Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 23 uM | Binding affinity to electric eel AChE peripheral anionic site assessed as concentration required for decreasing initial fluorescence intensity of AChE-propidium complex by spectrofluorometric analysis | ChEMBL. | 24389509 |
IC50 (binding) | = 0.532 uM | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 5 mins by Ellman's method | ChEMBL. | 24389509 |
IC50 (binding) | = 0.556 uM | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method | ChEMBL. | 24389509 |
IC50 (binding) | = 1.37 uM | Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 5 mins by Ellman's method | ChEMBL. | 24389509 |
Inhibition (binding) | <= 16 % | Inhibition of amyloid beta (1 to 42) aggregation (unknown origin) at 10 uM relative to control | ChEMBL. | 24389509 |
Kd (binding) | = 2.18 uM | Displacement of propidium from electric eel AChE peripheral anionic site assessed as decrease in fluorescence intensity by spectrofluorometric analysis | ChEMBL. | 24389509 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.