Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta Tm (binding) | = 0.13 degrees C | Binding affinity to ATRD8 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | ChEMBL. | 24188023 |
Delta Tm (binding) | = 1.52 degrees C | Binding affinity to ATRD1 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | ChEMBL. | 24188023 |
Delta Tm (binding) | = 2.29 degrees C | Binding affinity to ATRD2 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | ChEMBL. | 24188023 |
Delta Tm (binding) | = 3.46 degrees C | Binding affinity to ATRD3 (unknown origin) assessed as change in melting temperature by thermal stabilization assay | ChEMBL. | 24188023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.