Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.261 | 0.296 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.261 | 0.296 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0043 | 0.0559 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0043 | 0.0559 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.261 | 0.243 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0298 | 0.1877 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0298 | 0.1877 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.261 | 0.243 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0043 | 0.0559 | 0.0401 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.0298 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.0298 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.261 | 0.243 |
Onchocerca volvulus | 0.0101 | 0.471 | 0.5 | |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0043 | 0.0559 | 0.0329 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0043 | 0.0559 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.1177 | 0.0962 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.0298 | 0.0062 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0043 | 0.0559 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.261 | 0.296 |
Schistosoma mansoni | alpha-glucosidase | 0.0151 | 0.8253 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0298 | 0.1877 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.0298 | 0.0062 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0298 | 0.0075 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.261 | 0.243 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0043 | 0.0559 | 0.5 |
Brugia malayi | RNA binding protein | 0.0072 | 0.261 | 0.243 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.261 | 0.243 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.261 | 0.243 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.261 | 0.296 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.0298 | 0.1877 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0043 | 0.0559 | 0.0329 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0043 | 0.0559 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.1177 | 0.0962 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0043 | 0.0559 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.261 | 0.243 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0043 | 0.0559 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0298 | 0.1877 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.1177 | 0.0962 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0298 | 0.1877 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0298 | 0.0075 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.1177 | 0.0962 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.1177 | 0.0962 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0043 | 0.0559 | 0.0329 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.0298 | 0.1877 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0298 | 0.1877 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.0298 | 0.1877 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1177 | 0.1172 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.1177 | 0.0962 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0043 | 0.0559 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1177 | 0.1172 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0043 | 0.0559 | 0.0329 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.0298 | 0.0062 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1177 | 0.1172 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0043 | 0.0559 | 0.0329 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0043 | 0.0559 | 1 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0043 | 0.0559 | 0.0329 |
Brugia malayi | Inositol-1 | 0.004 | 0.0298 | 0.0062 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.261 | 0.296 |
Schistosoma mansoni | alpha-glucosidase | 0.0151 | 0.8253 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0.115 g | Toxicity in ICR mouse assessed as change in testicle weight at 54 mg/kg, po qd for 7 days measured every day for 7 days (0.118 +/- 0.004 g) | ChEMBL. | 24445313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.