Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Cholinesterase | 574 aa | 590 aa | 25.1 % |
Echinococcus multilocularis | neuroligin | Cholinesterase | 574 aa | 493 aa | 26.2 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 586 aa | 27.1 % | |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Echinococcus granulosus | BC026374 protein S09 family | Cholinesterase | 574 aa | 642 aa | 34.4 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 549 aa | 29.5 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Loa Loa (eye worm) | hypothetical protein | Cholinesterase | 574 aa | 573 aa | 26.4 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Cholinesterase | 574 aa | 547 aa | 29.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Cholinesterase | 574 aa | 560 aa | 29.3 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Cholinesterase | 574 aa | 636 aa | 34.9 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 472 aa | 27.5 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Loa Loa (eye worm) | hypothetical protein | Cholinesterase | 574 aa | 520 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.016 | 0.2882 | 0.2882 |
Schistosoma mansoni | transient receptor potential channel | 0.0087 | 0.1108 | 0.1108 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.4947 | 0.4947 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0058 | 0.0392 | 0.0392 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.4947 | 0.4947 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0152 | 0.2684 | 0.2684 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0152 | 0.2684 | 0.2684 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0232 | 0.4617 | 0.4617 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0152 | 0.2684 | 0.2684 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0152 | 0.2684 | 0.2684 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0232 | 0.4617 | 0.4617 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0152 | 0.2684 | 0.2684 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.4947 | 0.4947 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0232 | 0.4617 | 0.4617 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0058 | 0.0392 | 0.0392 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0045 | 0.008 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1108 | 0.1108 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0152 | 0.2684 | 0.2684 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0152 | 0.2684 | 0.2684 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0045 | 0.008 | 0.008 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0232 | 0.4617 | 0.4617 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0058 | 0.0392 | 0.0392 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0152 | 0.2684 | 0.2684 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.4947 | 0.4947 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.4947 | 0.4947 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0045 | 0.008 | 0.008 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0084 | 0.1037 | 0.1037 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0087 | 0.1108 | 0.1108 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.4947 | 0.4947 |
Schistosoma mansoni | transient receptor potential channel | 0.0058 | 0.0392 | 0.0392 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.4947 | 0.4947 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0232 | 0.4617 | 0.4617 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0087 | 0.1108 | 0.1108 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0322 | 0.0322 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0232 | 0.4617 | 0.4617 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0232 | 0.4617 | 0.4617 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0058 | 0.0392 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.008 | 0.008 |
Schistosoma mansoni | transient receptor potential channel | 0.0058 | 0.0392 | 0.0392 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.4947 | 0.4947 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.4947 | 0.4947 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.4947 | 0.4947 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.4947 | 0.4947 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.4947 | 0.4947 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0232 | 0.4617 | 0.4617 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.016 | 0.2882 | 0.2882 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.4947 | 0.4947 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0087 | 0.1108 | 0.1108 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0084 | 0.1037 | 0.1037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.7 uM | Inhibition of human AChE using acetylthiocholine as substrate by Ellman's method | ChEMBL. | 24378710 |
IC50 (binding) | > 10 uM | Inhibition of human BuChE using butyrylthiocholine as substrate by Ellman's method | ChEMBL. | 24378710 |
IC50 (binding) | > 10 uM | Inhibition of horse serum BuChE using butyrylthiocholine as substrate by Ellman's method | ChEMBL. | 24378710 |
Ki (binding) | = 0.49 uM | Displacement of [3H]-CP55940 from human CB2 receptor transfected in HEK-293EBNA cells after 90 mins by luminescence counting analysis | ChEMBL. | 24378710 |
Ki (binding) | = 0.8 uM | Displacement of [3H]-CP55940 from human CB1 receptor transfected in HEK-293EBNA cells after 90 mins by luminescence counting analysis | ChEMBL. | 24378710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.