Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.4658 | 0.4022 |
Echinococcus granulosus | carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2982 | 0.2925 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 0.8014 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1064 | 0.0992 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0092 | 0.3107 | 0.3052 |
Echinococcus multilocularis | carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.306 | 0.3004 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0166 | 0.8014 | 1 |
Onchocerca volvulus | 0.0146 | 0.6693 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1064 | 0.0992 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.306 | 0.0111 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.009 | 0.2982 | 0.2146 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0098 | 0.3514 | 0.4385 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0092 | 0.3107 | 0.2287 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.3514 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.0166 | 0.8014 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.8014 | 1 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.009 | 0.2982 | 0.2146 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2982 | 0.2919 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.009 | 0.2982 | 0.2146 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0092 | 0.3107 | 0.2287 |
Leishmania major | monoglyceride lipase, putative | 0.0166 | 0.8014 | 0.717 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0166 | 0.8014 | 0.5 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2982 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0166 | 0.8014 | 0.717 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0092 | 0.3107 | 0.2287 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0098 | 0.3514 | 0.4385 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0092 | 0.3107 | 0.3052 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.009 | 0.2982 | 0.2146 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0092 | 0.306 | 0.2233 |
Toxoplasma gondii | hypothetical protein | 0.0092 | 0.3107 | 0.8438 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0092 | 0.306 | 0.2233 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.3107 | 0.2287 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 0.8014 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0092 | 0.306 | 0.0111 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0098 | 0.3514 | 0.4385 |
Echinococcus multilocularis | carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0166 | 0.8014 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0092 | 0.3107 | 0.3052 |
Echinococcus granulosus | carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 0.8014 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.306 | 0.0111 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.009 | 0.2982 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1064 | 0.0992 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0092 | 0.3107 | 0.2287 |
Plasmodium falciparum | lysophospholipase, putative | 0.0166 | 0.8014 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0098 | 0.3514 | 0.1058 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.4658 | 0.4022 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.6693 | 0.6299 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0166 | 0.8014 | 0.717 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.3107 | 0.2287 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0166 | 0.8014 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1064 | 0.0992 |
Plasmodium falciparum | carbonic anhydrase | 0.0092 | 0.3107 | 0.0249 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0166 | 0.8014 | 0.717 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.8014 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0092 | 0.306 | 0.2233 |
Mycobacterium ulcerans | hypothetical protein | 0.0166 | 0.8014 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0092 | 0.3107 | 0.3052 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.4658 | 0.4022 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.3514 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Plasmodium falciparum | lysophospholipase, putative | 0.0166 | 0.8014 | 1 |
Brugia malayi | hypothetical protein | 0.0146 | 0.6693 | 0.6299 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0166 | 0.8014 | 1 |
Plasmodium vivax | PST-A protein | 0.0166 | 0.8014 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 0.8014 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.3107 | 0.3052 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0092 | 0.306 | 0.0111 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1064 | 0.0992 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.306 | 0.3818 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.3107 | 0.2287 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0166 | 0.8014 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0166 | 0.8014 | 1 |
Plasmodium falciparum | esterase, putative | 0.0166 | 0.8014 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0092 | 0.306 | 0.2233 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0092 | 0.3107 | 0.2287 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0092 | 0.3107 | 0.2287 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of FLAG-tagged TNAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay | ChEMBL. | 24412070 |
IC50 (binding) | > 100 uM | Inhibition of mouse duodenal-specific FLAG-tagged IAP expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay | ChEMBL. | 24412070 |
IC50 (binding) | > 100 uM | Inhibition of FLAG-tagged PLAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay | ChEMBL. | 24412070 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.