Detailed information for compound 1832726

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 742.953 | Formula: C38H46N8O4S2
  • H donors: 4 H acceptors: 6 LogP: 5.82 Rotable bonds: 23
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@H](Cc1ccccc1)CC[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)N(Cc1csc(n1)C(C)C)C)OCc1cncs1
  • InChi: 1S/C38H46N8O4S2/c1-26(2)36-43-32(23-51-36)21-46(3)37(48)45-34(18-31-19-39-24-41-31)35(47)42-29(16-27-10-6-4-7-11-27)14-15-30(17-28-12-8-5-9-13-28)44-38(49)50-22-33-20-40-25-52-33/h4-13,19-20,23-26,29-30,34H,14-18,21-22H2,1-3H3,(H,39,41)(H,42,47)(H,44,49)(H,45,48)/t29-,30-,34-/m0/s1
  • InChiKey: SBBZCSSPXOWAMS-RRURFNPQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Brugia malayi Tubulin alpha chain 0.0058 0.0269 0.1001
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0000043503 0.0000043503
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0268 0.0999
Trypanosoma cruzi aldo/keto reductase, putative 0.0436 0.2685 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0064 0.0309 0.0841
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.0309 0.0309
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0038 0.0141
Trypanosoma brucei alpha tubulin, putative 0.0075 0.038 0.1416
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0039 0.0151 0.0561
Echinococcus multilocularis thyroid hormone receptor alpha 0.0158 0.091 0.091
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.0309 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0309 0.032
Loa Loa (eye worm) ABC transporter 0.0033 0.0113 0.042
Trypanosoma brucei ABC transporter, putative 0.0039 0.0151 0.0561
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Trypanosoma cruzi aldo-keto reductase 0.0436 0.2685 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0055 0.0167
Trypanosoma cruzi epsilon tubulin, putative 0.0133 0.0748 0.2784
Schistosoma mansoni hypothetical protein 0.0064 0.0309 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0309 0.032
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0147 0.0147
Brugia malayi hypothetical protein 0.0064 0.0309 0.1149
Echinococcus multilocularis tubulin delta chain 0.0058 0.0269 0.0269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0778 0.0778
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0309 0.0443
Leishmania major delta tubulin, putative 0.0058 0.0269 0.1001
Brugia malayi ecdysteroid receptor 0.003 0.0093 0.0346
Trichomonas vaginalis aldo-keto reductase, putative 0.0436 0.2685 1
Echinococcus granulosus Tubulin alpha 1 chain 0.019 0.1111 0.1595
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0245 0.1462 0.1462
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0436 0.2685 0.3855
Schistosoma mansoni hypothetical protein 0.0166 0.0959 0.0994
Schistosoma mansoni hypothetical protein 0.0166 0.0959 0.0994
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.0309 0.0309
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0093 0.0093
Schistosoma mansoni pol-related 0.0436 0.2685 0.2783
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0229 0.0237
Plasmodium falciparum aldo-keto reductase, putative 0.0126 0.0708 0.5011
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0038 0.0054
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0346
Brugia malayi AKH receptor 0.0064 0.0309 0.1149
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0309 0.032
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Echinococcus multilocularis voltage gated potassium channel subunit 0.0126 0.0708 0.0708
Loa Loa (eye worm) BEN-1 protein 0.0237 0.1412 0.5256
Loa Loa (eye worm) oxidoreductase 0.0436 0.2685 0.9994
Schistosoma mansoni chromobox protein 0.0067 0.0331 0.0343
Giardia lamblia Epsilon tubulin 0.0058 0.0269 0.0922
Brugia malayi follicle stimulating hormone receptor 0.0064 0.0309 0.1149
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0207
Echinococcus granulosus tubulin subunit TubB 0.019 0.1111 0.1595
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0346
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Trypanosoma brucei alpha tubulin 0.019 0.1111 0.4136
Onchocerca volvulus 0.0075 0.038 0.1117
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0023 0.0023
Plasmodium vivax tubulin gamma chain, putative 0.0133 0.0748 0.5294
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0048 0.5
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0229 0.0853
Schistosoma mansoni tubulin subunit alpha 0.019 0.1111 0.1151
Brugia malayi Dopamine receptor protein 2 0.0064 0.0309 0.1149
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0312 0.0324
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.0236
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0021 0.003
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0229 0.0853
Echinococcus multilocularis Tubulin alpha 1 chain 0.019 0.1111 0.1111
Trichomonas vaginalis tubulin epsilon chain, putative 0.0058 0.0269 0.0967
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0309 0.0309
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0093 0.0133
Onchocerca volvulus 0.0038 0.0147 0.0219
Loa Loa (eye worm) alpha-tubulin 0.019 0.1111 0.4134
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0312 0.0324
Trichomonas vaginalis tubulin gamma chain, putative 0.0237 0.1412 0.5241
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.1414 0.5263
Echinococcus granulosus tubulin delta chain 0.0058 0.0269 0.0386
Schistosoma mansoni biogenic amine receptor 0.0064 0.0309 0.032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.068 0.0704
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0436 0.2685 0.3855
Toxoplasma gondii aldehyde dehydrogenase 0.0245 0.1462 0.5444
Echinococcus multilocularis tubulin epsilon chain 0.0133 0.0748 0.0748
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0309 0.032
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0229 0.0818
Trichomonas vaginalis tubulin beta chain, putative 0.019 0.1111 0.4114
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus granulosus 7tm_1 domain containing protein 0.0064 0.0309 0.0443
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0309 0.0309
Schistosoma mansoni aldo-keto reductase 0.0436 0.2685 0.2783
Trichomonas vaginalis tubulin alpha chain, putative 0.0075 0.038 0.1383
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0236
Echinococcus multilocularis cpg binding protein 0.0061 0.0289 0.0289
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0064 0.0309 0.032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0843 0.3138
Schistosoma mansoni cpg binding protein 0.0058 0.0268 0.0278
Echinococcus multilocularis neuropeptide receptor 0.0064 0.0309 0.0309
Toxoplasma gondii exonuclease III APE 0.0019 0.0023 0.0087
Echinococcus granulosus tar DNA binding protein 0.0064 0.0312 0.0449
Onchocerca volvulus 0.0064 0.0309 0.0841
Toxoplasma gondii aldo-keto reductase 0.0126 0.0708 0.2636
Trypanosoma brucei zeta tubulin, putative 0.0058 0.0269 0.1001
Echinococcus granulosus voltage gated potassium channel subunit 0.0126 0.0708 0.1016
Trichomonas vaginalis aldo-keto reductase, putative 0.0436 0.2685 1
Brugia malayi CXXC zinc finger family protein 0.0058 0.0268 0.0999
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0093 0.0346
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0093 0.0096
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Trichomonas vaginalis tubulin epsilon chain, putative 0.019 0.1111 0.4114
Loa Loa (eye worm) tubulin alpha 2 0.0057 0.0264 0.0984
Brugia malayi hypothetical protein 0.0064 0.0309 0.1149
Trichomonas vaginalis aldo/keto reductase, putative 0.0436 0.2685 1
Echinococcus multilocularis microtubule associated protein 2 0.068 0.4241 0.4241
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0000043503 0.0000045081
Plasmodium falciparum tubulin delta chain, putative 0.0058 0.0269 0.1904
Schistosoma mansoni biogenic amine receptor 0.0064 0.0309 0.032
Schistosoma mansoni amine GPCR 0.0064 0.0309 0.032
Trichomonas vaginalis tubulin alpha chain, putative 0.0075 0.038 0.1383
Echinococcus granulosus allatostatin A receptor 0.0064 0.0309 0.0443
Schistosoma mansoni biogenic amine receptor 0.0064 0.0309 0.032
Trypanosoma brucei aldo-keto reductase, putative 0.0436 0.2685 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0132 0.0743 0.274
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0038 0.0054
Schistosoma mansoni tubulin subunit beta 0.0237 0.1412 0.1464
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0093 0.0346
Echinococcus multilocularis fmrfamide receptor 0.0064 0.0309 0.0309
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0064 0.0309 0.0309
Onchocerca volvulus 0.0064 0.0309 0.0841
Echinococcus multilocularis ATP binding cassette sub family G 0.0039 0.0151 0.0151
Trichomonas vaginalis tubulin beta chain, putative 0.0237 0.1412 0.5241
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus granulosus neuropeptide receptor 0.0064 0.0309 0.0443
Plasmodium vivax delta tubulin, putative 0.0058 0.0269 0.1904
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0058 0.0269 1
Entamoeba histolytica tubulin family protein 0.0237 0.1412 0.5218
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0023 0.0034
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Schistosoma mansoni tubulin subunit gamma 0.0133 0.0748 0.0775
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.0309 0.1149
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0123 0.0128
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.0309 0.0443
Giardia lamblia Aldose reductase 0.0436 0.2685 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0346
Trypanosoma brucei beta tubulin 0.0237 0.1412 0.5259
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Schistosoma mansoni loxhd1 0.0038 0.0147 0.0152
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0123 0.0177
Trypanosoma cruzi tubulin gamma chain 0.0133 0.0748 0.2784
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0023
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0058 0.0269 0.1001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0245 0.1462 0.5444
Loa Loa (eye worm) hypothetical protein 0.0132 0.0743 0.2766
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0105 0.0392
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0038 0.0141
Echinococcus granulosus tubulin alpha 1C chain 0.019 0.1111 0.1595
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0424 0.044
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0126 0.0708 0.1016
Schistosoma mansoni tubulin subunit epsilon 0.0133 0.0748 0.0775
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0093 0.0346
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0064 0.0309 0.0309
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.0309 0.1149
Brugia malayi beta-tubulin, identical 0.0237 0.1412 0.5256
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.0309 0.0443
Giardia lamblia Beta tubulin 0.0237 0.1412 0.5218
Leishmania major alpha tubulin 0.019 0.1111 0.4136
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0093 0.0096
Trichomonas vaginalis aldo-keto reductase, putative 0.0436 0.2685 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0038 0.0141
Echinococcus granulosus phd:f box containing protein 0.0015 0.0000043503 0.0000062456
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0093 0.0096
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Schistosoma mansoni lipoxygenase 0.0161 0.0928 0.0962
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0312 0.1163
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0271 0.0281
Trypanosoma cruzi tubulin delta chain 0.0058 0.0269 0.1001
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0229 0.0853
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0778 0.0806
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0004 0.0017
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0038 0.0054
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0245 0.1462 0.2099
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0436 0.2685 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0312 0.1163
Schistosoma mansoni potassium channel beta 0.0126 0.0708 0.0733
Echinococcus multilocularis tubulin alpha 3 chain 0.019 0.1111 0.1111
Schistosoma mansoni hypothetical protein 0.0064 0.0309 0.032
Trichomonas vaginalis tubulin epsilon chain, putative 0.0237 0.1412 0.5241
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0093 0.001
Plasmodium falciparum alpha tubulin 2 0.019 0.1111 0.7865
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0064 0.0309 0.0309
Plasmodium falciparum alpha tubulin 1 0.019 0.1111 0.7865
Echinococcus granulosus hypothetical protein 0.0436 0.2685 0.3855
Brugia malayi hypothetical protein 0.0035 0.0123 0.0458
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Trichomonas vaginalis chromobox protein, putative 0.0041 0.016 0.0561
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0424 0.1579
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus granulosus tubulin gamma 1 chain 0.0133 0.0748 0.1073
Brugia malayi chromobox protein homolog 3 0.0038 0.0142 0.0529
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0309 0.0309
Trichomonas vaginalis tubulin beta chain, putative 0.019 0.1111 0.4114
Entamoeba histolytica alcohol dehydrogenase, putative 0.0126 0.0708 0.2571
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Brugia malayi G protein-coupled receptor F59B2.13 0.0064 0.0309 0.1149
Onchocerca volvulus Neuropeptide F receptor homolog 0.0064 0.0309 0.0841
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0093 0.0346
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0346
Schistosoma mansoni hypothetical protein 0.0064 0.0309 0.032
Schistosoma mansoni rab6-interacting 0.0038 0.0147 0.0152
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.0309 0.0443
Brugia malayi sulfakinin receptor protein 0.0064 0.0309 0.1149
Trichomonas vaginalis aldo-keto reductase, putative 0.0436 0.2685 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0038 0.0141
Trichomonas vaginalis aldo-keto reductase, putative 0.0126 0.0708 0.2608
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0038 0.0054
Mycobacterium leprae Conserved hypothetical protein 0.031 0.1879 0.6954
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0038 0.0054
Schistosoma mansoni smad 0.0016 0.0004 0.0005
Echinococcus granulosus alpha tubulin 0.019 0.1111 0.1595
Trichomonas vaginalis tubulin beta chain, putative 0.019 0.1111 0.4114
Loa Loa (eye worm) Smad1 0.0016 0.0004 0.0017
Echinococcus multilocularis tubulin alpha chain 0.019 0.1111 0.1111
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0048 0.0343
Echinococcus multilocularis orexin receptor type 2 0.0064 0.0309 0.0309
Loa Loa (eye worm) tubulin gamma chain 0.0133 0.0748 0.2783
Echinococcus granulosus Tubulin beta 2C chain 0.0237 0.1412 0.2028
Trypanosoma brucei aldo/keto reductase, putative 0.0126 0.0708 0.2636
Onchocerca volvulus 0.0436 0.2685 0.9994
Trichomonas vaginalis chromobox protein, putative 0.0041 0.016 0.0561
Echinococcus granulosus neuropeptide s receptor 0.0064 0.0309 0.0443
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0229 0.0818
Schistosoma mansoni tubulin subunit beta 0.0237 0.1412 0.1464
Echinococcus granulosus ATP binding cassette sub family G 0.0039 0.0151 0.0216
Loa Loa (eye worm) hypothetical protein 0.0082 0.0424 0.1579
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0309 0.032
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0436 0.2685 0.9994
Echinococcus multilocularis Tubulin alpha 1 chain 0.019 0.1111 0.1111
Loa Loa (eye worm) tubulin alpha-2 chain 0.019 0.1111 0.4134
Echinococcus granulosus tubulin beta 1 chain 0.0237 0.1412 0.2028
Brugia malayi alpha-tubulin 0.019 0.1111 0.4134
Echinococcus multilocularis muscleblind protein 0.0144 0.0822 0.0822
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0309 0.032
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0004 0.0004
Echinococcus multilocularis neuropeptide receptor 0.0064 0.0309 0.0309
Onchocerca volvulus 0.0437 0.2687 1
Giardia lamblia Gamma tubulin 0.0133 0.0748 0.2721
Onchocerca volvulus 0.0064 0.0309 0.0841
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0436 0.2685 0.3855
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0093 0.0346
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0038 0.0054
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0017
Schistosoma mansoni tubulin subunit beta 0.0237 0.1412 0.1464
Schistosoma mansoni cpg binding protein 0.0061 0.0289 0.03
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0093 0.0346
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0023 0.0087
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0229 0.0773
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0309 0.0309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0245 0.1462 0.5403
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0309 0.0309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0778 0.0806
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0093 0.0096
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0048 0.102
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.0718 0.1031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0123 0.0123
Schistosoma mansoni tubulin subunit beta 0.0058 0.0269 0.0279
Trypanosoma cruzi epsilon tubulin, putative 0.0133 0.0748 0.2784
Schistosoma mansoni tubulin subunit delta 0.0058 0.0269 0.0279
Echinococcus multilocularis muscleblind protein 1 0.0144 0.0822 0.0822
Toxoplasma gondii beta-tubulin, putative 0.0237 0.1412 0.5259
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0332 0.1235
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.965 1
Leishmania major alpha tubulin 0.019 0.1111 0.4136
Entamoeba histolytica tubulin alpha-1 chain 0.019 0.1111 0.4085
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0309 0.0443
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0038 0.0141
Trypanosoma brucei epsilon tubulin 0.0133 0.0748 0.2784
Giardia lamblia Alpha-tubulin 0.019 0.1111 0.4085
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0048 0.102
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0229 0.0818
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Toxoplasma gondii aldose reductase, putative 0.0436 0.2685 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0064 0.0309 0.032
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0064 0.0309 0.032
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 0.1412 0.1412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0309 0.0309
Echinococcus granulosus hypothetical protein 0.0064 0.0309 0.0443
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0436 0.2685 0.3855
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0309 0.032
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0023 0.0166
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0004 0.0004
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0038 0.0141
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0038 0.0054
Brugia malayi Melatonin receptor type 1A 0.0064 0.0309 0.1149
Brugia malayi MH2 domain containing protein 0.0237 0.1414 0.5263
Echinococcus multilocularis sex peptide receptor 0.0064 0.0309 0.0309
Loa Loa (eye worm) oxidoreductase 0.0436 0.2685 0.9994
Trichomonas vaginalis tubulin alpha chain, putative 0.0075 0.038 0.1383
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0064 0.0309 0.1149
Schistosoma mansoni tubulin subunit alpha 0.019 0.1111 0.1151
Loa Loa (eye worm) TYRA-2 protein 0.0064 0.0309 0.1149
Trichomonas vaginalis aldo-keto reductase, putative 0.0436 0.2685 1
Trypanosoma brucei tubulin delta chain 0.0058 0.0269 0.1001
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0105 0.0392
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0048 0.018
Brugia malayi nuclear receptor RXR 0.0016 0.0003 0.0009
Echinococcus multilocularis beta tubulin 0.0237 0.1412 0.1412
Brugia malayi Muscleblind-like protein 0.0144 0.0822 0.306
Loa Loa (eye worm) tubulin beta-4 chain 0.0237 0.1412 0.5256
Schistosoma mansoni neuropeptide receptor 0.0064 0.0309 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0309 0.032
Loa Loa (eye worm) tubulin beta chain 0.0237 0.1412 0.5256
Schistosoma mansoni neuropeptide receptor 0.0064 0.0309 0.032
Entamoeba histolytica tubulin family protein 0.0237 0.1412 0.5218
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0093 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0309 0.032
Loa Loa (eye worm) hypothetical protein 0.0437 0.2687 1
Plasmodium falciparum LCCL domain-containing protein 0.0038 0.0147 0.1041
Loa Loa (eye worm) hypothetical protein 0.0038 0.0147 0.0547
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0436 0.2685 0.2685
Giardia lamblia Beta tubulin 0.0237 0.1412 0.5218
Trichomonas vaginalis tubulin gamma chain, putative 0.0058 0.0269 0.0967
Echinococcus granulosus arachidonate 5 lipoxygenase 0.023 0.137 0.1967
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0269 0.0967
Trypanosoma brucei prostaglandin f synthase 0.0436 0.2685 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0436 0.2685 1
Trypanosoma brucei alpha tubulin 0.019 0.1111 0.4136
Mycobacterium ulcerans oxidoreductase 0.0436 0.2685 1
Echinococcus multilocularis dnaJ subfamily B 0.0819 0.5128 0.5128
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0039 0.0151 0.0478
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0093 0.0093
Echinococcus multilocularis aldehyde reductase 0.031 0.1879 0.1879
Brugia malayi larval opioid receptor 0.0064 0.0309 0.1149
Giardia lamblia Beta tubulin 0.0237 0.1412 0.5218
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0003 0.0003
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0436 0.2685 0.2685
Onchocerca volvulus 0.0064 0.0309 0.0841
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0424 0.0609
Schistosoma mansoni thyroid hormone receptor 0.0158 0.091 0.0943
Schistosoma mansoni histamine h1 receptor 0.0064 0.0309 0.032
Entamoeba histolytica tubulin gamma chain 0.0133 0.0748 0.2721
Echinococcus multilocularis serotonin receptor 0.0064 0.0309 0.0309
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0093 0.0096
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0038 0.0141
Echinococcus granulosus Tubulin beta 2C chain 0.0237 0.1412 0.2028
Loa Loa (eye worm) hypothetical protein 0.003 0.009 0.0335
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0436 0.2685 0.2685
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0229 0.0853
Loa Loa (eye worm) tubulin alpha chain 0.019 0.1111 0.4134
Schistosoma mansoni hypothetical protein 0.0033 0.0109 0.0113
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0436 0.2685 1
Echinococcus multilocularis ATP binding cassette sub family G 0.0039 0.0151 0.0151
Echinococcus granulosus aldo keto reductase 0.0436 0.2685 0.3855
Echinococcus multilocularis tubulin alpha 3 chain 0.019 0.1111 0.1111
Brugia malayi RNA binding protein 0.0064 0.0312 0.1163
Leishmania major epsilon tubulin, putative 0.0133 0.0748 0.2784
Mycobacterium tuberculosis Probable oxidoreductase 0.0436 0.2685 1
Echinococcus multilocularis allatostatin A receptor 0.0064 0.0309 0.0309
Echinococcus granulosus tubulin alpha 1C chain 0.019 0.1111 0.1595
Brugia malayi Tubulin alpha chain 0.019 0.1111 0.4134
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0199 0.0199
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.0309 0.0309
Trichomonas vaginalis tubulin alpha chain, putative 0.0133 0.0748 0.2757
Trichomonas vaginalis aldo-keto reductase, putative 0.0126 0.0708 0.2608
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0015 0.0015
Echinococcus granulosus tubulin alpha 0.0133 0.0748 0.1073
Brugia malayi cytochrome P450 0.0021 0.0038 0.014
Loa Loa (eye worm) hypothetical protein 0.019 0.1111 0.4134
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0064 0.0309 0.1149
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.0309 0.0443
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0292 0.042
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.0718 0.0718
Echinococcus granulosus cpg binding protein 0.0061 0.0289 0.0415
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0038 0.0141
Schistosoma mansoni amine GPCR 0.0064 0.0309 0.032
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0055 0.0167
Schistosoma mansoni Smad4 0.0016 0.0004 0.0005
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.0309 0.0309
Brugia malayi Cytochrome P450 family protein 0.0032 0.0105 0.0392
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0093 0.0096
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Brugia malayi tubulin alpha chain - mouse 0.019 0.1111 0.4134
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Trichomonas vaginalis tubulin beta chain, putative 0.0075 0.038 0.1383
Schistosoma mansoni polycystin 1-related 0.0038 0.0147 0.0152
Echinococcus granulosus orexin receptor type 2 0.0064 0.0309 0.0443
Echinococcus granulosus neuropeptide receptor A26 0.0064 0.0309 0.0443
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 0.1412 0.1412
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.0309 0.0309
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0013 0.005
Echinococcus multilocularis somatostatin receptor 0.0064 0.0309 0.0309
Echinococcus multilocularis tubulin alpha chain 0.019 0.1111 0.1111
Leishmania major alpha tubulin 0.019 0.1111 0.4136
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0843 0.3138
Trichomonas vaginalis aldo-keto reductase, putative 0.0436 0.2685 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0114 0.0632 0.2352
Toxoplasma gondii beta-1 tubulin, putative 0.0237 0.1412 0.5259
Echinococcus multilocularis dro:myosuppressin receptor 0.0064 0.0309 0.0309
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0309 0.0309
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0436 0.2685 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0064 0.0309 0.032
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0005
Echinococcus multilocularis tubulin alpha 1C chain 0.019 0.1111 0.1111
Leishmania major cytochrome p450-like protein 0.0021 0.0038 0.0141
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0436 0.2685 0.3855
Echinococcus granulosus tubulin alpha chain 0.019 0.1111 0.1595
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0004 0.0017
Echinococcus multilocularis Smad4 0.0016 0.0004 0.0004
Echinococcus multilocularis GPCR, family 2 0.0047 0.0199 0.0199
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0312 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0093 0.0346
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0207
Echinococcus multilocularis tubulin alpha 0.0133 0.0748 0.0748
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0038 0.0141
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0004 0.0006
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0064 0.0309 0.032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0003 0.0003
Echinococcus granulosus fmrfamide receptor 0.0064 0.0309 0.0443
Loa Loa (eye worm) oxidoreductase 0.0436 0.2685 0.9994
Loa Loa (eye worm) tubulin alpha 2 0.0132 0.0743 0.2766
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0778 0.1117
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0055 0.0167
Trypanosoma brucei protein kinase, putative 0.0051 0.0229 0.0853
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0055 0.0167
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0309 0.0443
Onchocerca volvulus 0.0064 0.0309 0.0841
Schistosoma mansoni hypothetical protein 0.0035 0.0123 0.0128
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Trypanosoma cruzi alpha tubulin, putative 0.019 0.1111 0.4136
Leishmania major alpha tubulin 0.019 0.1111 0.4136
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0436 0.2685 1
Brugia malayi Dopamine receptor 0.0064 0.0309 0.1149
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0093 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0269 0.0967
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0064 0.0236
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0038 0.0054
Schistosoma mansoni tubulin subunit beta 0.0237 0.1412 0.1464
Brugia malayi putative neuropeptide receptor NPR1 0.0064 0.0309 0.1149
Echinococcus granulosus aldo keto reductase 0.0436 0.2685 0.3855
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0331 0.1199
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0058 0.0269 0.0967
Loa Loa (eye worm) tubulin beta-2A chain 0.0237 0.1412 0.5256
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0038 0.0054
Echinococcus multilocularis neuropeptide s receptor 0.0064 0.0309 0.0309
Brugia malayi hypothetical protein 0.0064 0.0309 0.1149
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.0245 0.1462 0.1515
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0093 0.0133
Echinococcus multilocularis neuropeptide receptor A26 0.0064 0.0309 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0142 0.0493
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0309 0.032
Echinococcus granulosus Tubulin beta 2C chain 0.0237 0.1412 0.2028
Brugia malayi hypothetical protein 0.0016 0.0003 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0093 0.0346
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0147 0.0211
Echinococcus granulosus tubulin alpha chain 0.019 0.1111 0.1595
Schistosoma mansoni lozenge 0.0055 0.0251 0.026
Trypanosoma brucei epsilon tubulin 0.0133 0.0748 0.2784
Brugia malayi NADH-dependent xylose reductase 0.0126 0.0708 0.2634
Schistosoma mansoni ABC transporter 0.0033 0.0113 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0309 0.0309
Echinococcus multilocularis serotonin receptor 0.0064 0.0309 0.0309
Trichomonas vaginalis tubulin beta chain, putative 0.019 0.1111 0.4114
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0331 0.1231
Trypanosoma cruzi zeta tubulin, putative 0.0058 0.0269 0.1001
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus multilocularis tubulin subunit TubB 0.019 0.1111 0.1111
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Schistosoma mansoni aldehyde dehydrogenase 0.0245 0.1462 0.1515
Brugia malayi Tubulin alpha-2 chain 0.019 0.1111 0.4134
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Plasmodium vivax tubulin alpha chain, putative 0.019 0.1111 0.7865
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0093 0.0133
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0093 0.0133
Onchocerca volvulus 0.0058 0.0268 0.0686
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0436 0.2685 0.2685
Echinococcus multilocularis geminin 0.0166 0.0959 0.0959
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0312 0.1163
Brugia malayi TAR-binding protein 0.0064 0.0312 0.1163
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0436 0.2685 0.2685
Loa Loa (eye worm) hypothetical protein 0.0148 0.0843 0.3138
Echinococcus granulosus g protein coupled receptor 0.0064 0.0309 0.0443
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Loa Loa (eye worm) tubulin beta-1 chain 0.0237 0.1412 0.5256
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0229 0.0229
Plasmodium vivax ABC transporter G family member 2, putative 0.0039 0.0151 0.1066
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0093 0.0346
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0199 0.0286
Brugia malayi G-protein coupled receptor 0.0064 0.0309 0.1149
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.0309 0.0443
Brugia malayi hypothetical protein 0.0437 0.2687 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0312 0.0312
Leishmania major alpha tubulin 0.019 0.1111 0.4136
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0000043503 0.0000045081
Loa Loa (eye worm) hypothetical protein 0.0144 0.0822 0.306
Onchocerca volvulus 0.0064 0.0309 0.0841
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.023 0.137 0.137
Schistosoma mansoni thyroid hormone receptor 0.0158 0.091 0.0943
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0229 0.0818
Echinococcus granulosus G protein coupled receptor 139 0.0064 0.0309 0.0443
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0064 0.0309 0.0443
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0038 0.0054
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0126 0.0708 0.2636
Giardia lamblia Delta tubulin 0.0058 0.0269 0.0922
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0331 0.1199
Echinococcus granulosus tubulin alpha chain 0.019 0.1111 0.1595
Trypanosoma brucei epsilon tubulin 0.0133 0.0748 0.2784
Echinococcus granulosus serotonin receptor 0.0064 0.0309 0.0443
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0038 0.0141
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0292 0.0303
Brugia malayi Doublecortin family protein 0.0038 0.0147 0.0547
Leishmania major alpha tubulin 0.019 0.1111 0.4136
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0038 0.0141
Loa Loa (eye worm) hypothetical protein 0.0436 0.2685 0.9994
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0778 0.1117
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0064 0.0309 0.1149
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0064 0.0309 0.0443
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0271 0.0389
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0064 0.0309 0.1149
Echinococcus granulosus tm gpcr rhodopsin 0.1107 0.6965 1
Echinococcus multilocularis RUN 0.0038 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0126 0.0708 0.2634
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0055 0.0167
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0436 0.2685 0.2685
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0000043503 0.0000045081
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0023 0.0087
Schistosoma mansoni amine GPCR 0.0064 0.0309 0.032
Echinococcus granulosus g protein coupled receptor 0.0064 0.0309 0.0443
Trypanosoma brucei alpha tubulin 0.019 0.1111 0.4136
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0000043503 0.0000062456
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.0309 0.032
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Schistosoma mansoni amine GPCR 0.0064 0.0309 0.032
Brugia malayi ORL1-like opioid receptor 0.0064 0.0309 0.1149
Loa Loa (eye worm) tubulin beta chain 0.0058 0.0269 0.1001
Brugia malayi Tubulin alpha-2 chain 0.019 0.1111 0.4134
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0093 0.0096
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0005
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Schistosoma mansoni neuropeptide receptor 0.0064 0.0309 0.032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0245 0.1462 0.5403
Entamoeba histolytica hypothetical protein 0.0035 0.0123 0.0375
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0114 0.0632 0.2324
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0199 0.0742
Trichomonas vaginalis tubulin epsilon chain, putative 0.019 0.1111 0.4114
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0064 0.0309 0.0309
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0038 0.0054
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0292 0.1087
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0038 0.0054
Echinococcus multilocularis 0.0021 0.0038 0.0038
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 0.1412 0.1412
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0229 0.0229
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0038 0.0141
Trichomonas vaginalis tubulin beta chain, putative 0.019 0.1111 0.4114
Loa Loa (eye worm) BEN-1 protein 0.0237 0.1412 0.5256
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0039 0.0151 0.0156
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0000043503 0.0000043503
Brugia malayi Serotonin receptor 0.0064 0.0309 0.1149
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.0309 0.0443
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.0309 0.0443
Onchocerca volvulus 0.0064 0.0309 0.0841
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0038 0.0054
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0229 0.0329
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0778 0.2895
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0436 0.2685 0.3855
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0126 0.0708 0.2636
Loa Loa (eye worm) tubulin alpha 2 0.0132 0.0743 0.2766
Echinococcus multilocularis aldo keto reductase 0.0436 0.2685 0.2685
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0017
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0778 0.0778
Schistosoma mansoni lipoxygenase 0.023 0.137 0.142
Echinococcus multilocularis tubulin subunit beta 0.0237 0.1412 0.1412
Trichomonas vaginalis tubulin, putative 0.0237 0.1412 0.5241
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0048 0.0094
Trypanosoma brucei zeta tubulin 0.0058 0.0269 0.1001
Brugia malayi hypothetical protein 0.0025 0.0064 0.0236
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0003 0.0009
Treponema pallidum cell division protein FtsZ 0.0058 0.0269 1
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0093 0.0093
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0000043503 0.0000043503
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0064 0.0309 0.0309
Schistosoma mansoni aldo-keto reductase 0.0436 0.2685 0.2783
Brugia malayi Tubulin gamma chain 0.0133 0.0748 0.2783
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0093 0.0346
Leishmania major alpha tubulin 0.019 0.1111 0.4136
Plasmodium vivax tubulin beta chain, putative 0.0237 0.1412 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0142 0.0493
Echinococcus granulosus tubulin epsilon chain 0.0133 0.0748 0.1073
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0229 0.0853
Trypanosoma brucei beta tubulin 0.0237 0.1412 0.5259
Onchocerca volvulus 0.0436 0.2685 0.9994
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0843 0.3138
Echinococcus multilocularis smad 0.0016 0.0004 0.0004
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0015 0.0056
Echinococcus granulosus tubulin subunit beta 0.0237 0.1412 0.2028
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0093 0.0346
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0346
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0039 0.0151 0.0561
Loa Loa (eye worm) beta-tubulin 0.0237 0.1412 0.5256
Schistosoma mansoni opsin-like receptor 0.0064 0.0309 0.032
Schistosoma mansoni tubulin subunit beta 0.0237 0.1412 0.1464
Onchocerca volvulus 0.0064 0.0309 0.0841
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0424 0.0424
Onchocerca volvulus 0.0064 0.0309 0.0841
Schistosoma mansoni growth hormone secretagogue receptor 0.0064 0.0309 0.032
Schistosoma mansoni tubulin subunit beta 0.0237 0.1412 0.1464
Trichomonas vaginalis tubulin beta chain, putative 0.019 0.1111 0.4114
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0436 0.2685 0.3855
Schistosoma mansoni amine GPCR 0.0064 0.0309 0.032
Onchocerca volvulus 0.0064 0.0309 0.0841
Brugia malayi hypothetical protein 0.0064 0.0309 0.1149
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0093 0.0093
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0033 0.0109 0.0407
Brugia malayi hypothetical protein 0.0064 0.0309 0.1149
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0023 0.0087
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0038 0.0141
Brugia malayi Cell division protein ftsZ 0.0058 0.0269 0.1001
Schistosoma mansoni hypothetical protein 0.0101 0.0545 0.0565
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0309 0.0443
Schistosoma mansoni hypothetical protein 0.0819 0.5128 0.5314
Loa Loa (eye worm) runx1 0.0055 0.0251 0.0934
Trichomonas vaginalis aldo-keto reductase, putative 0.0436 0.2685 1
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0024
Onchocerca volvulus 0.0064 0.0309 0.0841
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0038 0.0141
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0309 0.0443
Schistosoma mansoni coup transcription factor 0.003 0.0093 0.0096
Trichomonas vaginalis tubulin epsilon chain, putative 0.0237 0.1412 0.5241
Echinococcus granulosus tachykinin peptides receptor 99D 0.0064 0.0309 0.0443
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0048 0.004
Echinococcus multilocularis Tubulin alpha 1 chain 0.019 0.1111 0.1111
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0038 0.0141
Loa Loa (eye worm) RNA binding protein 0.0064 0.0312 0.1163
Mycobacterium tuberculosis Conserved protein 0.0126 0.0708 0.2636
Trypanosoma cruzi zeta tubulin, putative 0.0058 0.0269 0.1001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.0309 0.032
Echinococcus granulosus chromobox protein 1 0.0067 0.0331 0.0475
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0093 0.0133
Echinococcus granulosus g-protein coupled receptor 0.0064 0.0309 0.0443
Trichomonas vaginalis aldo-keto reductase, putative 0.0436 0.2685 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0064 0.0309 0.1149
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0048 0.018
Brugia malayi nuclear receptor NHR-88 0.003 0.0093 0.0346
Leishmania major hypothetical protein, conserved 0.0025 0.0064 0.0236
Giardia lamblia ABC transporter 0.0038 0.0147 0.0464
Echinococcus granulosus tubulin alpha chain 0.019 0.1111 0.1595
Loa Loa (eye worm) hypothetical protein 0.0114 0.0632 0.2352
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0093 0.0133
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0015 0.0021
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 0.1412 0.1412
Brugia malayi MAP kinase sur-1 0.0051 0.0229 0.0853
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.0309 0.1149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0093 0.0346
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0075 0.038 0.1383
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0064 0.0236
Echinococcus granulosus somatostatin receptor 0.0064 0.0309 0.0443
Brugia malayi hypothetical protein 0.0016 0.0003 0.0009
Mycobacterium ulcerans cell division protein FtsZ 0.0058 0.0269 0.0922
Echinococcus multilocularis peroxisome assembly protein 26 0.019 0.1111 0.1111
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus granulosus Tubulin alpha 1 chain 0.019 0.1111 0.1595
Brugia malayi hypothetical protein 0.0064 0.0309 0.1149
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0199 0.0286
Loa Loa (eye worm) hypothetical protein 0.0047 0.0199 0.0742
Echinococcus granulosus tubulin alpha 3 chain 0.019 0.1111 0.1595
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0064 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0144 0.0822 0.306
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0093 0.0346
Echinococcus granulosus Tubulin alpha 1 chain 0.019 0.1111 0.1595
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0093 0.0346
Plasmodium falciparum ABC transporter G family member 2 0.0039 0.0151 0.1066
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Brugia malayi ABC transporter family protein 0.0033 0.0113 0.042
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0000043503 0.0000043503
Schistosoma mansoni hypothetical protein 0.0021 0.0038 0.0039
Trypanosoma cruzi beta tubulin, putative 0.0237 0.1412 0.5259
Brugia malayi GnHR receptor homolog 0.0064 0.0309 0.1149
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0038 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0072 0.023
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0023 0.0087
Echinococcus multilocularis fmrfamide receptor 0.0064 0.0309 0.0309
Echinococcus granulosus aldo keto reductase 0.0436 0.2685 0.3855
Echinococcus granulosus dnaJ subfamily B 0.0819 0.5128 0.7362
Toxoplasma gondii alpha tubulin TUBA1 0.019 0.1111 0.4136
Trichomonas vaginalis tubulin, putative 0.0075 0.038 0.1383
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0105 0.0392
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0064 0.0309 0.1149
Plasmodium falciparum tubulin gamma chain 0.0133 0.0748 0.5294
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0003 0.0009
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0058 0.0269 0.1001
Echinococcus multilocularis tubulin alpha chain 0.019 0.1111 0.1111
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0039 0.0151 0.0478
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0000043503 0.0000062456
Schistosoma mansoni opsin-like receptor 0.0064 0.0309 0.032
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.0309 0.1149
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0292 0.0303
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0064 0.0309 0.1149
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0038 0.0141
Echinococcus granulosus geminin 0.0166 0.0959 0.1377
Echinococcus granulosus neuropeptide FF receptor 2 0.0064 0.0309 0.0443
Trichomonas vaginalis aldo-keto reductase, putative 0.0436 0.2685 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0126 0.0708 0.2571
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0309 0.0309
Brugia malayi neuropeptide F receptor 0.0064 0.0309 0.1149
Leishmania major alpha tubulin 0.019 0.1111 0.4136
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0436 0.2685 0.9994
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0093 0.0346
Echinococcus granulosus alpha 1A adrenergic receptor 0.0064 0.0309 0.0443
Plasmodium vivax aldehyde reductase, putative 0.0126 0.0708 0.5011
Echinococcus multilocularis g-protein coupled receptor 0.0064 0.0309 0.0309
Echinococcus granulosus Tubulin beta 2C chain 0.0237 0.1412 0.2028
Onchocerca volvulus 0.0064 0.0309 0.0841
Echinococcus granulosus neuropeptide receptor 0.0064 0.0309 0.0443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0093 0.0346
Toxoplasma gondii alpha-tubulin I, putative 0.019 0.1111 0.4136
Plasmodium falciparum aldehyde reductase, putative 0.0126 0.0708 0.5011
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0049
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0039 0.0151 0.0561
Loa Loa (eye worm) doublecortin family protein 0.0038 0.0147 0.0547
Echinococcus granulosus RUN 0.0038 0.0147 0.0211
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0064 0.045
Echinococcus granulosus Smad4 0.0016 0.0004 0.0006
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0245 0.1462 0.5444
Toxoplasma gondii beta tubulin 0.0237 0.1412 0.5259
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0038 0.0141
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0064 0.0309 0.1149
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0048 0.018
Brugia malayi steroid hormone receptor 0.003 0.0093 0.0346
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0021 0.0021
Schistosoma mansoni nuclear hormone receptor 0.003 0.0093 0.0096
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0038 0.0054
Echinococcus granulosus 7TM GPCR rhodopsin 0.0064 0.0309 0.0443
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0093 0.0093
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0048 0.0094
Entamoeba histolytica aldose reductase, putative 0.0436 0.2685 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0147 0.0211
Schistosoma mansoni alpha tubulin 0.019 0.1111 0.1151
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0436 0.2685 0.2685
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0093 0.0346
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0346
Brugia malayi Cytochrome P450 family protein 0.0032 0.0105 0.0392
Echinococcus multilocularis tubulin alpha chain 0.019 0.1111 0.1111
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0038 0.0054
Entamoeba histolytica hypothetical protein 0.0035 0.0123 0.0375
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0038 0.0054
Entamoeba histolytica aldose reductase, putative 0.0436 0.2685 1
Echinococcus granulosus beta tubulin 0.0237 0.1412 0.2028
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0309 0.0443
Echinococcus granulosus microtubule associated protein 2 0.068 0.4241 0.6089
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.0309 0.0309
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0312 0.0324
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0133 0.0748 0.2784
Brugia malayi putative neuropeptide receptor 0.0064 0.0309 0.1149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Leishmania major gamma-tubulin 0.0133 0.0748 0.2784
Echinococcus multilocularis beta tubulin 0.0237 0.1412 0.1412
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0048 0.0343
Schistosoma mansoni hypothetical protein 0.0128 0.0718 0.0744
Echinococcus granulosus tubulin alpha 3 chain 0.019 0.1111 0.1595
Echinococcus multilocularis tubulin gamma 1 chain 0.0133 0.0748 0.0748
Leishmania major cytochrome p450-like protein 0.0032 0.0105 0.0392
Entamoeba histolytica ABC transporter, putative 0.0039 0.0151 0.0478
Mycobacterium ulcerans aldehyde dehydrogenase 0.0245 0.1462 0.5403
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0009
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0064 0.0309 0.032
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0038 0.0054
Brugia malayi neuropeptide F receptor 0.0064 0.0309 0.1149
Brugia malayi Tubulin beta-1 chain 0.0237 0.1412 0.5256
Brugia malayi Smad1 0.0016 0.0004 0.0017
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0038 0.0054
Onchocerca volvulus 0.0064 0.0309 0.0841
Schistosoma mansoni alpha-1 adrenergic receptor 0.0064 0.0309 0.032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0778 0.2895
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0229 0.0853
Mycobacterium ulcerans hypothetical protein 0.0126 0.0708 0.2571
Schistosoma mansoni myosin xvIII 0.0064 0.0309 0.032
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0048 0.018
Entamoeba histolytica hypothetical protein 0.0035 0.0123 0.0375
Trichomonas vaginalis aldo-keto reductase, putative 0.0436 0.2685 1
Schistosoma mansoni alpha tubulin 0.019 0.1111 0.1151
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus granulosus Polycystic kidney disease protein 0.0038 0.0147 0.0211
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0093 0.0133
Schistosoma mansoni hypothetical protein 0.0064 0.0309 0.032
Leishmania major alpha tubulin 0.019 0.1111 0.4136
Echinococcus multilocularis tubulin beta 1 chain 0.0237 0.1412 0.1412
Brugia malayi hypothetical protein 0.0064 0.0309 0.1149
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0055 0.0167
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0048 0.018
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0142 0.02
Loa Loa (eye worm) cytochrome P450 0.0021 0.0038 0.014
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0229 0.0329
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0105 0.0307
Echinococcus granulosus tubulin alpha chain 0.019 0.1111 0.1595
Plasmodium falciparum tubulin epsilon chain, putative 0.0133 0.0748 0.5294
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.0309 0.032
Brugia malayi Tachykinin-like peptides receptor 99D 0.0064 0.0309 0.1149
Brugia malayi hypothetical protein 0.0038 0.0147 0.0547
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0436 0.2685 0.3855
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0199 0.0742
Echinococcus granulosus peroxisome assembly protein 26 0.019 0.1111 0.1595
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0064 0.0309 0.0309
Plasmodium vivax multidomain scavenger receptor, putative 0.0038 0.0147 0.1041
Echinococcus granulosus muscleblind protein 0.0144 0.0822 0.118
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0237 0.1412 0.1412
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0229 0.0853
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.019 0.1111 0.4114
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Trichomonas vaginalis tubulin gamma chain, putative 0.0133 0.0748 0.2757
Echinococcus multilocularis hypothetical protein 0.019 0.1111 0.1111
Schistosoma mansoni alpha tubulin 0.019 0.1111 0.1151
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0346
Loa Loa (eye worm) alpha-tubulin 0.019 0.1111 0.4134
Trichomonas vaginalis tubulin, putative 0.0075 0.038 0.1383
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0229 0.0853
Trypanosoma brucei beta tubulin 0.0237 0.1412 0.5259
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.1414 0.5263
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Plasmodium falciparum tubulin beta chain 0.0237 0.1412 1
Onchocerca volvulus 0.0126 0.0708 0.2378
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0309 0.0443
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0093 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0072 0.023
Echinococcus multilocularis aldo keto reductase 0.0436 0.2685 0.2685
Echinococcus multilocularis tubulin alpha chain 0.019 0.1111 0.1111
Echinococcus multilocularis aldo keto reductase 0.0436 0.2685 0.2685
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0105 0.0392
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.045
Echinococcus multilocularis Polycystic kidney disease protein 0.0038 0.0147 0.0147
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0049
Brugia malayi Heterochromatin protein 1 0.0067 0.0331 0.1231
Brugia malayi Cytochrome P450 family protein 0.0021 0.0038 0.014
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.0309 0.0443
Onchocerca volvulus 0.0436 0.2685 0.9994
Echinococcus granulosus chromobox protein 1 0.0067 0.0331 0.0475
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1107 0.6965 0.6965
Trypanosoma brucei beta tubulin 0.0133 0.0748 0.2784
Entamoeba histolytica hypothetical protein 0.0023 0.0048 0.0094
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0064 0.0309 0.032
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0199 0.0199
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0436 0.2685 0.9994
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0309 0.032
Brugia malayi jmjC domain containing protein 0.0061 0.0292 0.1087
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0199 0.0742
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.016 0.0271
Echinococcus granulosus GPCR family 2 0.0047 0.0199 0.0286
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.0087
Echinococcus multilocularis G protein coupled receptor 139 0.0064 0.0309 0.0309
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0207
Mycobacterium leprae cell division protein FtsZ 0.0058 0.0269 0.0873
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0064 0.0309 0.0309
Brugia malayi Serotonin receptor 0.0064 0.0309 0.1149
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0003 0.0009
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0271 0.0271
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0000043503 0.0000045081
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0038 0.0054
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0093 0.0133
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0064 0.0309 0.0443
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0055 0.0167
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0093 0.0096
Trichomonas vaginalis aldo/keto reductase, putative 0.0436 0.2685 1
Schistosoma mansoni tubulin subunit alpha 0.019 0.1111 0.1151
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0229 0.0853
Brugia malayi G-protein coupled receptor 0.0064 0.0309 0.1149
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0312 0.0324
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.0309 0.032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0778 0.0806
Onchocerca volvulus 0.0436 0.2685 0.9994
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0436 0.2685 0.2685
Leishmania major alpha tubulin 0.019 0.1111 0.4136
Schistosoma mansoni cpg binding protein 0.0061 0.0289 0.03
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0597 0.2222
Echinococcus granulosus aldehyde reductase 0.031 0.1879 0.2698
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0093 0.0346
Brugia malayi RE15519p 0.0064 0.0309 0.1149
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.0236
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus multilocularis chromobox protein 1 0.0067 0.0331 0.0331
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0000043503 0.0000045081
Brugia malayi G protein-coupled receptor 0.0064 0.0309 0.1149
Echinococcus multilocularis ATP binding cassette sub family G 0.0039 0.0151 0.0151
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0038 0.0141
Echinococcus multilocularis neuropeptide FF receptor 2 0.0064 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.003 0.0093 0.0346
Brugia malayi hypothetical protein 0.0038 0.0147 0.0547
Echinococcus granulosus smad 0.0016 0.0004 0.0006
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0436 0.2685 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Plasmodium vivax tubulin alpha chain, putative 0.019 0.1111 0.7865
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.045
Leishmania major alpha tubulin 0.019 0.1111 0.4136
Entamoeba histolytica aldose reductase, putative 0.0436 0.2685 1
Echinococcus granulosus ATP binding cassette sub family G 0.0039 0.0151 0.0216
Echinococcus multilocularis tubulin alpha 1C chain 0.019 0.1111 0.1111
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0132 0.0743 0.2766
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0436 0.2685 0.2685
Echinococcus granulosus Tubulin beta 2C chain 0.0237 0.1412 0.2028
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0038 0.0141
Echinococcus multilocularis aldo keto reductase 0.0436 0.2685 0.2685
Trypanosoma cruzi ABC transporter, putative 0.0039 0.0151 0.0561
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.0087
Schistosoma mansoni microtubule-associated protein tau 0.068 0.4241 0.4395
Brugia malayi hypothetical protein 0.0064 0.0309 0.1149
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0309 0.0309
Trichomonas vaginalis tubulin alpha chain, putative 0.0237 0.1412 0.5241
Echinococcus granulosus tubulin beta 4A class IVa 0.0237 0.1412 0.2028
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.0309 0.032
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.1674 0.1735
Brugia malayi tubulin alpha-2 chain 0.019 0.1111 0.4134
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0038 0.0141
Entamoeba histolytica hypothetical protein 0.0035 0.0123 0.0375
Brugia malayi hypothetical protein 0.0064 0.0309 0.1149
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0093 0.001
Onchocerca volvulus 0.0436 0.2685 0.9994
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0064 0.0309 0.1149
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 0.1412 0.1412
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0093 0.0096
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Echinococcus granulosus FTZ F1 alpha 0.003 0.0093 0.0133
Plasmodium vivax tubulin epsilon chain, putative 0.0133 0.0748 0.5294
Trypanosoma brucei ATP-binding cassette protein, putative 0.0039 0.0151 0.0561
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0064 0.0309 0.1149
Schistosoma mansoni adenoreceptor 0.0064 0.0309 0.032
Brugia malayi Tubulin beta chain 0.0058 0.0269 0.1001
Brugia malayi Tubulin beta chain 0.0075 0.038 0.1415
Trypanosoma brucei tubulin gamma chain 0.0133 0.0748 0.2784
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0436 0.2685 0.3855
Trichomonas vaginalis aldo-keto reductase, putative 0.0126 0.0708 0.2608
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0126 0.0708 0.2634
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0436 0.2685 0.2685
Echinococcus granulosus sex peptide receptor 0.0064 0.0309 0.0443
Schistosoma mansoni neuropeptide f receptor 76f 0.0064 0.0309 0.032
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0126 0.0708 0.5011
Trypanosoma cruzi tubulin delta chain 0.0058 0.0269 0.1001
Schistosoma mansoni cytochrome P450 0.0021 0.0038 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0038 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0309 0.0443
Echinococcus granulosus beta tubulin 0.0237 0.1412 0.2028
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Trypanosoma brucei alpha tubulin 0.019 0.1111 0.4136
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0064 0.0309 0.032
Schistosoma mansoni hypothetical protein 0.0047 0.0199 0.0207
Loa Loa (eye worm) hypothetical protein 0.0101 0.0545 0.2029
Entamoeba histolytica tubulin alpha chain, putative 0.019 0.1111 0.4085
Trichomonas vaginalis aldo-keto reductase, putative 0.0436 0.2685 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0093 0.0346
Loa Loa (eye worm) hypothetical protein 0.0437 0.2687 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0064 0.0309 0.0443
Trypanosoma cruzi aldo/keto reductase, putative 0.0126 0.0708 0.2636
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0038 0.0054
Echinococcus multilocularis G-protein coupled receptor, putative 0.0064 0.0309 0.0309
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0038 0.0141
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0093 0.0346
Leishmania major aldo-keto reductase-like protein 0.0436 0.2685 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0055 0.0167
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0038 0.0054
Loa Loa (eye worm) oxidoreductase 0.0436 0.2685 0.9994
Onchocerca volvulus 0.003 0.0093 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0093 0.0346
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0309 0.0309
Giardia lamblia Alpha-tubulin 0.019 0.1111 0.4085
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0023 0.0166
Onchocerca volvulus 0.0064 0.0309 0.0841
Trichomonas vaginalis tubulin gamma chain, putative 0.0133 0.0748 0.2757
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0271 0.0271
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0023 0.0087
Mycobacterium tuberculosis Cell division protein FtsZ 0.0058 0.0269 0.1001
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0436 0.2685 0.2685
Loa Loa (eye worm) tubulin alpha chain 0.019 0.1111 0.4134
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0093 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0309 0.0443
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0126 0.0708 0.2636
Loa Loa (eye worm) melatonin receptor type 1A 0.0064 0.0309 0.1149
Leishmania major beta tubulin 0.0237 0.1412 0.5259
Leishmania major zeta tubulin, putative 0.0058 0.0269 0.1001
Trypanosoma brucei beta tubulin 0.0237 0.1412 0.5259
Onchocerca volvulus 0.0064 0.0309 0.0841
Echinococcus granulosus g protein coupled receptor 0.0064 0.0309 0.0443
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0038 0.0141
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0039 0.0151 0.0561
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0003 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0016 0.0023
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0038 0.0141
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0436 0.2685 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0064 0.0309 0.0309
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0126 0.0708 0.2608
Loa Loa (eye worm) oxidoreductase 0.0436 0.2685 0.9994
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0038 0.0141
Onchocerca volvulus 0.0082 0.0424 0.1287
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0003 0.0003
Leishmania major cytochrome p450-like protein 0.0021 0.0038 0.0141
Schistosoma mansoni opsin-like receptor 0.0064 0.0309 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0093 0.0346
Brugia malayi Dopamine receptor protein 1 0.0064 0.0309 0.1149
Schistosoma mansoni tubulin subunit alpha 0.0058 0.0269 0.0279
Trichomonas vaginalis tubulin, putative 0.0058 0.0269 0.0967
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0105 0.0392
Brugia malayi Cytochrome P450 family protein 0.0067 0.0332 0.1235
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Brugia malayi nuclear hormone receptor 0.003 0.0093 0.0346
Echinococcus multilocularis Protein lozenge 0.0055 0.0251 0.0251
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0105 0.0392
Onchocerca volvulus 0.0064 0.0309 0.0841
Brugia malayi jmjC domain containing protein 0.0058 0.0271 0.101
Echinococcus granulosus peptide allatostatin:somatostatin 0.0064 0.0309 0.0443
Schistosoma mansoni hypothetical protein 0.0038 0.0147 0.0152
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0039 0.0151 0.0478
Echinococcus multilocularis chromobox protein 1 0.0067 0.0331 0.0331
Schistosoma mansoni rab6-interacting 0.0038 0.0147 0.0152
Loa Loa (eye worm) hypothetical protein 0.0038 0.0142 0.0529
Loa Loa (eye worm) hypothetical protein 0.0064 0.0309 0.1149
Onchocerca volvulus 0.0064 0.0309 0.0841
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0436 0.2685 0.9994
Echinococcus granulosus ATP binding cassette sub family G 0.0039 0.0151 0.0216
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0000043503 0.0000062456
Echinococcus granulosus dro:myosuppressin receptor 0.0064 0.0309 0.0443
Schistosoma mansoni chromobox protein 0.0067 0.0331 0.0343
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0309 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0708 0.2608
Brugia malayi hypothetical protein 0.0064 0.0309 0.1149
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0004 0.0006
Brugia malayi hypothetical protein 0.0016 0.0006 0.0023
Schistosoma mansoni neuropeptide receptor 0.0064 0.0309 0.032
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0093 0.0093
Leishmania major alpha tubulin 0.019 0.1111 0.4136
Onchocerca volvulus 0.0436 0.2685 0.9994
Loa Loa (eye worm) hypothetical protein 0.0038 0.0147 0.0547
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0545 0.2029
Trichomonas vaginalis aldo-keto reductase, putative 0.0436 0.2685 1
Giardia lamblia Aldose reductase 0.0436 0.2685 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0309 0.0309
Leishmania major prostaglandin f synthase, putative 0.0436 0.2685 1
Onchocerca volvulus 0.0038 0.0147 0.0219
Mycobacterium leprae Possible oxidoreductase 0.0126 0.0708 0.2531
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0309 0.0309

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 15 % Activation of human PXR by cell based luciferase reporter gene assay ChEMBL. 24412072
IC50 (ADMET) = 0.09 uM Inhibition of human CYP3A4-mdiated midazolam 1'-hydroxylase activity ChEMBL. 24412072
IC50 (ADMET) = 0.4 uM Inhibition of human CYP2D6 ChEMBL. 24412072
IC50 (ADMET) = 2.2 uM Inhibition of human CYP2C19 ChEMBL. 24412072
IC50 (ADMET) = 4.7 uM Inhibition of human CYP2C9 ChEMBL. 24412072
IC50 (ADMET) = 15 uM Inhibition of human CYP1A2 ChEMBL. 24412072
IC50 (binding) > 30 uM Inhibition of HIV-1 protease ChEMBL. 24412072

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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