Detailed information for compound 1830888

Basic information

Technical information
  • TDR Targets ID: 1830888
  • Name: N-[3-[2-ethyl-6-methyl-4-[5-(3,5,5-trimethyl- 6,7-dihydro-4H-2-benzothiophen-1-yl)-1,2,4-ox adiazol-3-yl]phenoxy]-2-hydroxypropyl]-2-hydr oxyacetamide
  • MW: 513.649 | Formula: C27H35N3O5S
  • H donors: 3 H acceptors: 5 LogP: 4.78 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCC(=O)NCC(COc1c(C)cc(cc1CC)c1noc(n1)c1sc(c2c1CCC(C2)(C)C)C)O
  • InChi: 1S/C27H35N3O5S/c1-6-17-10-18(9-15(2)23(17)34-14-19(32)12-28-22(33)13-31)25-29-26(35-30-25)24-20-7-8-27(4,5)11-21(20)16(3)36-24/h9-10,19,31-32H,6-8,11-14H2,1-5H3,(H,28,33)
  • InChiKey: NQFHQWJVXNDTJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[2-ethyl-6-methyl-4-[5-(3,5,5-trimethyl-6,7-dihydro-4H-2-benzothiophen-1-yl)-1,2,4-oxadiazol-3-yl]phenoxy]-2-hydroxy-propyl]-2-hydroxy-acetamide
  • N-[3-[2-ethyl-6-methyl-4-[5-(3,5,5-trimethyl-6,7-dihydro-4H-isobenzothiophen-1-yl)-1,2,4-oxadiazol-3-yl]phenoxy]-2-hydroxy-propyl]-2-hydroxy-acetamide
  • N-[3-[2-ethyl-6-methyl-4-[5-(3,5,5-trimethyl-6,7-dihydro-4H-2-benzothiophen-1-yl)-1,2,4-oxadiazol-3-yl]phenoxy]-2-hydroxy-propyl]-2-hydroxy-ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sphingosine-1-phosphate receptor 1 Starlite/ChEMBL References
Homo sapiens sphingosine-1-phosphate receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0275 0.051
Echinococcus multilocularis pyruvate kinase 0.0018 0.0072 0.0072
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0779 0.0918
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0496 0.1147
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0223 0.2504 0.295
Echinococcus multilocularis epidermal growth factor receptor 0.0316 0.3615 0.3615
Brugia malayi SRC-1 0.005 0.0456 0.0846
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0092 0.0093
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0309 0.067
Schistosoma mansoni tyrosine kinase 0.0171 0.1889 0.2225
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0684 0.1598
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0054 0.0012
Toxoplasma gondii hypothetical protein 0.0037 0.0301 0.0821
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.2469 0.2471
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0093 0.0094
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0093 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0061 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0162 0.0436
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0038 0.0038
Entamoeba histolytica hypothetical protein 0.0038 0.0308 0.0877
Echinococcus granulosus axis inhibition protein axin 0.002 0.0098 0.0115
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0047 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0098 0.0254
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0614 0.0724
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.045 0.045
Mycobacterium ulcerans hypothetical protein 0.0325 0.3724 1
Onchocerca volvulus Peroxidasin homolog 0.0028 0.0187 0.0347
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0196 0.0196
Loa Loa (eye worm) TK protein kinase 0.0035 0.0271 0.0271
Schistosoma mansoni hypothetical protein 0.0431 0.4974 0.5859
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0093 0.011
Echinococcus granulosus tyrosine kinase 0.0043 0.0365 0.043
Echinococcus granulosus carbonic anhydrase 0.0273 0.3097 0.3649
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0098 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0869 0.2454
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0093 0.0266
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0056 0.0065
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0063 0.1807
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0101 0.0101
Schistosoma mansoni single-minded 0.0051 0.0467 0.055
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0273 0.3097 0.5738
Schistosoma mansoni regulator of G protein signaling 0.002 0.0098 0.0115
Loa Loa (eye worm) hypothetical protein 0.0052 0.0477 0.0477
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0275 0.051
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0275 0.0276
Echinococcus granulosus geminin 0.0178 0.1978 0.233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0194 0.0528
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0101 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0061 0.0112
Schistosoma mansoni axis inhibition protein axin 0.002 0.0098 0.0115
Onchocerca volvulus Peroxidase homolog 0.0028 0.0187 0.0347
Echinococcus granulosus phd:f box containing protein 0.0017 0.0054 0.0064
Echinococcus multilocularis aldo keto reductase 0.0223 0.2504 0.2504
Onchocerca volvulus 0.0016 0.0051 0.0094
Brugia malayi MAP kinase sur-1 0.0054 0.0496 0.0918
Echinococcus multilocularis tyrosine protein kinase Src42A 0.005 0.0456 0.0456
Echinococcus granulosus cpg binding protein 0.0032 0.0238 0.028
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0365 0.4194 0.777
Leishmania major pyruvate kinase 0.0035 0.0275 0.062
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0275 0.051
Onchocerca volvulus 0.0038 0.0309 0.0572
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0365 0.4194 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.0112
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0306 0.0693
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0061 0.0071
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0275 0.0738
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0624 0.0735
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0063 0.0112
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0174 0.0403
Echinococcus granulosus NCK adaptor protein 0.0016 0.0044 0.0052
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0093 0.0173
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0365 0.4194 0.777
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.005 0.0456 0.0456
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0223 0.2504 0.7119
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0196 0.0362
Loa Loa (eye worm) CYP4Cod1 0.002 0.0101 0.0101
Entamoeba histolytica hypothetical protein 0.002 0.0098 0.0279
Loa Loa (eye worm) hypothetical protein 0.0273 0.3097 0.31
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0061 0.0071
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0098 0.0115
Echinococcus multilocularis pyruvate kinase 0.0035 0.0275 0.0275
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0594 0.07
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0056 0.0017
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0042 0.0362 0.0362
Echinococcus multilocularis c src tyrosine kinase 0.002 0.0092 0.0092
Brugia malayi hypothetical protein 0.0038 0.0308 0.0571
Loa Loa (eye worm) hypothetical protein 0.0062 0.0598 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0276 0.0762
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0051 0.0094
Trichomonas vaginalis aldo-keto reductase, putative 0.0223 0.2504 0.7119
Echinococcus multilocularis carbonic anhydrase 0.0273 0.3097 0.3097
Schistosoma mansoni tyrosine kinase 0.0167 0.1841 0.2169
Brugia malayi glutathione reductase 0.005 0.045 0.0833
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0042 0.0362 0.0362
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0308 0.0363
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0056 0.0056
Trichomonas vaginalis aldo/keto reductase, putative 0.0223 0.2504 0.7119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0191 0.0518
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0496 0.1388
Echinococcus multilocularis GPCR, family 2 0.0017 0.0056 0.0056
Echinococcus granulosus pyruvate kinase 0.0018 0.0072 0.0085
Echinococcus multilocularis tumor protein p63 0.0356 0.4084 0.4084
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0651 0.0651
Loa Loa (eye worm) RNA binding protein 0.0067 0.0651 0.0651
Echinococcus granulosus aldo keto reductase 0.0223 0.2504 0.295
Schistosoma mansoni potassium channel beta 0.0085 0.0869 0.1024
Trichomonas vaginalis aldo-keto reductase, putative 0.0223 0.2504 0.7119
Echinococcus granulosus epidermal growth factor receptor 0.0316 0.3615 0.4259
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0098 0.0098
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0022 0.0014
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0684 0.1946
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0021
Echinococcus granulosus voltage dependent calcium channel 0.0042 0.0362 0.0426
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0061 0.0112
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0309 0.0572
Onchocerca volvulus 0.0028 0.0196 0.0362
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0072 0.0071
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0051 0.006
Plasmodium falciparum aldehyde reductase, putative 0.0085 0.0869 0.2686
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0021 0.0021
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0456 0.0456
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0187 0.0187
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.1207 0.4703
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.005 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Mycobacterium tuberculosis Conserved protein 0.0085 0.0869 0.3322
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0056 0.0056
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0063 0.0034
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0365 0.0365
Schistosoma mansoni carbonic anhydrase-related 0.0273 0.3097 0.3649
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0042 0.0362 0.067
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0016 0.0044 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0061 0.0112
Loa Loa (eye worm) hypothetical protein 0.0037 0.0301 0.0301
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0239 0.0282
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0056 0.0065
Schistosoma mansoni tyrosine kinase 0.002 0.0092 0.0108
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0054 0.0054
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0042 0.0362 0.0649
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0467 0.055
Echinococcus multilocularis voltage gated potassium channel subunit 0.0085 0.0869 0.0869
Loa Loa (eye worm) runx1 0.0058 0.0553 0.0554
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0149 0.0425
Brugia malayi nuclear receptor NHR-88 0.0017 0.0061 0.0112
Echinococcus granulosus lamin 0.0028 0.0196 0.023
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.005 0.0456 0.0538
Leishmania major hypothetical protein, conserved 0.0017 0.0054 0.0091
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0223 0.2504 0.2504
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.0112
Echinococcus multilocularis pyruvate kinase 0.0018 0.0072 0.0072
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0275 0.0276
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0223 0.2504 0.2504
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0496 0.1147
Toxoplasma gondii aldose reductase, putative 0.0223 0.2504 0.8052
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0496 0.0496
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0051 0.0094
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0093 0.0185
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0651 0.0766
Trypanosoma cruzi aldo/keto reductase, putative 0.0085 0.0869 0.2041
Echinococcus granulosus tyrosine protein kinase shark 0.0012 0.0002 0.0002
Trichomonas vaginalis aldo-keto reductase, putative 0.0085 0.0869 0.2454
Plasmodium falciparum glutathione reductase 0.005 0.045 0.1309
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0047 0.0047
Echinococcus granulosus hypothetical protein 0.0223 0.2504 0.295
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0051 0.0051
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0061 0.0071
Brugia malayi hypothetical protein 0.002 0.0098 0.0182
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0527 0.0528
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.3514 1
Brugia malayi hypothetical protein 0.002 0.0098 0.0182
Trypanosoma brucei RNA helicase, putative 0.0424 0.4895 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0317 0.0317
Plasmodium falciparum LCCL domain-containing protein 0.0062 0.0598 0.1796
Schistosoma mansoni sodium/chloride dependent transporter 0.0095 0.0992 0.1169
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0223 0.2504 0.2504
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0651 0.0766
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0684 0.1598
Echinococcus granulosus carbonic anhydrase II 0.0365 0.4194 0.4941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0276 0.0762
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.045 0.053
Echinococcus multilocularis Ankyrin 0.0015 0.004 0.004
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0075 0.0088
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0061 0.0071
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0187 0.0347
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0098 0.0115
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0223 0.2504 0.2504
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0016 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0047 0.0047
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0061 0.0071
Brugia malayi isocitrate dehydrogenase 0.0017 0.0056 0.0103
Trichomonas vaginalis aldo-keto reductase, putative 0.0223 0.2504 0.7119
Entamoeba histolytica aldose reductase, putative 0.0223 0.2504 0.7126
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0061
Plasmodium falciparum carbonic anhydrase 0.0273 0.3097 1
Echinococcus multilocularis cpg binding protein 0.0032 0.0238 0.0238
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0063 0.0152
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Loa Loa (eye worm) blistered cuticle protein 3 0.0028 0.0187 0.0187
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0022 0.0014
Onchocerca volvulus 0.0223 0.2504 0.4639
Echinococcus multilocularis pyruvate kinase 0.0028 0.0188 0.0188
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0093 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0098 0.0254
Onchocerca volvulus 0.0062 0.0598 0.1108
Onchocerca volvulus 0.0028 0.0187 0.0347
Loa Loa (eye worm) hypothetical protein 0.0223 0.2504 0.2506
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0101 0.0202
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0061 0.0071
Schistosoma mansoni survival motor neuron protein 0.0051 0.0461 0.0544
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0085 0.0869 0.2686
Echinococcus granulosus tyrosine protein kinase Src64B 0.005 0.0456 0.0538
Echinococcus multilocularis RUN 0.0062 0.0598 0.0598
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0016 0.0051 0.1327
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0054 0.0064
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0496 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0098 0.0254
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0016 0.0019
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0223 0.2504 0.295
Loa Loa (eye worm) hypothetical protein 0.0062 0.0598 0.0599
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0093 0.0093
Plasmodium vivax multidomain scavenger receptor, putative 0.0062 0.0598 0.6687
Echinococcus granulosus tyrosine protein kinase Btk29A 0.002 0.0092 0.0108
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0093 0.0241
Brugia malayi Blistered cuticle protein 3 0.0028 0.0187 0.0347
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0624 0.1454
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0061 0.0061
Trichomonas vaginalis aldo-keto reductase, putative 0.0223 0.2504 0.7119
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0063 0.0154
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0016 0.0051 0.006
Schistosoma mansoni carbonic anhydrase 0.0273 0.3097 0.3649
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0275 0.0472
Onchocerca volvulus 0.0223 0.2504 0.4639
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.1207 0.4703
Schistosoma mansoni tyrosine kinase 0.0316 0.3615 0.4259
Echinococcus multilocularis peroxidasin 0.0028 0.0187 0.0187
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0063 0.0152
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.1358 0.5318
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0061 0.0061
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.1358 0.5392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0162 0.0436
Brugia malayi TAR-binding protein 0.0067 0.0651 0.1205
Echinococcus multilocularis geminin 0.0178 0.1978 0.1978
Entamoeba histolytica hypothetical protein 0.0038 0.0308 0.0877
Brugia malayi Peroxidasin 0.0028 0.0187 0.0347
Toxoplasma gondii hypothetical protein 0.0273 0.3097 1
Brugia malayi PAS domain containing protein 0.0051 0.0467 0.0865
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0223 0.2504 0.295
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0038 0.0071
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0223 0.2504 0.2504
Plasmodium falciparum glutathione reductase 0.0017 0.0063 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0174 0.0376
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0016 0.0051 0.006
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0275 0.076
Echinococcus multilocularis Protein lozenge 0.0058 0.0553 0.0553
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0624 0.1156
Schistosoma mansoni lipoxygenase 0.024 0.2714 0.3197
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.005 0.0456 0.0538
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0098 0.0182
Onchocerca volvulus 0.0013 0.0016 0.003
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0684 0.1267
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Echinococcus multilocularis pyruvate kinase 0.0035 0.0275 0.0275
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0016 0.0044 0.0044
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0552 0.1647
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0174 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0021
Plasmodium falciparum thioredoxin reductase 0.005 0.045 0.1309
Trypanosoma brucei protein kinase, putative 0.0054 0.0496 0.0926
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0174 0.0261
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0085 0.0869 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0223 0.2504 0.4639
Loa Loa (eye worm) doublecortin family protein 0.0062 0.0598 0.0599
Treponema pallidum sodium- and chloride- dependent transporter 0.0095 0.0992 0.2693
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0063 0.0112
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.042 0.042
Brugia malayi hypothetical protein 0.0017 0.0062 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3514 1
Loa Loa (eye worm) hypothetical protein 0.0273 0.3097 0.31
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0684 0.0684
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0056 0.0056
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0684 0.0806
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0054 0.0064
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0072 0.0071
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0223 0.2504 0.5954
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0239 0.0282
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.1644 0.6487
Schistosoma mansoni cpg binding protein 0.003 0.0217 0.0256
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0095 0.0992 0.1838
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0061 0.0112
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Schistosoma mansoni lamin 0.0028 0.0196 0.023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0061 0.0071
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0056 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0161 0.0434
Entamoeba histolytica hypothetical protein 0.0038 0.0308 0.0877
Brugia malayi Variant SH3 domain containing protein 0.0016 0.0044 0.0082
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0015
Trichomonas vaginalis aldo/keto reductase, putative 0.0223 0.2504 0.7119
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0047 0.0055
Schistosoma mansoni regulator of G protein signaling 0.002 0.0098 0.0115
Schistosoma mansoni regulator of G protein signaling 0.002 0.0098 0.0115
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0496 0.1388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0047 0.0108
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0651 0.0651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0162 0.0436
Loa Loa (eye worm) hypothetical protein 0.0024 0.0149 0.0149
Loa Loa (eye worm) oxidoreductase 0.0223 0.2504 0.2506
Entamoeba histolytica hypothetical protein 0.0038 0.0308 0.0877
Echinococcus multilocularis expressed protein 0.0393 0.4527 0.4527
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0016 0.0016
Plasmodium vivax glutathione reductase, putative 0.005 0.045 0.4874
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0624 0.0735
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0273 0.3097 0.5738
Loa Loa (eye worm) TK/INSR protein kinase 0.0103 0.1077 0.1078
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0009 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0174 0.0403
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0651 0.0766
Echinococcus granulosus death domain containing protein 0.0015 0.0038 0.0045
Onchocerca volvulus 0.0062 0.0598 0.1108
Schistosoma mansoni nck2/grb4 0.0016 0.0044 0.0052
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0075 0.0075
Trichomonas vaginalis aldo-keto reductase, putative 0.0085 0.0869 0.2454
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0187 0.0187
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.042 0.0779
Entamoeba histolytica alcohol dehydrogenase, putative 0.0085 0.0869 0.2474
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0187 0.0347
Loa Loa (eye worm) hypothetical protein 0.0853 0.9992 1
Brugia malayi Protein kinase domain containing protein 0.0103 0.1077 0.1995
Brugia malayi Doublecortin family protein 0.0062 0.0598 0.1108
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0098 0.0254
Mycobacterium ulcerans oxidoreductase 0.0223 0.2504 0.6668
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0098 0.0254
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0594 0.0594
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0496 0.1388
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0061 0.0071
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0051 0.006
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0063 0.0154
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0124 0.0159
Brugia malayi hypothetical protein 0.0062 0.0598 0.1108
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0223 0.2504 0.7119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0162 0.0436
Echinococcus granulosus aldo keto reductase 0.0223 0.2504 0.295
Echinococcus multilocularis tyrosine protein kinase Fgr 0.005 0.0456 0.0456
Onchocerca volvulus 0.025 0.283 0.5243
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0093 0.0185
Loa Loa (eye worm) oxidoreductase 0.0223 0.2504 0.2506
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Echinococcus multilocularis growth factor receptor bound protein 2 0.0016 0.0044 0.0044
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0042 0.0362 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0305 0.0845
Loa Loa (eye worm) TK/EGFR protein kinase 0.0316 0.3615 0.3618
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0038 0.0071
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0098 0.0182
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.023 0.023
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0284 0.0527
Leishmania major pyruvate kinase 0.0035 0.0275 0.062
Echinococcus multilocularis carbonic anhydrase II 0.0365 0.4194 0.4194
Brugia malayi hypoxia-induced factor 1 0.0159 0.1741 0.3226
Schistosoma mansoni pyruvate kinase 0.0035 0.0275 0.0325
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0171 0.1889 0.2225
Loa Loa (eye worm) hypothetical protein 0.0172 0.1899 0.1901
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0276 0.074
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0016 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0614 0.0615
Brugia malayi hypothetical protein 0.0159 0.1748 0.3239
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0016 0.0051 0.006
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0074
Echinococcus granulosus carbonic anhydrase 0.0273 0.3097 0.3649
Trichomonas vaginalis aldo-keto reductase, putative 0.0223 0.2504 0.7119
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0098 0.0115
Loa Loa (eye worm) hypothetical protein 0.0028 0.0196 0.0196
Loa Loa (eye worm) serotonin transporter b 0.0095 0.0992 0.0993
Brugia malayi protein-tyrosine kinase 0.0043 0.0365 0.0676
Onchocerca volvulus 0.0223 0.2504 0.4639
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0042 0.0362 0.0426
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0054 0.0054
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0223 0.2504 0.295
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0273 0.3097 0.5738
Loa Loa (eye worm) hypothetical protein 0.0466 0.5398 0.5402
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0061 0.0112
Brugia malayi hypothetical protein 0.0249 0.2816 0.5216
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.1358 0.5318
Mycobacterium leprae Conserved hypothetical protein 0.0138 0.1493 0.5936
Echinococcus granulosus expressed protein 0.0393 0.4527 0.5332
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0098 0.0098
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0061 0.0112
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0061 0.0112
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0056 0.0056
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0317 0.0374
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.4974 0.4974
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Onchocerca volvulus 0.0223 0.2504 0.4639
Loa Loa (eye worm) hypothetical protein 0.0249 0.2816 0.2818
Plasmodium falciparum pyruvate kinase 0.0035 0.0275 0.0738
Onchocerca volvulus 0.0223 0.2504 0.4639
Echinococcus granulosus epidermal growth factor receptor 0.0171 0.1889 0.2225
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0275 0.0276
Echinococcus granulosus arachidonate 5 lipoxygenase 0.024 0.2714 0.3197
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0614 0.0724
Echinococcus multilocularis voltage dependent calcium channel 0.0042 0.0362 0.0362
Trichomonas vaginalis aldo/keto reductase, putative 0.0223 0.2504 0.7119
Trypanosoma brucei aldo-keto reductase, putative 0.0223 0.2504 0.5068
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0098 0.0098
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0624 0.2321
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0042 0.0362 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0061 0.0061
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0095 0.0992 0.0993
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0095 0.0992 0.1169
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0223 0.2504 0.295
Echinococcus granulosus lamin dm0 0.0028 0.0196 0.023
Onchocerca volvulus 0.0028 0.0187 0.0347
Brugia malayi jmjC domain containing protein 0.0064 0.0614 0.1138
Schistosoma mansoni lipoxygenase 0.0128 0.1383 0.1629
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0624 0.0624
Brugia malayi Cytochrome P450 family protein 0.002 0.0101 0.0186
Schistosoma mansoni tyrosine kinase 0.0103 0.1077 0.1268
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0104 0.0104
Echinococcus granulosus dnaJ subfamily B 0.0431 0.4974 0.5859
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0218 0.0257
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0034
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.042 0.1196
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0056 0.0056
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0063 0.0041
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0063 0.0112
Schistosoma mansoni peroxidasin 0.0028 0.0187 0.022
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0054 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.042 0.1173
Schistosoma mansoni rab6-interacting 0.0062 0.0598 0.0704
Trichomonas vaginalis set domain proteins, putative 0.025 0.2829 0.8045
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0051 0.006
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.1207 0.4787
Brugia malayi nuclear hormone receptor 0.0017 0.0061 0.0112
Brugia malayi Pre-SET motif family protein 0.0032 0.0239 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0047 0.0108
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0223 0.2504 0.7119
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0098 0.0115
Echinococcus granulosus RUN 0.0062 0.0598 0.0704
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.042 0.0967
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0085 0.0869 0.2041
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0275 0.0897
Loa Loa (eye worm) hypothetical protein 0.0052 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Giardia lamblia Pyruvate kinase 0.0018 0.0072 0.0027
Brugia malayi hypothetical protein 0.0028 0.0187 0.0347
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.024 0.2714 0.2714
Leishmania major trypanothione reductase 0.005 0.045 0.1037
Brugia malayi Variant SH3 domain containing protein 0.0016 0.0044 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0191 0.0518
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0063 0.0041
Schistosoma mansoni microtubule-associated protein tau 0.0726 0.8489 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0042 0.0362 0.0826
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Echinococcus multilocularis lamin dm0 0.0028 0.0196 0.0196
Plasmodium vivax SET domain protein, putative 0.0032 0.0239 0.2306
Giardia lamblia Pyruvate kinase 0.0035 0.0275 0.0615
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0034
Schistosoma mansoni adapter molecule crk 0.0016 0.0044 0.0052
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0496 0.1147
Trichomonas vaginalis aldo-keto reductase, putative 0.0223 0.2504 0.7119
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0061 0.0071
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0187 0.0347
Loa Loa (eye worm) hypothetical protein 0.0037 0.0301 0.0301
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.0112
Giardia lamblia Fructose-bisphosphate aldolase 0.0308 0.3514 1
Trypanosoma brucei aldo/keto reductase, putative 0.0085 0.0869 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0223 0.0611
Brugia malayi hypothetical protein 0.0016 0.0051 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0194 0.0528
Echinococcus multilocularis insulin receptor 0.0103 0.1077 0.1077
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0054 0.0064
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0098 0.0182
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.002 0.0092 0.0092
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0047 0.0073
Schistosoma mansoni polycystin 1-related 0.0062 0.0598 0.0704
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.2823 0.2825
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0016 0.0016
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0275 0.1042
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0496 0.0584
Onchocerca volvulus 0.0223 0.2504 0.4639
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0015
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0223 0.2504 0.295
Echinococcus multilocularis tyrosine protein kinase Blk 0.0043 0.0365 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0276 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0061 0.0112
Brugia malayi Tyrosine-protein kinase abl-1 0.002 0.0092 0.017
Loa Loa (eye worm) RGS-3 protein 0.002 0.0098 0.0098
Onchocerca volvulus 0.0016 0.0051 0.0094
Brugia malayi hypothetical protein 0.0172 0.1899 0.3519
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0104 0.0192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3514 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.042 0.0967
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0223 0.2504 0.2504
Echinococcus multilocularis voltage dependent calcium channel 0.0042 0.0362 0.0362
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0061 0.0061
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0098 0.0098
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0016 0.0044 0.0044
Schistosoma mansoni coup transcription factor 0.0017 0.0061 0.0071
Loa Loa (eye worm) hypothetical protein 0.0042 0.0362 0.0362
Echinococcus granulosus insulin receptor 0.0103 0.1077 0.1268
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0365 0.4194 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0012 0.0002 0.0002
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0684 0.0684
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0187 0.0347
Echinococcus granulosus axis inhibition protein axin 0.002 0.0098 0.0115
Mycobacterium ulcerans hypothetical protein 0.0085 0.0869 0.2202
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0104 0.0104
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.042 0.0967
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0161 0.0434
Schistosoma mansoni hypothetical protein 0.0017 0.0056 0.0065
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0598 0.0704
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0098 0.0098
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0477 0.0562
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0061 0.0112
Plasmodium vivax aldehyde reductase, putative 0.0085 0.0869 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0061 0.0071
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0061 0.0071
Toxoplasma gondii transporter, cation channel family protein 0.0042 0.0362 0.102
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0098 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0276 0.0762
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0043 0.0365 0.043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0061 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3514 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0085 0.0869 0.087
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0223 0.2504 0.2504
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0306 0.0693
Brugia malayi Cytochrome P450 family protein 0.002 0.0101 0.0186
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0456 0.0538
Brugia malayi PXA domain containing protein 0.002 0.0098 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0276 0.0762
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0223 0.2504 0.2504
Schistosoma mansoni tyrosine kinase 0.0167 0.1841 0.2169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0061 0.0061
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0275 0.051
Leishmania major protein kinase, putative 0.0014 0.0022 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0047 0.0108
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0098 0.0182
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0273 0.3097 0.5738
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0098 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0239 0.0282
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0456 0.0538
Echinococcus multilocularis microtubule associated protein 2 0.0726 0.8489 0.8489
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0093 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0047 0.0108
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0275 0.0472
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.042 0.0967
Echinococcus granulosus c src tyrosine kinase 0.002 0.0092 0.0108
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0038 0.0045
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0016 0.0051 0.006
Echinococcus granulosus tar DNA binding protein 0.0067 0.0651 0.0766
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0275 0.051
Schistosoma mansoni hypothetical protein 0.0178 0.1978 0.233
Loa Loa (eye worm) hypothetical protein 0.0032 0.0239 0.024
Echinococcus multilocularis tyrosine protein kinase Src64B 0.005 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0017 0.0056 0.0056
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0061 0.0112
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0009 0.0016
Loa Loa (eye worm) hypoxia-induced factor 1 0.0159 0.1741 0.1743
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0072 0.0264
Onchocerca volvulus Dual oxidase homolog 0.0028 0.0187 0.0347
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0061 0.0112
Echinococcus granulosus voltage gated potassium channel subunit 0.0085 0.0869 0.1024
Plasmodium vivax thioredoxin reductase, putative 0.005 0.045 0.4874
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0061
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0061 0.0061
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0051 0.006
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0061 0.0071
Brugia malayi intermediate filament protein 0.0028 0.0196 0.0362
Schistosoma mansoni hypothetical protein 0.0273 0.3097 0.3649
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0275 0.076
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0174 0.15
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Schistosoma mansoni ap endonuclease 0.002 0.0093 0.011
Toxoplasma gondii thioredoxin reductase 0.005 0.045 0.1309
Schistosoma mansoni intermediate filament proteins 0.0028 0.0196 0.023
Onchocerca volvulus 0.0085 0.0869 0.161
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0056 0.0017
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0061 0.0071
Schistosoma mansoni hypothetical protein 0.0038 0.0308 0.0363
Trichomonas vaginalis aldo-keto reductase, putative 0.0223 0.2504 0.7119
Echinococcus granulosus aldo keto reductase 0.0223 0.2504 0.295
Schistosoma mansoni tyrosine kinase 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Echinococcus granulosus serotonin transporter 0.0095 0.0992 0.1169
Plasmodium falciparum thioredoxin reductase 0.0017 0.0063 0.0041
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.1358 0.5318
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.042 0.1173
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0336 0.0336
Brugia malayi Cytochrome P450 family protein 0.0031 0.023 0.0426
Echinococcus granulosus pyruvate kinase 0.0035 0.0275 0.0325
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0038 0.0038
Echinococcus granulosus pyruvate kinase 0.0018 0.0072 0.0085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Schistosoma mansoni tyrosine kinase 0.002 0.0092 0.0108
Brugia malayi jmjC domain containing protein 0.0062 0.0594 0.11
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0276 0.0762
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0239 0.0282
Schistosoma mansoni tyrosine kinase 0.0171 0.1889 0.2225
Echinococcus granulosus transcription factor Dp 1 0.004 0.0336 0.0396
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.0112
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0779 0.0779
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0051 0.006
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0054 0.0012
Schistosoma mansoni hypothetical protein 0.0015 0.0038 0.0045
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.1644 0.6543
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0098 0.0115
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0061 0.0112
Schistosoma mansoni growth factor receptor-bound protein 0.0016 0.0044 0.0052
Schistosoma mansoni tyrosine kinase 0.0167 0.1841 0.2169
Schistosoma mansoni hypothetical protein 0.0178 0.1978 0.233
Echinococcus multilocularis aldehyde reductase 0.0138 0.1493 0.1493
Trichomonas vaginalis aldo-keto reductase, putative 0.0223 0.2504 0.7119
Schistosoma mansoni rab6-interacting 0.0062 0.0598 0.0704
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0016 0.0021
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0496 0.0496
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0496 0.146
Trypanosoma brucei prostaglandin f synthase 0.0223 0.2504 0.5068
Treponema pallidum fructose-bisphosphate aldolase 0.0308 0.3514 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0061 0.0061
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0063 0.0112
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0016 0.0021
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0223 0.2504 0.2504
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0614 0.0724
Echinococcus multilocularis pyruvate kinase 0.0018 0.0072 0.0072
Schistosoma mansoni lozenge 0.0058 0.0553 0.0652
Entamoeba histolytica aldose reductase, putative 0.0223 0.2504 0.7126
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0223 0.2504 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.1207 0.4703
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0061 0.0112
Echinococcus multilocularis aldo keto reductase 0.0223 0.2504 0.2504
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0054 0.0064
Echinococcus multilocularis Polycystic kidney disease protein 0.0062 0.0598 0.0598
Echinococcus granulosus tumor protein p63 0.0356 0.4084 0.4811
Leishmania major hypothetical protein, conserved 0.0027 0.0174 0.0376
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0061 0.0061
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0051 0.006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0061 0.0061
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0275 0.0276
Leishmania major protein kinase, putative 0.0014 0.0022 0.0014
Onchocerca volvulus 0.0016 0.0051 0.0094
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0054 0.0064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0021
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0074
Schistosoma mansoni voltage-gated cation channel 0.0042 0.0362 0.0426
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.004 0.0047
Schistosoma mansoni growth factor receptor-bound protein 0.0016 0.0044 0.0052
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0223 0.2504 0.295
Loa Loa (eye worm) oxidoreductase 0.0223 0.2504 0.2506
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0047 0.0073
Schistosoma mansoni sodium-dependent amino acid transporter 0.0016 0.0051 0.006
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0594 0.07
Onchocerca volvulus 0.0159 0.1748 0.3239
Loa Loa (eye worm) TK protein kinase 0.0043 0.0365 0.0365
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0598 0.0598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0305 0.0845
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0223 0.2504 0.2504
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0093 0.0154
Onchocerca volvulus 0.0466 0.5398 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0235 0.0645
Brugia malayi Death domain containing protein 0.0015 0.0038 0.0071
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0054 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3514 1
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0651 0.0651
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0061 0.0071
Echinococcus multilocularis NCK adaptor protein 0.0016 0.0044 0.0044
Echinococcus granulosus GPCR family 2 0.0017 0.0056 0.0065
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0061
Plasmodium falciparum aldo-keto reductase, putative 0.0085 0.0869 0.2686
Brugia malayi steroid hormone receptor 0.0017 0.0061 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3514 1
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.2816 0.2816
Schistosoma mansoni pyruvate kinase 0.0018 0.0072 0.0085
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0187 0.0187
Schistosoma mansoni loxhd1 0.0062 0.0598 0.0704
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0098 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0305 0.0845
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0016 0.0051 0.0051
Brugia malayi Uncoordinated protein 44 0.0015 0.0038 0.0071
Echinococcus granulosus tyrosine protein kinase Blk 0.0043 0.0365 0.043
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0016 0.0021
Loa Loa (eye worm) oxidoreductase 0.0223 0.2504 0.2506
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0223 0.2504 0.295
Schistosoma mansoni hypothetical protein 0.0036 0.0284 0.0335
Onchocerca volvulus 0.0028 0.0187 0.0347
Echinococcus granulosus intermediate filament protein 0.0028 0.0196 0.023
Schistosoma mansoni hypothetical protein 0.0017 0.0056 0.0065
Brugia malayi ecdysteroid receptor 0.0017 0.0061 0.0112
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0496 0.1147
Mycobacterium leprae Possible oxidoreductase 0.0085 0.0869 0.3428
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0496 0.1253
Echinococcus granulosus Polycystic kidney disease protein 0.0062 0.0598 0.0704
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0061 0.0071
Echinococcus granulosus pyruvate kinase 0.0018 0.0072 0.0085
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0085 0.0869 0.2686
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0056 0.0017
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0051 0.0051
Brugia malayi Protein kinase domain containing protein 0.0016 0.0044 0.0081
Echinococcus granulosus aldehyde reductase 0.0138 0.1493 0.1759
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0275 0.2746
Schistosoma mansoni tyrosine kinase 0.0103 0.1077 0.1268
Brugia malayi Sex muscle abnormal protein 5 0.0016 0.0044 0.0082
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.042 0.1196
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0187 0.0187
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0056 0.0103
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0017 0.0056 0.0065
Loa Loa (eye worm) solute carrier family 6 member 4 0.0095 0.0992 0.0993
Schistosoma mansoni carbonic anhydrase-related 0.0273 0.3097 0.3649
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0051 0.0094
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.045 0.1037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0305 0.0845
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0056 0.0094
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0063 0.0034
Brugia malayi NADH-dependent xylose reductase 0.0085 0.0869 0.161
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.042 0.0421
Echinococcus multilocularis musashi 0.0028 0.0196 0.0196
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0085 0.0869 0.161
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0651 0.0766
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0093 0.0083
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0016 0.0021
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0056 0.0056
Schistosoma mansoni netrin receptor unc5 0.0015 0.0038 0.0045
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0021 0.0025
Loa Loa (eye worm) calcium channel 0.0042 0.0362 0.0362
Loa Loa (eye worm) oxidoreductase 0.0223 0.2504 0.2506
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0051 0.0051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0061 0.0071
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0054 0.0091
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0054 0.0064
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0624 0.1532
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0104 0.0122
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0061 0.0071
Toxoplasma gondii aldo-keto reductase 0.0085 0.0869 0.2686
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0104 0.0122
Echinococcus granulosus tyrosine protein kinase Lyn 0.0051 0.0462 0.0545
Schistosoma mansoni carbonic anhydrase-related 0.0273 0.3097 0.3649
Onchocerca volvulus Chorion peroxidase homolog 0.0028 0.0187 0.0347
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0634 0.0747
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0038 0.0045
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0239 0.0239
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0098 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0194 0.0528
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0061 0.0112
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0196 0.0196
Schistosoma mansoni pyruvate kinase 0.0035 0.0275 0.0325
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0093 0.0241
Brugia malayi RNA binding protein 0.0067 0.0651 0.1205
Loa Loa (eye worm) thioredoxin reductase 0.005 0.045 0.045
Schistosoma mansoni sodium/chloride dependent transporter 0.0017 0.0057 0.0067
Loa Loa (eye worm) norepinephrine transporter 0.0095 0.0992 0.0993
Schistosoma mansoni hypothetical protein 0.0062 0.0598 0.0704
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0016
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0187 0.0347
Brugia malayi hypothetical protein 0.0466 0.5398 1
Brugia malayi hypothetical protein 0.0027 0.0174 0.0321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3514 1
Brugia malayi jmjC domain containing protein 0.0017 0.0054 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0061 0.0112
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0056 0.0094
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0022 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0496 0.1388
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0095 0.0992 0.0993
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0056 0.0056
Schistosoma mansoni regulator of G protein signaling 0.002 0.0098 0.0115
Trypanosoma brucei cytochrome P450, putative 0.002 0.0101 0.0111
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0223 0.2504 0.2504
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0461 0.0855
Onchocerca volvulus 0.003 0.0217 0.0403
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.1207 0.4703
Loa Loa (eye worm) carbonic anhydrase 3 0.0365 0.4194 0.4198
Echinococcus granulosus voltage dependent calcium channel 0.0042 0.0362 0.0426
Plasmodium vivax JmjC domain containing protein 0.0017 0.0054 0.0045
Mycobacterium tuberculosis Probable reductase 0.0114 0.1207 0.4703
Trypanosoma cruzi aldo-keto reductase 0.0223 0.2504 0.5954
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0276 0.0762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.042 0.1173
Echinococcus multilocularis serotonin transporter 0.0095 0.0992 0.0992
Echinococcus multilocularis tyrosine protein kinase Abl 0.002 0.0092 0.0092
Echinococcus granulosus tyrosine protein kinase HCK 0.0035 0.0271 0.0319
Brugia malayi hypothetical protein 0.0062 0.0598 0.1108
Schistosoma mansoni pol-related 0.0223 0.2504 0.295
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0061
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0016 0.0016
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0273 0.3097 0.31
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0016 0.0051 0.0094
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0061
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0051 0.0051
Brugia malayi CXXC zinc finger family protein 0.003 0.0217 0.0403
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0061 0.0112
Loa Loa (eye worm) hypothetical protein 0.0042 0.0362 0.0362
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.042 0.0495
Onchocerca volvulus Peroxidase homolog 0.0028 0.0187 0.0347
Trichomonas vaginalis aldo-keto reductase, putative 0.0223 0.2504 0.7119
Onchocerca volvulus 0.0017 0.0061 0.0112
Echinococcus multilocularis tyrosine protein kinase Srms 0.0043 0.0365 0.0365
Schistosoma mansoni tyrosine kinase 0.005 0.0456 0.0538
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0056 0.0066
Schistosoma mansoni aldo-keto reductase 0.0223 0.2504 0.295
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.002 0.0092 0.0108
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.2816 0.3317
Mycobacterium tuberculosis Probable oxidoreductase 0.0223 0.2504 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0016 0.0044 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0496 0.0584
Leishmania major prostaglandin f synthase, putative 0.0223 0.2504 0.5954
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0103 0.1077 0.1077
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0684 0.0806
Brugia malayi jmjC domain containing protein 0.0017 0.0054 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3514 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0992 0.0993
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0061 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0061 0.0112
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Brugia malayi PXA domain containing protein 0.002 0.0098 0.0182
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0365 0.4194 0.4198
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0047 0.0055
Giardia lamblia GTOR 0.0047 0.042 0.1035
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0223 0.2504 0.4639
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0054 0.0054
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0042 0.0362 0.0362
Echinococcus multilocularis 0.0097 0.1013 0.1013
Schistosoma mansoni hypothetical protein 0.0017 0.0056 0.0065
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0051 0.006
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0223 0.2504 0.295
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0275 0.062
Brugia malayi Pre-SET motif family protein 0.022 0.2469 0.4574
Echinococcus multilocularis aldo keto reductase 0.0223 0.2504 0.2504
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0466 0.5398 0.5402
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0042 0.0362 0.0426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.0112
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0496 0.1147
Trichomonas vaginalis aldo-keto reductase, putative 0.0223 0.2504 0.7119
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0085 0.0869 0.2454
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0624 0.1532
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.1644 0.4318
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0098 0.0098
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0085 0.0869 0.1024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0061 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0161 0.0434
Brugia malayi Furin-like cysteine rich region family protein 0.0316 0.3615 0.6697
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0308 0.0308
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0056 0.0103
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0042 0.0362 0.0426
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0056 0.0019
Brugia malayi Thioredoxin reductase 0.005 0.045 0.0833
Loa Loa (eye worm) hypothetical protein 0.0028 0.0189 0.019
Entamoeba histolytica aldose reductase, putative 0.0223 0.2504 0.7126
Echinococcus multilocularis epidermal growth factor receptor 0.0171 0.1889 0.1889
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0098 0.0098
Giardia lamblia Aldose reductase 0.0223 0.2504 0.7074
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0684 0.1314
Loa Loa (eye worm) SRC-1 0.005 0.0456 0.0457
Onchocerca volvulus 0.0095 0.0992 0.1838
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0054 0.0054
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0651 0.1205
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0496 0.1147
Echinococcus granulosus microtubule associated protein 2 0.0726 0.8489 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0275 0.062
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0063 0.0112
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0051 0.006
Schistosoma mansoni aldo-keto reductase 0.0223 0.2504 0.295
Onchocerca volvulus Peroxidasin homolog 0.0028 0.0187 0.0347
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.042 0.077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.005 0.0456 0.0456
Schistosoma mansoni cpg binding protein 0.0032 0.0238 0.028
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0022 0.0014
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0063 0.0041
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0223 0.2504 0.5954
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0651 0.0766
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0056 0.0056
Leishmania major aldo-keto reductase-like protein 0.0223 0.2504 0.5954
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0047 0.0073
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0061 0.0071
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0061 0.0071
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0217 0.0218
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0101 0.0102
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0016 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0104 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0338 0.0939
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0098 0.0254
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0149 0.0149
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0056 0.0019
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0038
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0063 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.0112
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0063 0.0041
Schistosoma mansoni axis inhibition protein axin 0.002 0.0098 0.0115
Echinococcus granulosus pyruvate kinase 0.0035 0.0275 0.0325
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0365 0.4194 0.4941
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0093 0.0096
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0273 0.3097 0.5738
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0016 0.0019
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0056 0.0094
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0016 0.0051 0.006
Echinococcus multilocularis tyrosine protein kinase HCK 0.0035 0.0271 0.0271
Schistosoma mansoni ap endonuclease 0.002 0.0093 0.011
Giardia lamblia Aldose reductase 0.0223 0.2504 0.7074
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0098 0.0115
Trichomonas vaginalis aldo-keto reductase, putative 0.0223 0.2504 0.7119
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0101 0.0101
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0054 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0098 0.0254
Loa Loa (eye worm) voltage-dependent calcium channel 0.0042 0.0362 0.0362
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0306 0.0534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0047 0.0108
Echinococcus granulosus tyrosine protein kinase Fyn 0.005 0.0456 0.0538
Echinococcus multilocularis carbonic anhydrase 0.0273 0.3097 0.3097
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.045 0.1609
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0051 0.006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0063 0.0112
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0365 0.4194 0.4941
Schistosoma mansoni regulator of G protein signaling 0.002 0.0098 0.0115
Brugia malayi jmjC domain containing protein 0.0017 0.0054 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0061 0.0112
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0239 0.0282
Entamoeba histolytica hypothetical protein 0.002 0.0098 0.0279
Toxoplasma gondii exonuclease III APE 0.002 0.0093 0.014
Brugia malayi jmjC domain containing protein 0.0017 0.0054 0.0101
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.042 0.0495
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0063 0.0117
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0456 0.0456
Schistosoma mansoni lamin 0.0028 0.0196 0.023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0061 0.0071
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0098 0.0098
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0061 0.0071
Leishmania major cytochrome p450-like protein 0.002 0.0101 0.0202
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0482 0.0482
Leishmania major carbonic anhydrase-like protein 0.0365 0.4194 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0056 0.0062
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0093 0.0185
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0056 0.0103
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.3514 1
Echinococcus multilocularis carbonic anhydrase 0.0273 0.3097 0.3097
Schistosoma mansoni tyrosine kinase 0.005 0.0456 0.0538
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0103 0.1077 0.1268
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0223 0.2504 0.4639
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0284 0.0285
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0016 0.0021
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0042 0.0362 0.0426
Schistosoma mansoni cpg binding protein 0.0032 0.0238 0.028
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.042 0.077
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0308 0.0363
Trypanosoma brucei trypanothione reductase 0.005 0.045 0.0831
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.3514 1
Onchocerca volvulus 0.0051 0.0461 0.0855
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0482 0.0892
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0598 0.0704
Loa Loa (eye worm) glutathione reductase 0.005 0.045 0.045
Entamoeba histolytica hypothetical protein 0.002 0.0098 0.0279
Entamoeba histolytica protein kinase, putative 0.0035 0.0271 0.077
Onchocerca volvulus 0.0028 0.0196 0.0362
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0598 0.0598
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0054 0.0091
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0159 0.1748 0.175
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0187 0.0187
Echinococcus granulosus carbonic anhydrase 0.0273 0.3097 0.3649
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0054 0.0054
Echinococcus granulosus single minded 2 0.0038 0.0309 0.0363
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0054 0.0016
Entamoeba histolytica alcohol dehydrogenase, putative 0.0085 0.0869 0.2474
Echinococcus granulosus tyrosine protein kinase Src42A 0.005 0.0456 0.0538
Trichomonas vaginalis aldo-keto reductase, putative 0.0223 0.2504 0.7119
Echinococcus multilocularis aldo keto reductase 0.0223 0.2504 0.2504
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.1207 0.4703
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0275 0.058
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0038 0.0045
Onchocerca volvulus 0.0052 0.0477 0.0883
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0305 0.0845
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0098 0.0115
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Chlamydia trachomatis pyruvate kinase 0.0035 0.0275 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0223 0.2504 0.4639
Brugia malayi follicle stimulating hormone receptor 0.025 0.2823 0.523
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0056 0.0056
Trichomonas vaginalis aldo-keto reductase, putative 0.0085 0.0869 0.2454
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0174 0.0403
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0054 0.0054
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0016 0.0051 0.0051
Echinococcus multilocularis lamin 0.0028 0.0196 0.0196
Trypanosoma brucei carbonic anhydrase-like protein 0.0365 0.4194 0.8554
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0047 0.0087
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0061
Echinococcus granulosus peroxidasin 0.0028 0.0187 0.022
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0104 0.0122
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0051 0.006
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0016 0.0051 0.0051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0482 0.0892
Onchocerca volvulus 0.0032 0.0239 0.0444
Schistosoma mansoni hypothetical protein 0.0424 0.4895 0.5767
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0239 0.0619
Schistosoma mansoni peroxidasin 0.0028 0.0187 0.022
Schistosoma mansoni hypothetical protein 0.0051 0.0461 0.0544
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0061 0.0061
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0684 0.1598
Trypanosoma cruzi aldo/keto reductase, putative 0.0223 0.2504 0.5954
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0098 0.0115
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0038 0.0038
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0098 0.0098
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0093 0.0522
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0496 0.0926
Echinococcus granulosus Ankyrin 0.0015 0.004 0.0047

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 1.5 nM Agonist activity at human recombinant S1P1 receptor expressed in CHO cells assessed as membrane-bound 35S-GTPgammaS incubated 30 mins prior to substrate addition measured after 1 hr by topcount scintillation counting analysis ChEMBL. 24345087
EC50 (binding) = 122 nM Agonist activity at human recombinant S1P3 receptor expressed in CHO cells assessed as membrane-bound 35S-GTPgammaS incubated 30 mins prior to substrate addition measured after 1 hr by topcount scintillation counting analysis ChEMBL. 24345087
Emax (binding) > 85 % Agonist activity at human recombinant S1P3 receptor expressed in CHO cells assessed as membrane-bound 35S-GTPgammaS at 10 uM incubated 30 mins prior to substrate addition measured after 1 hr by topcount scintillation counting analysis relative to control ChEMBL. 24345087
Emax (binding) > 85 % Agonist activity at human recombinant S1P1 receptor expressed in CHO cells assessed as membrane-bound 35S-GTPgammaS at 10 uM incubated 30 mins prior to substrate addition measured after 1 hr by topcount scintillation counting analysis relative to control ChEMBL. 24345087

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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