Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, gamma | 340 aa | 338 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0507 | 0.1003 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0802 | 0.8997 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0507 | 0.1003 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0802 | 0.8997 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.047 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 7 nM | Transcriptional activation of Retinoid X receptor RXR gamma | ChEMBL. | 8765503 |
EC50 (binding) | = 7 nM | Transcriptional activation of Retinoid X receptor RXR gamma | ChEMBL. | 8765503 |
EC50 (binding) | = 8 nM | Transcriptional ativation of Retinoid X receptor RXR alpha | ChEMBL. | 8765503 |
EC50 (binding) | = 8 nM | Transcriptional ativation of Retinoid X receptor RXR alpha | ChEMBL. | 8765503 |
EC50 (binding) | = 9 nM | Transcriptional activation of Retinoid X receptor RXR beta | ChEMBL. | 8765503 |
EC50 (binding) | = 9 nM | Transcriptional activation of Retinoid X receptor RXR beta | ChEMBL. | 8765503 |
EC50 (binding) | = 14 nM | Transcriptional activation of Retinoic acid receptor RAR alpha | ChEMBL. | 8765503 |
EC50 (binding) | = 14 nM | Transcriptional activation of Retinoic acid receptor RAR alpha | ChEMBL. | 8765503 |
EC50 (binding) | = 31 nM | Transcriptional activation of Retinoic acid receptor RAR beta | ChEMBL. | 8765503 |
EC50 (binding) | = 31 nM | Transcriptional activation of Retinoic acid receptor RAR beta | ChEMBL. | 8765503 |
EC50 (binding) | = 121 nM | Transcriptional activation of Retinoic acid receptor RAR gamma | ChEMBL. | 8765503 |
EC50 (binding) | = 121 nM | Transcriptional activation of Retinoic acid receptor RAR gamma | ChEMBL. | 8765503 |
Ki (binding) | = 4 nM | Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR alpha | ChEMBL. | 8765503 |
Ki (binding) | = 4 nM | Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR alpha | ChEMBL. | 8765503 |
Ki (binding) | = 12 nM | Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR beta | ChEMBL. | 8765503 |
Ki (binding) | = 12 nM | Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR beta | ChEMBL. | 8765503 |
Ki (binding) | = 17 nM | Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR gamma | ChEMBL. | 8765503 |
Ki (binding) | = 17 nM | Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR gamma | ChEMBL. | 8765503 |
Ki (binding) | = 2582 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR alpha | ChEMBL. | 8765503 |
Ki (binding) | = 2582 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR alpha | ChEMBL. | 8765503 |
Ki (binding) | = 3115 nM | Inhibition of [3H]-ATRA binfding to Retinoic acid receptor RAR beta | ChEMBL. | 8765503 |
Ki (binding) | = 3115 nM | Inhibition of [3H]-ATRA binfding to Retinoic acid receptor RAR beta | ChEMBL. | 8765503 |
Ki (binding) | = 4206 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma | ChEMBL. | 8765503 |
Ki (binding) | = 4206 nM | Inhibition of [3H]-ATRA binding to Retinoic acid receptor RAR gamma | ChEMBL. | 8765503 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.