Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0009 | 0.0009 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0813 | 0.5177 | 0.5173 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | hypothetical protein | 0.0813 | 0.5177 | 0.5173 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Schistosoma mansoni | nuclear receptor | 0.0726 | 0.4599 | 0.4594 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0726 | 0.4599 | 0.4599 |
Brugia malayi | tailless protein | 0.0726 | 0.4599 | 0.4594 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0726 | 0.4599 | 0.4594 |
Onchocerca volvulus | 0.0726 | 0.4599 | 0.4594 | |
Loa Loa (eye worm) | hypothetical protein | 0.0813 | 0.5177 | 0.5173 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0813 | 0.5177 | 0.5177 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | conserved hypotetical protein | 0.0726 | 0.4599 | 0.4594 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0813 | 0.5177 | 0.5173 |
Schistosoma mansoni | nuclear receptor | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0726 | 0.4599 | 0.4599 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0813 | 0.5177 | 0.5173 |
Brugia malayi | nuclear receptor NHR-67 | 0.0726 | 0.4599 | 0.4594 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | hypothetical protein | 0.0813 | 0.5177 | 0.5173 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0726 | 0.4599 | 0.4594 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0726 | 0.4599 | 0.4594 |
Onchocerca volvulus | 0.0726 | 0.4599 | 0.4594 | |
Brugia malayi | Pre-SET motif family protein | 0.0244 | 0.1394 | 0.1387 |
Brugia malayi | nuclear hormone receptor | 0.0726 | 0.4599 | 0.4594 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0726 | 0.4599 | 0.4599 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0726 | 0.4599 | 0.4594 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0726 | 0.4599 | 0.4599 |
Brugia malayi | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.0009 | 0.5 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0726 | 0.4599 | 0.4594 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | nuclear receptor RXR | 0.0726 | 0.4599 | 0.4594 |
Schistosoma mansoni | nuclear hormone receptor | 0.0726 | 0.4599 | 0.4594 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0726 | 0.4599 | 0.4594 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0726 | 0.4599 | 0.4594 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0813 | 0.5177 | 0.5173 |
Schistosoma mansoni | nuclear hormone receptor | 0.0726 | 0.4599 | 0.4594 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | ecdysone receptor | 0.0726 | 0.4599 | 0.4594 |
Schistosoma mansoni | zinc finger protein | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0726 | 0.4599 | 0.4594 |
Loa Loa (eye worm) | hypothetical protein | 0.0813 | 0.5177 | 0.5173 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.0009 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0277 | 0.1618 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Loa Loa (eye worm) | DR-78 | 0.0726 | 0.4599 | 0.4594 |
Onchocerca volvulus | 0.0277 | 0.1618 | 0.1611 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0726 | 0.4599 | 0.4594 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0813 | 0.5177 | 0.5173 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0813 | 0.5177 | 0.5173 |
Loa Loa (eye worm) | hypothetical protein | 0.0813 | 0.5177 | 0.5173 |
Loa Loa (eye worm) | hypothetical protein | 0.0813 | 0.5177 | 0.5173 |
Loa Loa (eye worm) | hypothetical protein | 0.0813 | 0.5177 | 0.5173 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0726 | 0.4599 | 0.4594 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0726 | 0.4599 | 0.4599 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0726 | 0.4599 | 0.4599 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0726 | 0.4599 | 0.4594 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0726 | 0.4599 | 0.4594 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0726 | 0.4599 | 0.4594 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0726 | 0.4599 | 0.4594 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.4599 | 0.4594 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0726 | 0.4599 | 0.4594 |
Brugia malayi | nuclear receptor RXR | 0.0813 | 0.5177 | 0.5173 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0244 | 0.1394 | 0.1387 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1840 nM | Antagonist activity at human CB1 receptor stably expressed in CHO cells co-expressing co-expressing Ga15/16 assessed as calcium current after 45 mins by fluo-4 AM assay | ChEMBL. | 24445310 |
IC50 (binding) | = 4090 nM | Antagonist activity at CB2 receptor (unknown origin) stably expressed in CHO cells co-expressing co-expressing Ga15/16 assessed as calcium current after 45 mins by fluo-4 AM assay | ChEMBL. | 24445310 |
Inhibition (binding) | = 98 % | Antagonist activity at human CB1 receptor stably expressed in CHO cells co-expressing co-expressing Ga15/16 assessed as calcium current at 10 uM after 45 mins by fluo-4 AM assay relative to basal control | ChEMBL. | 24445310 |
Inhibition (binding) | = 130.8 % | Antagonist activity at CB2 receptor (unknown origin) stably expressed in CHO cells co-expressing co-expressing Ga15/16 assessed as calcium current at 10 uM after 45 mins by fluo-4 AM assay relative to basal control | ChEMBL. | 24445310 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.