Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0172 | 0.3562 | 0.2831 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.1019 | 0.5 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0172 | 0.3562 | 0.2831 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0172 | 0.3562 | 0.2831 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0193 | 0.4251 | 0.3599 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0172 | 0.3562 | 0.2831 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0172 | 0.3562 | 0.2831 |
Brugia malayi | nuclear receptor RXR | 0.0193 | 0.4251 | 0.3599 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.4251 | 0.4251 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0172 | 0.3562 | 0.2831 |
Schistosoma mansoni | nuclear hormone receptor | 0.0172 | 0.3562 | 0.2831 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Leishmania major | hexokinase, putative | 0.0096 | 0.1019 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.1019 | 0.1019 |
Onchocerca volvulus | 0.0172 | 0.3562 | 0.2831 | |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0172 | 0.3562 | 0.2831 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0172 | 0.3562 | 0.2831 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Brugia malayi | nuclear receptor RXR | 0.0172 | 0.3562 | 0.2831 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0172 | 0.3562 | 0.2831 |
Brugia malayi | nuclear receptor NHR-88 | 0.0172 | 0.3562 | 0.2831 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0193 | 0.4251 | 0.3599 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.1019 | 0.1019 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0172 | 0.3562 | 0.2831 |
Brugia malayi | hypothetical protein | 0.0172 | 0.3562 | 0.2831 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0172 | 0.3562 | 0.3562 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.1019 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0172 | 0.3562 | 0.2831 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 0.1019 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0172 | 0.3562 | 0.3562 |
Trypanosoma brucei | hexokinase | 0.0096 | 0.1019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0172 | 0.3562 | 0.2831 |
Toxoplasma gondii | hexokinase | 0.0096 | 0.1019 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0172 | 0.3562 | 0.2831 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0172 | 0.3562 | 0.2831 |
Brugia malayi | hypothetical protein | 0.0193 | 0.4251 | 0.3599 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0172 | 0.3562 | 0.2831 |
Brugia malayi | tailless protein | 0.0172 | 0.3562 | 0.2831 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.4251 | 0.4251 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.1019 | 0.5 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0172 | 0.3562 | 0.2831 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.1019 | 0.5 |
Brugia malayi | conserved hypotetical protein | 0.0172 | 0.3562 | 0.2831 |
Brugia malayi | nuclear hormone receptor | 0.0172 | 0.3562 | 0.2831 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0193 | 0.4251 | 0.4251 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0172 | 0.3562 | 0.2831 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0193 | 0.4251 | 0.3599 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.4251 | 0.4251 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 0.1019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0193 | 0.4251 | 0.3599 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Brugia malayi | ecdysone receptor | 0.0172 | 0.3562 | 0.2831 |
Schistosoma mansoni | zinc finger protein | 0.0172 | 0.3562 | 0.2831 |
Brugia malayi | hypothetical protein | 0.0193 | 0.4251 | 0.3599 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.4251 | 0.4251 |
Leishmania major | hexokinase, putative | 0.0096 | 0.1019 | 0.5 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0172 | 0.3562 | 0.2831 |
Schistosoma mansoni | nuclear hormone receptor | 0.0172 | 0.3562 | 0.2831 |
Loa Loa (eye worm) | DR-78 | 0.0172 | 0.3562 | 0.3562 |
Brugia malayi | nuclear receptor NHR-67 | 0.0172 | 0.3562 | 0.2831 |
Schistosoma mansoni | nuclear receptor | 0.0172 | 0.3562 | 0.2831 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0193 | 0.4251 | 0.3599 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.1019 | 0.1019 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Brugia malayi | hypothetical protein | 0.0172 | 0.3562 | 0.2831 |
Onchocerca volvulus | 0.0172 | 0.3562 | 0.2831 | |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0172 | 0.3562 | 0.2831 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0172 | 0.3562 | 0.2831 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.1019 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0172 | 0.3562 | 0.2831 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.1019 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.1019 | 0.5 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0172 | 0.3562 | 0.2831 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0172 | 0.3562 | 0.3562 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.4251 | 0.4251 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0172 | 0.3562 | 0.2831 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0193 | 0.4251 | 0.3599 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0172 | 0.3562 | 0.2831 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3562 | 0.3562 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.316 uM | Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled GK measured after 2 to 4 hrs by Alpha Screen assay | ChEMBL. | 24405213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.