467.4 nM | Inhibition of SGLT1 (unknown origin) expressed in HEK293 cells using 2-NBDG as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by nonradioactive fluorescence glucose uptake assay | ChEMBL. | 24556379 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.