Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide Y receptor Y5 | Starlite/ChEMBL | References |
Homo sapiens | neuropeptide Y receptor Y1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | neuropeptide Y receptor Y1 | 384 aa | 345 aa | 22.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | sulfite reductase, putative | 0.0226 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0226 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0226 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0226 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0226 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0226 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0112 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0226 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.02 | 0.7743 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0226 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0112 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0139 | 0.2407 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0226 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.02 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0226 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0226 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0114 | 0.0151 | 0.0151 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0226 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0226 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0226 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0226 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0226 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0226 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0226 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0139 | 0.2407 | 0.2407 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0226 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0226 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0226 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 47 nM | Compound was tested for its affinity to bind with Neuropeptide Y receptor type 5 | ChEMBL. | 10866375 |
IC50 (binding) | = 47 nM | Compound was tested for its affinity to bind with Neuropeptide Y receptor type 5 | ChEMBL. | 10866375 |
IC50 (binding) | > 10000 nM | Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1 | ChEMBL. | 10866375 |
IC50 (binding) | > 10000 nM | Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1 | ChEMBL. | 10866375 |
Ki (binding) | = 32 nM | Binding affinity to NPY5 receptor | ChEMBL. | 21782428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.