TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 912.013 | Formula: C48H58FN7O10
H donors: 4 H acceptors: 6 LogP: 4.2 Rotable bonds: 21
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)Nc1ccc(cc1)[C@H]1CC[C@@H](N1c1ccc(cc1)F)c1ccc(cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@@H]1COCC1)NC(=O)OC)[C@@H]1COCC1
InChi: 1S/C48H58FN7O10/c1-63-47(61)52-41(31-21-25-65-27-31)45(59)54-23-3-5-39(54)43(57)50-34-13-7-29(8-14-34)37-19-20-38(56(37)36-17-11-33(49)12-18-36)30-9-15-35(16-10-30)51-44(58)40-6-4-24-55(40)46(60)42(53-48(62)64-2)32-22-26-66-28-32/h7-18,31-32,37-42H,3-6,19-28H2,1-2H3,(H,50,57)(H,51,58)(H,52,61)(H,53,62)/t31-,32-,37+,38+,39-,40-,41-,42-/m0/s1
InChiKey: DYTBPBHMKPLWRB-VMLBVEHOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Kinase, NEK	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Leishmania major	protein kinase, putative	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Trichomonas vaginalis	TK family protein kinase	0.0325	0.3267	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0325	0.3267	1
Trichomonas vaginalis	STE family protein kinase	0.0325	0.3267	0.5
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Entamoeba histolytica	ankyrin repeat protein	0.0325	0.3267	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0325	0.3267	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0325	0.3267	1
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0325	0.3267	1
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Onchocerca volvulus		0.0325	0.3267	1
Trypanosoma cruzi	protein kinase, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0325	0.3267	1
Schistosoma mansoni	protein kinase	0.0325	0.3267	1
Echinococcus granulosus	epidermal growth factor receptor	0.0325	0.3267	1
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0325	0.3267	0.5
Brugia malayi	SRC-1	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus granulosus	tyrosine kinase	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Echinococcus granulosus	protein tyrosine kinase	0.0325	0.3267	1
Schistosoma mansoni	serine/threonine protein kinase	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0325	0.3267	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0325	0.3267	1
Echinococcus granulosus	epidermal growth factor receptor	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Echinococcus granulosus	integrin linked protein kinase	0.0325	0.3267	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0325	0.3267	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	hypothetical protein	0.0325	0.3267	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0325	0.3267	0.3267
Schistosoma mansoni	hypothetical protein	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0325	0.3267	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	protein kinase	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Schistosoma mansoni	protein kinase	0.0325	0.3267	1
Brugia malayi	Guanylyl cyclase protein 23	0.0325	0.3267	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0325	0.3267	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0325	0.3267	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0325	0.3267	0.3267
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0325	0.3267	0.3267
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0325	0.3267	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK protein kinase	0.0325	0.3267	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0325	0.3267	1
Schistosoma mansoni	ephrin receptor	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0325	0.3267	1
Loa Loa (eye worm)	TK protein kinase	0.0325	0.3267	1
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0325	0.3267	0.5
Giardia lamblia	Protein 21.1	0.0325	0.3267	0.5
Schistosoma mansoni	protein kinase	0.0325	0.3267	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0325	0.3267	0.3267
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0325	0.3267	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Onchocerca volvulus		0.0325	0.3267	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0325	0.3267	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0325	0.3267	0.3267
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Echinococcus multilocularis	heat shock protein 70	0.0325	0.3267	0.3267
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0325	0.3267	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0325	0.3267	0.3267
Onchocerca volvulus		0.0325	0.3267	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus granulosus	lysosomal alpha glucosidase	0.0162	0.1235	0.378
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0325	0.3267	1
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Plasmodium vivax	protein kinase, putative	0.0325	0.3267	0.5
Onchocerca volvulus		0.0325	0.3267	1
Onchocerca volvulus		0.0325	0.3267	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0325	0.3267	0.3267
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Leishmania major	protein kinase, putative	0.0325	0.3267	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0325	0.3267	0.3267
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Giardia lamblia	Kinase, NEK	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0325	0.3267	1
Entamoeba histolytica	hypothetical protein	0.0325	0.3267	0.5
Onchocerca volvulus		0.0325	0.3267	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0325	0.3267	0.3267
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Entamoeba histolytica	tyrosin kinase, putative	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Schistosoma mansoni	protein kinase	0.0325	0.3267	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0325	0.3267	0.3267
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0325	0.3267	1
Schistosoma mansoni	protein kinase	0.0325	0.3267	1
Entamoeba histolytica	hypothetical protein	0.0325	0.3267	0.5
Leishmania major	hypothetical protein, conserved	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0325	0.3267	1
Onchocerca volvulus		0.0325	0.3267	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0325	0.3267	1
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0325	0.3267	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0325	0.3267	0.3267
Trichomonas vaginalis	conserved hypothetical protein	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0325	0.3267	0.3267
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0325	0.3267	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0325	0.3267	0.3267
Loa Loa (eye worm)	TK/ACK protein kinase	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Entamoeba histolytica	hypothetical protein	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0325	0.3267	1
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Echinococcus granulosus	tyrosine kinase	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Plasmodium falciparum	protein kinase, putative	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0325	0.3267	1
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	hypothetical protein	0.0325	0.3267	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0325	0.3267	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0325	0.3267	1
Onchocerca volvulus		0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0325	0.3267	0.5
Schistosoma mansoni	protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0325	0.3267	1
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0325	0.3267	0.3267
Echinococcus multilocularis	tyrosine protein kinase shark	0.0325	0.3267	0.3267
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0325	0.3267	1
Schistosoma mansoni	ephrin receptor	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Brugia malayi	integrin-linked kinase	0.0325	0.3267	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0325	0.3267	0.3267
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Brugia malayi	Raf kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK protein kinase	0.0325	0.3267	1
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Schistosoma mansoni	serine/threonine RGC	0.0325	0.3267	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Echinococcus granulosus	activin receptor type	0.0325	0.3267	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0325	0.3267	1
Echinococcus multilocularis	tyrosine kinase	0.0325	0.3267	0.3267
Echinococcus granulosus	tyrosine protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0162	0.1235	0.1235
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0325	0.3267	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0325	0.3267	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	conserved hypothetical protein	0.0325	0.3267	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0325	0.3267	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0325	0.3267	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0325	0.3267	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0325	0.3267	0.3267
Schistosoma mansoni	protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0325	0.3267	0.3267
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0325	0.3267	0.3267
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	protein kinase	0.0325	0.3267	1
Brugia malayi	protein-tyrosine kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0162	0.1235	0.1235
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0325	0.3267	1
Brugia malayi	SH2 domain containing protein	0.0325	0.3267	1
Onchocerca volvulus		0.0325	0.3267	1
Echinococcus granulosus	insulin receptor	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Entamoeba histolytica	receptor protein kinase, putative	0.0325	0.3267	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0325	0.3267	0.3267
Echinococcus multilocularis	activin receptor type	0.0325	0.3267	0.3267
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Entamoeba histolytica	hypothetical protein	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Entamoeba histolytica	hypothetical protein	0.0325	0.3267	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0325	0.3267	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0325	0.3267	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0325	0.3267	0.3267
Schistosoma mansoni	protein kinase	0.0325	0.3267	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0325	0.3267	1
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Trichomonas vaginalis	AGC family protein kinase	0.0325	0.3267	0.5
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0325	0.3267	1
Entamoeba histolytica	tyrosin kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0325	0.3267	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0325	0.3267	1
Schistosoma mansoni	serine/threonine protein kinase	0.0325	0.3267	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK protein kinase	0.0325	0.3267	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0325	0.3267	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0325	0.3267	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0325	0.3267	0.3267
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Schistosoma mansoni	alpha-glucosidase	0.0139	0.0954	0.2921
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0325	0.3267	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0325	0.3267	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0325	0.3267	0.3267
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0325	0.3267	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0325	0.3267	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0325	0.3267	1
Schistosoma mansoni	protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	conserved hypothetical protein	0.0325	0.3267	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0325	0.3267	0.3267
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0325	0.3267	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0325	0.3267	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0325	0.3267	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0325	0.3267	0.3267
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0325	0.3267	1
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0325	0.3267	1
Giardia lamblia	Kinase	0.0325	0.3267	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0325	0.3267	0.3267
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0162	0.1235	0.378
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0325	0.3267	0.3267
Loa Loa (eye worm)	TK/Met protein kinase	0.0325	0.3267	1
Loa Loa (eye worm)	TK protein kinase	0.0325	0.3267	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Echinococcus multilocularis	FL cytokine receptor	0.0325	0.3267	0.3267
Onchocerca volvulus		0.0325	0.3267	1
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0325	0.3267	0.5
Schistosoma mansoni	alpha-glucosidase	0.0139	0.0954	0.2921
Echinococcus granulosus	tyrosine protein kinase Srms	0.0325	0.3267	1
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Onchocerca volvulus		0.0325	0.3267	1
Onchocerca volvulus		0.0325	0.3267	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0325	0.3267	1
Echinococcus multilocularis	protein tyrosine kinase	0.0325	0.3267	0.3267
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0325	0.3267	0.3267
Echinococcus multilocularis	tyrosine kinase	0.0325	0.3267	0.3267
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0325	0.3267	1
Trypanosoma brucei	protein kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	hypothetical protein	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0325	0.3267	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0325	0.3267	0.3267
Onchocerca volvulus		0.0325	0.3267	1
Onchocerca volvulus		0.0094	0.0385	0.1179
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0325	0.3267	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0325	0.3267	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0325	0.3267	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0325	0.3267	1
Entamoeba histolytica	hypothetical protein	0.0325	0.3267	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0325	0.3267	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Echinococcus multilocularis	protein kinase	0.0325	0.3267	0.3267
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Echinococcus multilocularis	insulin receptor	0.0325	0.3267	0.3267
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Echinococcus multilocularis	activated cdc42 kinase 1	0.0325	0.3267	0.3267
Echinococcus multilocularis	tyrosine protein kinase	0.0325	0.3267	0.3267
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0325	0.3267	0.3267
Echinococcus granulosus	tyrosine protein kinase csk	0.0325	0.3267	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0325	0.3267	0.5
Trypanosoma cruzi	protein kinase, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK protein kinase	0.0325	0.3267	1
Toxoplasma gondii	STE kinase	0.0325	0.3267	0.5
Toxoplasma gondii	protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Echinococcus granulosus	protein kinase	0.0325	0.3267	1
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0325	0.3267	1
Brugia malayi	SH2 domain containing protein	0.0325	0.3267	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	hypothetical protein	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0325	0.3267	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0325	0.3267	0.3267
Trichomonas vaginalis	conserved hypothetical protein	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0325	0.3267	1
Schistosoma mansoni	protein tyrosine kinase	0.0325	0.3267	1
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	hypothetical protein	0.0325	0.3267	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0325	0.3267	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0325	0.3267	0.3267
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0325	0.3267	0.3267
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0325	0.3267	0.3267
Plasmodium falciparum	protein kinase, putative	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Brugia malayi	hypothetical protein	0.0325	0.3267	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0325	0.3267	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0325	0.3267	1
Entamoeba histolytica	hypothetical protein, conserved	0.0325	0.3267	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0325	0.3267	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0325	0.3267	0.3267
Loa Loa (eye worm)	TK protein kinase	0.0325	0.3267	1
Entamoeba histolytica	hypothetical protein	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0325	0.3267	0.3267
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0325	0.3267	0.3267
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0325	0.3267	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0325	0.3267	1
Loa Loa (eye worm)	SRC-1	0.0325	0.3267	1
Onchocerca volvulus		0.0325	0.3267	1
Brugia malayi	hypothetical protein	0.0325	0.3267	1
Brugia malayi	ephrin receptor 1 precursor	0.0325	0.3267	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0325	0.3267	0.3267
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0325	0.3267	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0325	0.3267	0.3267
Onchocerca volvulus		0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0325	0.3267	0.3267
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0325	0.3267	0.3267
Entamoeba histolytica	serine/threonine kinase, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0325	0.3267	1
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0325	0.3267	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0325	0.3267	1
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0325	0.3267	0.3267
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Plasmodium falciparum	protein kinase, putative	0.0325	0.3267	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0325	0.3267	0.3267
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0325	0.3267	0.5
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0162	0.1235	0.378
Echinococcus granulosus	tyrosine kinase	0.0325	0.3267	1
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0325	0.3267	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0325	0.3267	1
Brugia malayi	hypothetical protein	0.0325	0.3267	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK protein kinase	0.0325	0.3267	1
Entamoeba histolytica	tyrosine kinase, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0325	0.3267	1
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0325	0.3267	0.5
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0325	0.3267	0.3267
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0325	0.3267	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0325	0.3267	0.3267
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0325	0.3267	0.3267
Echinococcus granulosus	tyrosine protein kinase Blk	0.0325	0.3267	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0325	0.3267	1
Entamoeba histolytica	protein kinase domain containing protein	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Brugia malayi	Protein kinase domain containing protein	0.0325	0.3267	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0325	0.3267	0.5
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Echinococcus multilocularis	c src tyrosine kinase	0.0325	0.3267	0.3267
Entamoeba histolytica	protein kinase, putative	0.0325	0.3267	0.5
Echinococcus multilocularis	protein kinase	0.0325	0.3267	0.3267
Entamoeba histolytica	serine/threonine kinase, putative	0.0325	0.3267	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0325	0.3267	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0325	0.3267	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0325	0.3267	0.3267
Schistosoma mansoni	tyrosine kinase	0.0325	0.3267	1
Loa Loa (eye worm)	TK protein kinase	0.0325	0.3267	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Stabilty (ADMET)	= 47 %	Metabolic stability in human liver microsomes assessed as compound remaining after 30 mins	ChEMBL.	24400777

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3127314

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1830267