Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0363 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1403 | 1 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1246 | 0.8492 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0363 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 30 uM | Inhibition of Enoyl-ACP reductase from S. pneumoniae | ChEMBL. | 12109908 |
IC50 (binding) | > 30 uM | Inhibition of Enoyl-ACP reductase from S. pneumoniae | ChEMBL. | 12109908 |
IC50 (binding) | = 93.7 uM | Concentration of the compound required for the 50% inhibition of enoyl-ACP reductase from S. aureus was determined. | ChEMBL. | 12109908 |
IC50 (binding) | = 93.7000000000001 uM | Concentration of the compound required for the 50% inhibition of enoyl-ACP reductase from S. aureus was determined. | ChEMBL. | 12109908 |
IC50 (binding) | = 97.4 uM | Concentration of the compound required for the 50% inhibition of enoyl-ACP reductase from H. influenzae was determined. | ChEMBL. | 12109908 |
MIC (functional) | > 64 ug ml-1 | Minimum concentration of the compound required for inhibition of S. aureus was determined. | ChEMBL. | 12109908 |
MIC (functional) | > 64 ug ml-1 | Minimum concentration of the compound required for inhibition of H. influenzae was determined. | ChEMBL. | 12109908 |
MIC (functional) | > 64 ug ml-1 | Minimum concentration of the compound required for inhibition of E. faecalis was determined. | ChEMBL. | 12109908 |
MIC (functional) | > 64 ug ml-1 | Minimum concentration of the compound required for inhibition of S. pneumoniae was determined. | ChEMBL. | 12109908 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.