TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 644.438 | Formula: C30H27Cl2F4NO6
H donors: 0 H acceptors: 2 LogP: 8.72 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: FC(Oc1ccc(cc1OCC1CC1)C(Cc1c(Cl)cncc1Cl)OC(=O)c1ccc(c(c1)OCC1CC1)OC(F)F)F
InChi: 1S/C30H27Cl2F4NO6/c31-21-12-37-13-22(32)20(21)11-25(18-5-7-23(42-29(33)34)26(9-18)39-14-16-1-2-16)41-28(38)19-6-8-24(43-30(35)36)27(10-19)40-15-17-3-4-17/h5-10,12-13,16-17,25,29-30H,1-4,11,14-15H2
InChiKey: QWJORUKKCABZPO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4C, cAMP-specific		References
Homo sapiens	phosphodiesterase 4B, cAMP-specific		References
Homo sapiens	phosphodiesterase 4A, cAMP-specific		References
Homo sapiens	phosphodiesterase 4D, cAMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0054	0.0245	0.043
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0268	0.2934	1
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Schistosoma mansoni	protein kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0269	0.2951	1
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Entamoeba histolytica	ankyrin repeat protein	0.0268	0.2934	0.9939
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0488	0.5706	1
Echinococcus multilocularis	FL cytokine receptor	0.0268	0.2934	0.2916
Entamoeba histolytica	hypothetical protein	0.0268	0.2934	0.9939
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.1743	0.557
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0488	0.5706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0054	0.0245	0.043
Schistosoma mansoni	serine/threonine protein kinase	0.0268	0.2934	0.5141
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0268	0.2934	0.512
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0203	0.0356
Echinococcus multilocularis	epidermal growth factor receptor	0.0268	0.2934	0.2916
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0269	0.2951	1
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0054	0.0245	0.0389
Echinococcus multilocularis	tyrosine protein kinase csk	0.0268	0.2934	0.2916
Schistosoma mansoni	protein kinase	0.0269	0.2951	0.5172
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Trypanosoma cruzi	protein kinase, putative	0.0268	0.2934	0.9934
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.015	0.0126
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0268	0.2934	0.512
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0268	0.2934	0.5141
Echinococcus multilocularis	protein tyrosine kinase	0.0268	0.2934	0.2916
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0269	0.2951	0.5151
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	hypothetical protein	0.0447	0.518	0.9078
Echinococcus granulosus	epidermal growth factor receptor	0.0268	0.2934	0.512
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Onchocerca volvulus		0.0268	0.2934	0.3005
Entamoeba histolytica	hypothetical protein	0.0268	0.2934	0.9939
Onchocerca volvulus		0.0268	0.2934	0.3005
Plasmodium falciparum	protein kinase, putative	0.0268	0.2934	0.9934
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Brugia malayi	SRC-1	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Echinococcus multilocularis	insulin receptor	0.0268	0.2934	0.2916
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.2934	1
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0054	0.0245	0.0221
Echinococcus multilocularis	activated cdc42 kinase 1	0.0268	0.2934	0.2916
Entamoeba histolytica	hypothetical protein	0.0268	0.2934	0.9939
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0268	0.2934	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.1743	0.557
Brugia malayi	SH2 domain containing protein	0.0268	0.2934	0.5141
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0268	0.2934	0.512
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0268	0.2934	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.1743	0.557
Entamoeba histolytica	protein kinase domain containing protein	0.0269	0.2951	1
Loa Loa (eye worm)	TK protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0268	0.2934	0.2916
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Trichomonas vaginalis	AGC family protein kinase	0.0268	0.2934	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0268	0.2934	0.2916
Schistosoma mansoni	serine/threonine protein kinase	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Loa Loa (eye worm)	TK protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus multilocularis	activin receptor type	0.0269	0.2951	0.2934
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0447	0.518	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0268	0.2934	0.5141
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Schistosoma mansoni	protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0268	0.2934	0.2916
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0054	0.0245	0.043
Entamoeba histolytica	serine/threonine kinase, putative	0.0268	0.2934	0.9939
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0024	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Echinococcus granulosus	natriuretic peptide receptor 1	0.0268	0.2934	0.512
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Schistosoma mansoni	serine/threonine protein kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Echinococcus multilocularis	tyrosine protein kinase shark	0.0268	0.2934	0.2916
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0268	0.2934	0.2916
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0268	0.2934	0.5141
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0268	0.2934	0.2916
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0268	0.2934	0.512
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0268	0.2934	0.2916
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.2934	1
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0447	0.518	0.5168
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus granulosus	tyrosine protein kinase	0.0268	0.2934	0.512
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0268	0.2934	0.512
Loa Loa (eye worm)	TK protein kinase	0.0268	0.2934	0.5141
Brugia malayi	Tyrosine-protein kinase abl-1	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Schistosoma mansoni	serine/threonine protein kinase	0.0488	0.5706	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0268	0.2934	0.512
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Leishmania major	hypothetical protein, conserved	0.0268	0.2934	0.9934
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0268	0.2934	0.2916
Brugia malayi	integrin-linked kinase	0.0268	0.2934	0.5141
Echinococcus granulosus	insulin receptor	0.0268	0.2934	0.512
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0054	0.0245	0.043
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	cysteine surface protein, putative	0.0268	0.2934	0.9939
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0268	0.2934	0.2916
Echinococcus granulosus	tyrosine protein kinase HCK	0.0268	0.2934	0.512
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0268	0.2934	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.1743	0.557
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Echinococcus multilocularis	protein kinase	0.0268	0.2934	0.2916
Echinococcus granulosus	tyrosine protein kinase csk	0.0268	0.2934	0.512
Schistosoma mansoni	protein kinase	0.0268	0.2934	0.5141
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0268	0.2934	0.2916
Brugia malayi	protein-tyrosine kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Schistosoma mansoni	protein kinase	0.0269	0.2951	0.5172
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0054	0.0245	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Entamoeba histolytica	hypothetical protein, conserved	0.0268	0.2934	0.9939
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.015	0.0221
Echinococcus granulosus	protein kinase	0.0268	0.2934	0.512
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0268	0.2934	0.2916
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0264	0.2886	0.9822
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0488	0.5706	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0268	0.2934	0.9934
Entamoeba histolytica	hypothetical protein	0.0268	0.2934	0.9939
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Plasmodium falciparum	protein kinase, putative	0.0269	0.2951	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0268	0.2934	0.512
Loa Loa (eye worm)	TK/CSK protein kinase	0.0268	0.2934	0.5141
Onchocerca volvulus		0.0268	0.2934	0.3005
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0488	0.5706	0.5696
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0268	0.2934	0.2916
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	TK/ABL protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.186	0.6007
Onchocerca volvulus		0.0268	0.2934	0.3005
Entamoeba histolytica	hypothetical protein	0.0268	0.2934	0.9939
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0268	0.2934	0.5141
Onchocerca volvulus		0.0268	0.2934	0.3005
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Toxoplasma gondii	STE kinase	0.0268	0.2934	0.5448
Giardia lamblia	Kinase, NEK	0.0268	0.2934	0.5448
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0268	0.2934	0.2916
Echinococcus granulosus	tyrosine protein kinase csk	0.0268	0.2934	0.512
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Echinococcus granulosus	activated cdc42 kinase 1	0.0268	0.2934	0.512
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0268	0.2934	0.5141
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.2934	1
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0268	0.2934	0.9939
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0268	0.2934	0.2916
Loa Loa (eye worm)	SRC-1	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Onchocerca volvulus		0.0268	0.2934	0.3005
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.186	0.6007
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Echinococcus multilocularis	tyrosine kinase	0.0268	0.2934	0.2916
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0054	0.0245	0.043
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.2934	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0392	0.4496	0.787
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0447	0.518	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0268	0.2934	0.9939
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0268	0.2934	0.512
Loa Loa (eye worm)	TK/EPH protein kinase	0.0268	0.2934	0.5141
Brugia malayi	ephrin receptor 1 precursor	0.0268	0.2934	0.5141
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0447	0.518	0.5168
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0268	0.2934	0.2916
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0268	0.2934	0.2916
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0268	0.2934	0.512
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0268	0.2934	0.2916
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.015	0.0126
Brugia malayi	Protein kinase domain containing protein	0.0488	0.5706	1
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0268	0.2934	0.5141
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0203	0.0356
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0268	0.2934	0.9939
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Trichomonas vaginalis	glucosylceramidase, putative	0.0264	0.2886	0.9822
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0447	0.518	0.9078
Entamoeba histolytica	ankyrin repeat protein	0.0268	0.2934	0.9939
Entamoeba histolytica	tyrosin kinase, putative	0.0268	0.2934	0.9939
Loa Loa (eye worm)	TK/DDR protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0268	0.2934	0.9939
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0392	0.4496	0.7879
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Echinococcus granulosus	tyrosine protein kinase Srms	0.0268	0.2934	0.512
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0268	0.2934	0.5141
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	serine/threonine protein kinase	0.0268	0.2934	0.5141
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0268	0.2934	0.5141
Brugia malayi	hypothetical protein	0.0268	0.2934	0.5141
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0054	0.0245	0.0389
Onchocerca volvulus		0.0268	0.2934	0.3005
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0054	0.0245	0.043
Echinococcus multilocularis	c src tyrosine kinase	0.0268	0.2934	0.2916
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0268	0.2934	0.2916
Echinococcus granulosus	tyrosine kinase	0.0268	0.2934	0.512
Echinococcus granulosus	epidermal growth factor receptor	0.0268	0.2934	0.512
Echinococcus granulosus	integrin linked protein kinase	0.0268	0.2934	0.512
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0268	0.2934	0.512
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0268	0.2934	0.512
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0268	0.2934	0.512
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0054	0.0245	0.0221
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0268	0.2934	0.512
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0054	0.0245	0.043
Plasmodium falciparum	tyrosine kinase-like protein	0.0268	0.2934	0.9934
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0268	0.2934	0.5141
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Onchocerca volvulus		0.0268	0.2934	0.3005
Brugia malayi	hypothetical protein	0.0037	0.0024	0.0043
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0268	0.2934	0.5448
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0264	0.2886	0.5057
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0269	0.2951	1
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Giardia lamblia	Protein 21.1	0.0268	0.2934	0.5448
Entamoeba histolytica	hypothetical protein	0.0268	0.2934	0.9939
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0264	0.2886	0.5057
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Echinococcus multilocularis	tyrosine kinase	0.0268	0.2934	0.2916
Loa Loa (eye worm)	TK protein kinase	0.0268	0.2934	0.5141
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0054	0.0245	0.043
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0054	0.0245	0.0389
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0447	0.518	0.9074
Schistosoma mansoni	ephrin receptor	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0268	0.2934	0.512
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0054	0.0245	0.0221
Echinococcus granulosus	tyrosine protein kinase Blk	0.0268	0.2934	0.512
Schistosoma mansoni	protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Schistosoma mansoni	protein kinase	0.0268	0.2934	0.5141
Schistosoma mansoni	serine/threonine RGC	0.0268	0.2934	0.5141
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0268	0.2934	0.5141
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0268	0.2934	0.2916
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0054	0.0245	0.043
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Onchocerca volvulus	Tyrosine kinase homolog	0.0268	0.2934	0.3005
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0203	0.0356
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0268	0.2934	0.3005
Echinococcus granulosus	activated cdc42 kinase 1	0.0268	0.2934	0.512
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.1743	0.557
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0054	0.0245	0.043
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0392	0.4496	0.7879
Loa Loa (eye worm)	TK protein kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0268	0.2934	0.9939
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.1743	0.557
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus granulosus	activin receptor type	0.0269	0.2951	0.5151
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	TK protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0268	0.2934	0.9939
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0268	0.2934	0.512
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0245	0.043
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Loa Loa (eye worm)	TK protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Onchocerca volvulus		0.0268	0.2934	0.3005
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.2934	1
Schistosoma mansoni	ephrin receptor	0.0268	0.2934	0.5141
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0268	0.2934	0.9934
Entamoeba histolytica	hypothetical protein	0.0268	0.2934	0.9939
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Giardia lamblia	Kinase, NEK	0.0268	0.2934	0.5448
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0268	0.2934	0.512
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0268	0.2934	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	glucosylceramidase, putative	0.0264	0.2886	0.9822
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Onchocerca volvulus		0.0268	0.2934	0.3005
Loa Loa (eye worm)	TK protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Loa Loa (eye worm)	TK/ROR protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	STE family protein kinase	0.0268	0.2934	1
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Trypanosoma cruzi	protein kinase, putative	0.0268	0.2934	0.9934
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0268	0.2934	0.2916
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.1743	0.557
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Schistosoma mansoni	protein kinase	0.0269	0.2951	0.5172
Trypanosoma brucei	Pseudokinase, putative	0.0268	0.2934	0.9934
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Entamoeba histolytica	serine/threonine kinase, putative	0.0268	0.2934	0.9939
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Leishmania major	protein kinase, putative	0.0268	0.2934	0.9934
Echinococcus granulosus	tyrosine protein kinase csk	0.0268	0.2934	0.512
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	TK/RYK protein kinase	0.0268	0.2934	0.5141
Echinococcus granulosus	tyrosine kinase	0.0268	0.2934	0.512
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0054	0.0245	0.0221
Brugia malayi	Receptor family ligand binding region containing protein	0.0268	0.2934	0.5141
Echinococcus multilocularis	tyrosine protein kinase csk	0.0268	0.2934	0.2916
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Brugia malayi	Tyrosine-protein kinase PR2	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0268	0.2934	0.2916
Loa Loa (eye worm)	TK/Met protein kinase	0.0268	0.2934	0.5141
Toxoplasma gondii	protein kinase	0.0268	0.2934	0.5448
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0268	0.2934	0.5141
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0054	0.0245	0.043
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Echinococcus multilocularis	tyrosine protein kinase csk	0.0268	0.2934	0.2916
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0054	0.0245	0.043
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Onchocerca volvulus		0.0268	0.2934	0.3005
Brugia malayi	SH2 domain containing protein	0.0268	0.2934	0.5141
Toxoplasma gondii	protein kinase domain-containing protein	0.0268	0.2934	0.5448
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Entamoeba histolytica	receptor protein kinase, putative	0.0268	0.2934	0.9939
Brugia malayi	hypothetical protein	0.0268	0.2934	0.5141
Trichomonas vaginalis	glucosylceramidase, putative	0.0264	0.2886	0.9822
Schistosoma mansoni	serine/threonine protein kinase	0.0268	0.2934	0.5141
Echinococcus multilocularis	integrin linked protein kinase	0.0268	0.2934	0.2916
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0054	0.0245	0.043
Schistosoma mansoni	protein tyrosine kinase	0.0268	0.2934	0.5141
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0054	0.0245	0.0389
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0268	0.2934	0.2916
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0268	0.2934	0.512
Trypanosoma brucei	protein kinase, putative	0.0269	0.2951	1
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0269	0.2951	0.5484
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Giardia lamblia	Kinase	0.0268	0.2934	0.5448
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0268	0.2934	0.512
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0054	0.0245	0.043
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0268	0.2934	0.2916
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.015	0.0263
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Brugia malayi	hypothetical protein	0.0268	0.2934	0.5141
Entamoeba histolytica	tyrosin kinase, putative	0.0268	0.2934	0.9939
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0268	0.2934	0.2916
Entamoeba histolytica	receptor protein kinase, putative	0.0268	0.2934	0.9939
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0268	0.2934	0.5141
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0268	0.2934	0.5141
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0268	0.2934	0.2916
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0054	0.0245	0.0221
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	TK/ACK protein kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	tyrosin kinase, putative	0.0268	0.2934	0.9939
Trichomonas vaginalis	glucosylceramidase, putative	0.0264	0.2886	0.9822
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0245	0.043
Onchocerca volvulus		0.0268	0.2934	0.3005
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0268	0.2934	0.9934
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0268	0.2934	0.2916
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0268	0.2934	0.512
Entamoeba histolytica	hypothetical protein	0.0268	0.2934	0.9939
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0268	0.2934	0.3005
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0054	0.0245	0.043
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0268	0.2934	0.9939
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Loa Loa (eye worm)	TK protein kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0268	0.2934	0.512
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0268	0.2934	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0268	0.2934	0.2916
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Echinococcus multilocularis	transfer RNA-Thr	0.0268	0.2934	0.2916
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Schistosoma mansoni	hypothetical protein	0.0268	0.2934	0.5141
Entamoeba histolytica	serine/threonine kinase, putative	0.0268	0.2934	0.9939
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0054	0.0245	0.0389
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0268	0.2934	0.2916
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0268	0.2934	0.512
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0268	0.2934	0.2916
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0269	0.2951	0.2934
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Onchocerca volvulus		0.0268	0.2934	0.3005
Loa Loa (eye worm)	TK/INSR protein kinase	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0203	0.0356
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	CAMK family protein kinase	0.0268	0.2934	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus granulosus	tyrosine kinase	0.0268	0.2934	0.512
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Echinococcus multilocularis	tyrosine protein kinase	0.0268	0.2934	0.2916
Entamoeba histolytica	hypothetical protein	0.0268	0.2934	0.9939
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0245	0.043
Echinococcus multilocularis	protein kinase	0.0268	0.2934	0.2916
Echinococcus granulosus	protein tyrosine kinase	0.0268	0.2934	0.512
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0268	0.2934	0.512
Brugia malayi	Furin-like cysteine rich region family protein	0.0268	0.2934	0.5141
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0392	0.4496	0.4483
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0268	0.2934	0.5448
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0054	0.0245	0.0221
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0268	0.2934	0.2916
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0268	0.2934	0.2916
Plasmodium falciparum	protein kinase, putative	0.0268	0.2934	0.9934
Brugia malayi	C-terminal src kinase protein 1	0.0268	0.2934	0.5141
Echinococcus granulosus	kinase suppressor of Ras 1	0.0268	0.2934	0.512
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Entamoeba histolytica	hypothetical protein	0.0268	0.2934	0.9939
Echinococcus multilocularis	tyrosine protein kinase csk	0.0268	0.2934	0.2916
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0268	0.2934	0.2916
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0268	0.2934	0.512
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.015	0.0263
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.015	0.0221
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0268	0.2934	0.2916
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0268	0.2934	0.2916
Schistosoma mansoni	protein kinase	0.0268	0.2934	0.5141
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0268	0.2934	0.512
Schistosoma mansoni	protein kinase	0.0268	0.2934	0.5141
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0488	0.5706	1
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Echinococcus granulosus	receptor type guanylyl cyclase	0.0268	0.2934	0.512
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0268	0.2934	0.2916
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0268	0.2934	0.512
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0268	0.2934	0.2916
Echinococcus multilocularis	heat shock protein 70	0.0268	0.2934	0.2916
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.015	0.0263
Entamoeba histolytica	hypothetical protein	0.0268	0.2934	0.9939
Loa Loa (eye worm)	TK/ALK protein kinase	0.0268	0.2934	0.5141
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.2934	1
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Loa Loa (eye worm)	PDE1B protein	0.0054	0.0245	0.043
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0268	0.2934	0.512
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Schistosoma mansoni	hypothetical protein	0.0037	0.0024	0.0043
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.015	0.0263
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0268	0.2934	0.2916
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.2934	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0268	0.2934	1
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Leishmania major	protein kinase, putative	0.0269	0.2951	1
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0488	0.5706	1
Onchocerca volvulus		0.0268	0.2934	0.3005
Loa Loa (eye worm)	TK protein kinase	0.0268	0.2934	0.5141
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.015	0.0263
Trichomonas vaginalis	protein kinase atn1, putative	0.0268	0.2934	1
Trichomonas vaginalis	TK family protein kinase	0.0268	0.2934	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0269	0.2951	0.5151
Loa Loa (eye worm)	TK/FER protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0268	0.2934	0.5141
Loa Loa (eye worm)	hypothetical protein	0.0268	0.2934	0.5141
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0268	0.2934	0.2916
Schistosoma mansoni	protein kinase	0.0268	0.2934	0.5141
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Echinococcus multilocularis	epidermal growth factor receptor	0.0268	0.2934	0.2916
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0054	0.0245	0.043
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0268	0.2934	0.512
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Brugia malayi	Protein kinase domain containing protein	0.0268	0.2934	0.5141
Trichomonas vaginalis	glucosylceramidase, putative	0.0264	0.2886	0.9822
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0268	0.2934	0.512
Echinococcus granulosus	c src tyrosine kinase	0.0268	0.2934	0.512
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0268	0.2934	0.9939
Schistosoma mansoni	tyrosine kinase	0.0268	0.2934	0.5141
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0268	0.2934	0.512
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0268	0.2934	0.5141
Entamoeba histolytica	tyrosine kinase, putative	0.0268	0.2934	0.9939
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0268	0.2934	0.512
Brugia malayi	Raf kinase	0.0268	0.2934	0.5141
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0268	0.2934	0.512
Onchocerca volvulus		0.0268	0.2934	0.3005
Entamoeba histolytica	protein kinase domain containing protein	0.0268	0.2934	0.9939
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Brugia malayi	Guanylyl cyclase protein 23	0.0268	0.2934	0.5141
Plasmodium vivax	protein kinase, putative	0.0268	0.2934	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0447	0.518	0.9074
Trichomonas vaginalis	TKL family protein kinase	0.0268	0.2934	1
Entamoeba histolytica	protein kinase, putative	0.0268	0.2934	0.9939
Entamoeba histolytica	tyrosin kinase, putative	0.0268	0.2934	0.9939
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0054	0.0245	0.043

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.45 nM	Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay	ChEMBL.	24400806
Inhibition (binding)	= 0 %	Inhibition of human platelet PDE2 at 10 uM	ChEMBL.	24400806
Inhibition (binding)	= 18 %	Inhibition of human platelet PDE3 at 10 uM	ChEMBL.	24400806
Inhibition (binding)	= 58 %	Inhibition of human platelet PDE5 at 10 uM	ChEMBL.	24400806

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3113737

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1830668