TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 401.544 | Formula: C26H31N3O
H donors: 0 H acceptors: 1 LogP: 6.19 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC(N(C(C)C)CCn1nc(c2c1cccc2)OCc1cccc2c1cccc2)C
InChi: 1S/C26H31N3O/c1-19(2)28(20(3)4)16-17-29-25-15-8-7-14-24(25)26(27-29)30-18-22-12-9-11-21-10-5-6-13-23(21)22/h5-15,19-20H,16-18H2,1-4H3
InChiKey: VPCGQGULMIQIPB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References
Homo sapiens	butyrylcholinesterase	Starlite/ChEMBL	References
Homo sapiens	acetylcholinesterase (Yt blood group)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	acetylcholinesterase 1	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus granulosus	carboxylesterase 5A	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	ko:K01049 acetylcholinesterase [EC3.1.1.7], putative	Get druggable targets OG5_126875	All targets in OG5_126875
Schistosoma japonicum	Acetylcholinesterase 1 precursor, putative	Get druggable targets OG5_126875	All targets in OG5_126875
Brugia malayi	Carboxylesterase family protein	Get druggable targets OG5_126875	All targets in OG5_126875
Echinococcus multilocularis	acetylcholinesterase	Get druggable targets OG5_126875	All targets in OG5_126875
Loa Loa (eye worm)	carboxylesterase	Get druggable targets OG5_126875	All targets in OG5_126875

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Carboxylesterase family protein	butyrylcholinesterase	602 aa	546 aa	30.2 %
Brugia malayi	Carboxylesterase family protein	acetylcholinesterase (Yt blood group)	614 aa	510 aa	26.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0293	0.7949	0.5
Echinococcus multilocularis	tyrosine kinase	0.0293	0.7949	1
Trypanosoma cruzi	protein kinase, putative	0.0293	0.7949	0.5
Schistosoma mansoni	protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0293	0.7949	1
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Loa Loa (eye worm)	TK protein kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0293	0.7949	1
Echinococcus multilocularis	FL cytokine receptor	0.0293	0.7949	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0293	0.7949	0.5
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Trypanosoma brucei	protein kinase, putative	0.0293	0.7949	0.5
Leishmania major	protein kinase, putative	0.0293	0.7949	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0293	0.7949	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0293	0.7949	1
Echinococcus multilocularis	insulin receptor	0.0293	0.7949	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Onchocerca volvulus		0.0293	0.7949	0.5
Schistosoma mansoni	protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TK protein kinase	0.0293	0.7949	1
Onchocerca volvulus		0.0293	0.7949	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0293	0.7949	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0293	0.7949	1
Brugia malayi	protein-tyrosine kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Echinococcus granulosus	tyrosine kinase	0.0293	0.7949	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0293	0.7949	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0293	0.7949	1
Brugia malayi	C-terminal src kinase protein 1	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Echinococcus granulosus	epidermal growth factor receptor	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0293	0.7949	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Trichomonas vaginalis	conserved hypothetical protein	0.0293	0.7949	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0293	0.7949	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Schistosoma mansoni	serine/threonine protein kinase	0.0293	0.7949	1
Plasmodium vivax	protein kinase, putative	0.0293	0.7949	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0293	0.7949	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0293	0.7949	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Brugia malayi	Guanylyl cyclase protein 23	0.0293	0.7949	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TK protein kinase	0.0293	0.7949	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0293	0.7949	1
Schistosoma mansoni	protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0293	0.7949	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Schistosoma mansoni	protein kinase	0.0293	0.7949	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0293	0.7949	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0293	0.7949	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0293	0.7949	1
Schistosoma mansoni	protein kinase	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0293	0.7949	1
Onchocerca volvulus		0.0293	0.7949	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0293	0.7949	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0293	0.7949	1
Schistosoma mansoni	tyrosine protein kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	SRC-1	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Onchocerca volvulus		0.0293	0.7949	0.5
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0293	0.7949	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0293	0.7949	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0293	0.7949	0.5
Echinococcus granulosus	tyrosine kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0293	0.7949	1
Brugia malayi	Raf kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0293	0.7949	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0293	0.7949	1
Schistosoma mansoni	protein kinase	0.0293	0.7949	1
Trypanosoma brucei	Pseudokinase, putative	0.0293	0.7949	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0293	0.7949	1
Echinococcus granulosus	epidermal growth factor receptor	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0293	0.7949	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0293	0.7949	1
Schistosoma mansoni	protein kinase	0.0293	0.7949	1
Echinococcus granulosus	activin receptor type	0.0293	0.7949	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0293	0.7949	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.0293	0.7949	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0293	0.7949	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0293	0.7949	1
Toxoplasma gondii	protein kinase	0.0293	0.7949	0.5
Giardia lamblia	Kinase, NEK	0.0293	0.7949	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0293	0.7949	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0293	0.7949	0.5
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Schistosoma mansoni	protein kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0293	0.7949	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0293	0.7949	1
Onchocerca volvulus		0.0293	0.7949	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0293	0.7949	0.5
Echinococcus multilocularis	protein tyrosine kinase	0.0293	0.7949	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0293	0.7949	1
Leishmania major	protein kinase, putative	0.0293	0.7949	0.5
Schistosoma mansoni	protein kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0293	0.7949	1
Loa Loa (eye worm)	TK protein kinase	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0293	0.7949	1
Trichomonas vaginalis	conserved hypothetical protein	0.0293	0.7949	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0293	0.7949	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Onchocerca volvulus		0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TK protein kinase	0.0293	0.7949	1
Plasmodium falciparum	protein kinase, putative	0.0293	0.7949	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0293	0.7949	1
Trypanosoma cruzi	protein kinase, putative	0.0293	0.7949	0.5
Schistosoma mansoni	serine/threonine RGC	0.0293	0.7949	1
Onchocerca volvulus		0.0293	0.7949	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0293	0.7949	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0293	0.7949	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0293	0.7949	1
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Onchocerca volvulus		0.0293	0.7949	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0293	0.7949	0.5
Schistosoma mansoni	protein tyrosine kinase	0.0293	0.7949	1
Onchocerca volvulus		0.0293	0.7949	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Onchocerca volvulus		0.0293	0.7949	0.5
Giardia lamblia	Kinase, NEK	0.0293	0.7949	0.5
Echinococcus multilocularis	protein kinase	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0293	0.7949	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0293	0.7949	0.5
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	heat shock protein 70	0.0293	0.7949	1
Schistosoma mansoni	ephrin receptor	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0293	0.7949	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Schistosoma mansoni	serine/threonine protein kinase	0.0293	0.7949	1
Brugia malayi	ephrin receptor 1 precursor	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0293	0.7949	1
Echinococcus granulosus	protein kinase	0.0293	0.7949	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0293	0.7949	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0293	0.7949	1
Plasmodium falciparum	protein kinase, putative	0.0293	0.7949	0.5
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Brugia malayi	hypothetical protein	0.0293	0.7949	1
Trichomonas vaginalis	conserved hypothetical protein	0.0293	0.7949	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0293	0.7949	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0293	0.7949	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0293	0.7949	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Onchocerca volvulus		0.0293	0.7949	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0293	0.7949	0.5
Echinococcus multilocularis	activin receptor type	0.0293	0.7949	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0293	0.7949	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0293	0.7949	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0293	0.7949	0.5
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0293	0.7949	0.5
Echinococcus granulosus	tyrosine kinase	0.0293	0.7949	1
Giardia lamblia	Kinase	0.0293	0.7949	0.5
Echinococcus granulosus	insulin receptor	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Echinococcus granulosus	c src tyrosine kinase	0.0293	0.7949	1
Brugia malayi	hypothetical protein	0.0293	0.7949	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0293	0.7949	1
Toxoplasma gondii	STE kinase	0.0293	0.7949	0.5
Schistosoma mansoni	hypothetical protein	0.0293	0.7949	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Plasmodium falciparum	protein kinase, putative	0.0293	0.7949	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0293	0.7949	0.5
Brugia malayi	SH2 domain containing protein	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0293	0.7949	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Brugia malayi	hypothetical protein	0.0293	0.7949	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0293	0.7949	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0293	0.7949	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Brugia malayi	SH2 domain containing protein	0.0293	0.7949	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0293	0.7949	1
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0293	0.7949	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0293	0.7949	1
Trichomonas vaginalis	TK family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0293	0.7949	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0293	0.7949	1
Schistosoma mansoni	ephrin receptor	0.0293	0.7949	1
Loa Loa (eye worm)	TK protein kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Onchocerca volvulus		0.0293	0.7949	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Echinococcus multilocularis	integrin linked protein kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0293	0.7949	1
Onchocerca volvulus		0.0293	0.7949	0.5
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Schistosoma mansoni	protein kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Onchocerca volvulus		0.0293	0.7949	0.5
Giardia lamblia	Protein 21.1	0.0293	0.7949	0.5
Brugia malayi	integrin-linked kinase	0.0293	0.7949	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0293	0.7949	1
Echinococcus multilocularis	protein kinase	0.0293	0.7949	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0293	0.7949	1
Echinococcus multilocularis	transfer RNA-Thr	0.0293	0.7949	1
Brugia malayi	SRC-1	0.0293	0.7949	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0293	0.7949	1
Schistosoma mansoni	protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Loa Loa (eye worm)	TK protein kinase	0.0293	0.7949	1
Trichomonas vaginalis	AGC family protein kinase	0.0293	0.7949	0.5
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0293	0.7949	0.5
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	TK protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0293	0.7949	1
Echinococcus granulosus	protein tyrosine kinase	0.0293	0.7949	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0293	0.7949	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0293	0.7949	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0293	0.7949	0.5
Onchocerca volvulus		0.0293	0.7949	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TK protein kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Brugia malayi	Protein kinase domain containing protein	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0293	0.7949	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0293	0.7949	1
Schistosoma mansoni	serine/threonine protein kinase	0.0293	0.7949	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0293	0.7949	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0293	0.7949	1
Trichomonas vaginalis	conserved hypothetical protein	0.0293	0.7949	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Trichomonas vaginalis	STE family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0293	0.7949	1
Schistosoma mansoni	tyrosine kinase	0.0293	0.7949	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0293	0.7949	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0293	0.7949	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0293	0.7949	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0293	0.7949	1
Leishmania major	hypothetical protein, conserved	0.0293	0.7949	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0293	0.7949	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0293	0.7949	0.5
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0293	0.7949	1
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Loa Loa (eye worm)	hypothetical protein	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0293	0.7949	1
Loa Loa (eye worm)	TK protein kinase	0.0293	0.7949	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0293	0.7949	1
Trichomonas vaginalis	TKL family protein kinase	0.0293	0.7949	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0293	0.7949	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0293	0.7949	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0293	0.7949	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0293	0.7949	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.1 uM	Inhibition of human BuChE using butyrylthiocholine as substrate by Ellman's method	ChEMBL.	24378710
IC50 (binding)	> 10 uM	Inhibition of human AChE using acetylthiocholine as substrate by Ellman's method	ChEMBL.	24378710
Inhibition (binding)		Competitive inhibition of AChE (unknown origin) by Lineweaver-Burk double reciprocal plot analysis	ChEMBL.	24378710
Ki (binding)	= 0.028 uM	Competitive inhibition of BuChE (unknown origin) using butyrylthiocholine as substrate by Lineweaver-Burk double reciprocal plot analysis	ChEMBL.	24378710
Ki (binding)	= 5.4 uM	Displacement of [3H]-CP55940 from human CB2 receptor transfected in HEK-293EBNA cells after 90 mins by luminescence counting analysis	ChEMBL.	24378710
Ki (binding)	> 40 uM	Displacement of [3H]-CP55940 from human CB1 receptor transfected in HEK-293EBNA cells after 90 mins by luminescence counting analysis	ChEMBL.	24378710

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3116282

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1832797