Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase-related | 0.0116 | 0.4946 | 0.4889 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0172 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.7641 | 0.7641 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1338 | 0.1338 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0168 | 0.7641 | 0.7615 |
Toxoplasma gondii | hypothetical protein | 0.0116 | 0.4946 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.1867 | 0.151 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.106 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1201 | 0.1201 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0116 | 0.4946 | 0.4724 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1867 | 0.1867 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1449 | 0.1449 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 1 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0283 | 0.0174 |
Echinococcus multilocularis | muscleblind protein | 0.0168 | 0.7641 | 0.7615 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0116 | 0.4946 | 0.4889 |
Echinococcus granulosus | carbonic anhydrase | 0.0116 | 0.4946 | 0.4889 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0067 | 0.2439 | 0.2354 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.4946 | 0.4946 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.4946 | 0.4946 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0067 | 0.2439 | 0.2354 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0952 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.4946 | 0.4946 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0214 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0116 | 0.4946 | 0.4889 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0952 | 0.0952 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.106 | 0.096 |
Echinococcus granulosus | carbonic anhydrase | 0.0116 | 0.4946 | 0.4889 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0952 | 0.0851 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0283 | 0.0174 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0214 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0116 | 0.4946 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0168 | 0.7641 | 0.7538 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0116 | 0.4946 | 0.4724 |
Echinococcus granulosus | muscleblind protein | 0.0168 | 0.7641 | 0.7615 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.3078 | 0.3078 |
Brugia malayi | Bromodomain containing protein | 0.0084 | 0.3326 | 0.3033 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0116 | 0.4946 | 0.4946 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.1867 | 0.151 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.1867 | 0.1867 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 0.4946 | 0.4889 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0172 | 0.0172 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.1197 | 0.0811 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0283 | 0.0174 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0116 | 0.4946 | 0.4724 |
Echinococcus multilocularis | carbonic anhydrase | 0.0116 | 0.4946 | 0.4889 |
Echinococcus multilocularis | carbonic anhydrase | 0.0116 | 0.4946 | 0.4889 |
Schistosoma mansoni | carbonic anhydrase | 0.0116 | 0.4946 | 0.4889 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0116 | 0.4946 | 0.4724 |
Schistosoma mansoni | bromodomain containing protein | 0.0071 | 0.2646 | 0.2564 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0116 | 0.4946 | 0.4889 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.7641 | 0.7641 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0116 | 0.4946 | 0.4889 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0116 | 0.4946 | 0.4724 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 uM | Antibacterial activity against acrB-deficient Escherichia coli MC4100 assessed as reduction in bacterial growth incubated for 6 to 8 hrs | ChEMBL. | 27184767 |
EC50 (ADMET) | > 100 uM | Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay | ChEMBL. | 27184767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.