Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 472 aa | 27.5 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Loa Loa (eye worm) | hypothetical protein | Cholinesterase | 574 aa | 520 aa | 27.1 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Cholinesterase | 574 aa | 590 aa | 25.1 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Echinococcus granulosus | BC026374 protein S09 family | Cholinesterase | 574 aa | 642 aa | 34.4 % |
Loa Loa (eye worm) | hypothetical protein | Cholinesterase | 574 aa | 573 aa | 26.4 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Cholinesterase | 574 aa | 636 aa | 34.9 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Echinococcus multilocularis | neuroligin | Cholinesterase | 574 aa | 493 aa | 26.2 % |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Cholinesterase | 574 aa | 560 aa | 29.3 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Cholinesterase | 574 aa | 547 aa | 29.4 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 586 aa | 27.1 % | |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 549 aa | 29.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.2 uM | Inhibition of human AChE using acetylthiocholine as substrate by Ellman's method | ChEMBL. | 24378710 |
IC50 (binding) | > 10 uM | Inhibition of human BuChE using butyrylthiocholine as substrate by Ellman's method | ChEMBL. | 24378710 |
IC50 (binding) | > 10 uM | Inhibition of horse serum BuChE using butyrylthiocholine as substrate by Ellman's method | ChEMBL. | 24378710 |
Ki (binding) | = 0.68 uM | Displacement of [3H]-CP55940 from human CB2 receptor transfected in HEK-293EBNA cells after 90 mins by luminescence counting analysis | ChEMBL. | 24378710 |
Ki (binding) | = 1.3 uM | Displacement of [3H]-CP55940 from human CB1 receptor transfected in HEK-293EBNA cells after 90 mins by luminescence counting analysis | ChEMBL. | 24378710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.