Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0069 | 0.0508 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.039 | 0.4527 | 0.4527 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.039 | 0.4527 | 0.4234 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.039 | 0.4527 | 0.4234 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0069 | 0.0508 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.039 | 0.4527 | 0.4234 |
Brugia malayi | hypothetical protein | 0.0436 | 0.5113 | 0.5113 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.039 | 0.4527 | 0.4234 |
Brugia malayi | nuclear receptor RXR | 0.039 | 0.4527 | 0.4527 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.039 | 0.4527 | 0.4234 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0069 | 0.0508 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.5113 | 0.5113 |
Brugia malayi | conserved hypotetical protein | 0.039 | 0.4527 | 0.4527 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.039 | 0.4527 | 0.4527 |
Schistosoma mansoni | nuclear hormone receptor | 0.039 | 0.4527 | 0.4234 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.0508 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.039 | 0.4527 | 0.4234 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.5113 | 0.5113 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.5113 | 0.5113 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0436 | 0.5113 | 0.4851 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.5113 | 0.5113 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0436 | 0.5113 | 0.5113 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.039 | 0.4527 | 0.4234 |
Brugia malayi | nuclear receptor NHR-67 | 0.039 | 0.4527 | 0.4527 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.039 | 0.4527 | 0.4527 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Brugia malayi | nuclear receptor RXR | 0.0436 | 0.5113 | 0.5113 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.039 | 0.4527 | 0.4234 |
Brugia malayi | ecdysone receptor | 0.039 | 0.4527 | 0.4527 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.039 | 0.4527 | 0.4527 |
Schistosoma mansoni | zinc finger protein | 0.039 | 0.4527 | 0.4234 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Brugia malayi | nuclear receptor NHR-88 | 0.039 | 0.4527 | 0.4527 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.039 | 0.4527 | 0.4234 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.039 | 0.4527 | 0.4234 |
Brugia malayi | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.0508 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.0508 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0436 | 0.5113 | 0.4851 |
Schistosoma mansoni | nuclear receptor | 0.039 | 0.4527 | 0.4234 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.039 | 0.4527 | 0.4234 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.039 | 0.4527 | 0.4527 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.039 | 0.4527 | 0.4234 |
Brugia malayi | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Loa Loa (eye worm) | DR-78 | 0.039 | 0.4527 | 0.4527 |
Brugia malayi | hypothetical protein | 0.0436 | 0.5113 | 0.5113 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0436 | 0.5113 | 0.5113 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.039 | 0.4527 | 0.4234 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0436 | 0.5113 | 0.4851 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0436 | 0.5113 | 0.5113 |
Brugia malayi | Nuclear hormone receptor E75 | 0.039 | 0.4527 | 0.4527 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.039 | 0.4527 | 0.4234 |
Brugia malayi | nuclear hormone receptor | 0.039 | 0.4527 | 0.4527 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0436 | 0.5113 | 0.4851 |
Schistosoma mansoni | nuclear hormone receptor | 0.039 | 0.4527 | 0.4234 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.039 | 0.4527 | 0.4527 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.039 | 0.4527 | 0.4234 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4527 | 0.4527 |
Brugia malayi | tailless protein | 0.039 | 0.4527 | 0.4527 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.5113 | 0.5113 |
Brugia malayi | Nuclear hormone receptor E75 | 0.039 | 0.4527 | 0.4527 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.039 | 0.4527 | 0.4527 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.039 | 0.4527 | 0.4234 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 100 nM | Displacement of [3H]-dexamethasone from human glucocorticoid receptor expressed in HEK293 cells | ChEMBL. | 24446728 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.