Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | < 20 % | Competitive inhibition of ER-alpha (unknown origin)-GRIP1 interaction expressed in human HepG2 cells assessed as change in reporter gene activity after 40 hrs relative to control | ChEMBL. | 24360824 |
Activity (binding) | < 20 % | Inhibition of ER-alpha (unknown origin) transcriptional activity expressed in ER-negative human SKBR3 cells coexpressing ERE assessed as change in reporter gene activity after 40 hrs in presence of estradiol relative to control | ChEMBL. | 24360824 |
Activity (binding) | < 20 % | Inhibition of ER-alpha (unknown origin) transcriptional activity expressed in ER-negative human SKBR3 cells coexpressing ERE assessed as change in reporter gene activity after 40 hrs relative to control | ChEMBL. | 24360824 |
Activity (binding) | > 50 % | Competitive inhibition of ER-alpha (unknown origin)-GRIP1 interaction expressed in human HepG2 cells assessed as decrease in reporter gene activity at >50 uM after 40 hrs in presence of estradiol relative to control | ChEMBL. | 24360824 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.