Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.3011 | 0.3011 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.7466 | 0.7466 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.7466 | 0.7466 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.7466 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.7466 | 0.7466 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.7466 | 0.7466 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.5369 | 0.5369 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.4495 | 0.4495 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.3011 | 0.3011 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.5369 | 0.5369 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.4495 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.3011 | 0.67 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.2886 | 0.6421 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.2886 | 0.2886 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.3011 | 0.3011 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.2009 | 0.2009 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.2886 | 0.2886 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1492 | 0.1492 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.4495 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1625 | 0.1625 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.4495 | 0.4495 |
Schistosoma mansoni | lamin | 0.0032 | 0.5369 | 0.5369 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.4495 | 0.4495 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.4495 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.3011 | 0.4033 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.3011 | 1 |
Brugia malayi | hypothetical protein | 0.0041 | 0.7466 | 0.7466 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.3011 | 1 |
Onchocerca volvulus | 0.0032 | 0.5369 | 1 | |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.3011 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.3011 | 1 |
Onchocerca volvulus | 0.0032 | 0.5369 | 1 | |
Schistosoma mansoni | lamin | 0.0032 | 0.5369 | 0.5369 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.1625 | 0.1625 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.2009 | 0.2009 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.3011 | 0.3011 |
Onchocerca volvulus | 0.0028 | 0.4495 | 0.8371 | |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.5369 | 0.5369 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.3011 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.7466 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0021 | 0.2886 | 0.9584 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.4495 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.3011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.4495 | 0.4495 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.2886 | 0.2886 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.3011 | 0.67 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.4495 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.2626 | 0.5844 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.7466 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.3011 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.2626 | 0.5844 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.4495 | 0.4495 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.4495 | 0.4495 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0021 | 0.2886 | 0.6421 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.4495 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.5369 | 0.5369 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.4495 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.2626 | 0.5844 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.7466 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.5369 | 0.5369 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.2886 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.5237 | 0.5237 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.5369 | 0.5369 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.3011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.2886 | 0.2886 |
Echinococcus multilocularis | lamin | 0.0032 | 0.5369 | 0.5369 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.1625 | 0.1625 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.3011 | 0.67 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.4495 | 0.602 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.4495 | 0.602 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.5369 | 0.5369 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.3011 | 0.3011 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.4495 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.3011 | 0.3011 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0021 | 0.2886 | 0.9584 |
Echinococcus granulosus | lamin | 0.0032 | 0.5369 | 0.5369 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.2626 | 0.5844 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.3011 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.4495 | 0.602 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.2886 | 0.2886 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.4495 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.4495 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.3011 | 0.5 |
Echinococcus multilocularis | musashi | 0.0032 | 0.5369 | 0.5369 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.4495 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.5369 | 0.5369 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.4495 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5369 | 0.5369 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.4495 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.3011 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1492 | 0.1492 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.4495 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.4495 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC80 (functional) | = 0.25 ug ml-1 | Antifungal activity against Candida albicans SC5314 after 24 hrs by micro-broth dilution method | ChEMBL. | 24487187 |
MIC80 (functional) | = 1 ug ml-1 | Antifungal activity against Cryptococcus neoformans after 72 hrs by micro-broth dilution method | ChEMBL. | 24487187 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.