Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MDM2 proto-oncogene, E3 ubiquitin protein ligase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | GPCR, family 2 | 0.0036 | 0.1872 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.6238 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0064 | 0.4681 | 0.4681 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0064 | 0.4681 | 0.4681 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0064 | 0.4681 | 0.4681 |
Echinococcus granulosus | GPCR family 2 | 0.0036 | 0.1872 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0064 | 0.4681 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0036 | 0.1872 | 0.1872 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0079 | 0.6238 | 0.6238 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1872 | 0.3 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1872 | 0.3 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1872 | 0.1872 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1872 | 0.3 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0064 | 0.4681 | 0.4681 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0064 | 0.4681 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1872 | 0.3 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0064 | 0.4681 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.6238 | 0.6238 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0036 | 0.1872 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0064 | 0.4681 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0064 | 0.4681 | 0.4681 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0036 | 0.1872 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0036 | 0.1872 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0036 | 0.1872 | 0.1872 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0036 | 0.1872 | 0.1872 |
Leishmania major | cytochrome p450-like protein | 0.0064 | 0.4681 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.279 | 0.279 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0036 | 0.1872 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.2 uM | Inhibition of human MDM2/p53 interaction by fluorescence polarization assay | ChEMBL. | 24486134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.