TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 435.863 | Formula: C22H18ClN5O3
H donors: 1 H acceptors: 5 LogP: 4.47 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)Oc1ccc2c(c1)c(nc(n2)n1ncc(c1)C(=O)O)N1CCCC1
InChi: 1S/C22H18ClN5O3/c23-15-3-5-16(6-4-15)31-17-7-8-19-18(11-17)20(27-9-1-2-10-27)26-22(25-19)28-13-14(12-24-28)21(29)30/h3-8,11-13H,1-2,9-10H2,(H,29,30)
InChiKey: YEHGRYMGRBBRMA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	egl-9 family hypoxia-inducible factor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131326	All targets in OG5_131326
Neospora caninum	2OG-Fe(II) oxygenase family protein, putative	Get druggable targets OG5_131326	All targets in OG5_131326

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	tailless protein	0.0379	0.4671	0.4671
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.001	0.0035	0.0035
Plasmodium falciparum	importin beta, putative	0.0032	0.0311	0.5
Loa Loa (eye worm)	hypothetical protein	0.0425	0.5241	0.5241
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671
Schistosoma mansoni	ets-related	0.0012	0.0058	0.0058
Echinococcus multilocularis	snurportin 1	0.034	0.4173	0.4173
Echinococcus multilocularis	importin subunit beta 1	0.0032	0.0311	0.0311
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.0012	0.0058	0.0058
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0425	0.5241	0.5241
Echinococcus granulosus	ETS transcription factor Elf 5	0.0012	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671
Brugia malayi	Pre-SET motif family protein	0.0034	0.0334	0.0334
Loa Loa (eye worm)	D-ets-2 protein	0.0012	0.0058	0.0058
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0035	0.0035
Brugia malayi	nuclear hormone receptor	0.0379	0.4671	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0425	0.5241	0.5241
Brugia malayi	N-terminal motif family protein	0.0199	0.2411	0.2411
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.0771	0.0771
Loa Loa (eye worm)	hypothetical protein	0.011	0.1292	0.1292
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0002	0.0007
Schistosoma mansoni	cpg binding protein	0.0033	0.0332	0.0332
Brugia malayi	Importin beta-1 subunit	0.0032	0.0311	0.0311
Brugia malayi	regulator of G-protein signaling egl-10	0.001	0.0035	0.0035
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0856	0.0856
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0379	0.4671	0.4671
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0349	0.0349
Schistosoma mansoni	nuclear hormone receptor	0.0379	0.4671	0.4671
Brugia malayi	hypothetical protein	0.0333	0.4095	0.4095
Loa Loa (eye worm)	hypothetical protein	0.0305	0.3743	0.3743
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0002	0.0007
Brugia malayi	nuclear receptor RXR	0.0379	0.4671	0.4671
Onchocerca volvulus		0.0333	0.4095	0.4095
Echinococcus granulosus	GPCR family 2	0.0035	0.0349	0.0349
Entamoeba histolytica	hypothetical protein	0.004	0.041	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0349	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0058	0.0058
Toxoplasma gondii	hypoxia- inducible factor prolyl hydroxylase (phd2), putative	0.0017	0.0131	0.1477
Onchocerca volvulus		0.0032	0.031	0.031
Loa Loa (eye worm)	prolyl 4-hydroxylase 2	0.0017	0.0131	0.0131
Schistosoma mansoni	hypothetical protein	0.0187	0.2258	0.2258
Schistosoma mansoni	hypothetical protein	0.0451	0.5574	0.5574
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0236	0.0737
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0349	0.0349
Trichomonas vaginalis	importin beta-1, putative	0.0026	0.0236	0.0737
Brugia malayi	Nuclear hormone receptor E75	0.0379	0.4671	0.4671
Schistosoma mansoni	prolyl 4-hydroxylase alpha subunit 1	0.0017	0.0131	0.0131
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.0007
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0035	0.0035
Echinococcus multilocularis	prolyl 4 hydroxylase subunit alpha 1	0.0017	0.0131	0.0131
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0002	0.0007
Brugia malayi	hypothetical protein	0.0379	0.4671	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0131	0.0131
Entamoeba histolytica	hypothetical protein	0.004	0.041	1
Toxoplasma gondii	oxidoreductase, 2OG-Fe(II) oxygenase family protein	0.0017	0.0131	0.1477
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0379	0.4671	0.4671
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0026	0.0026
Schistosoma mansoni	hypothetical protein	0.0075	0.0856	0.0856
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0236	0.0737
Schistosoma mansoni	hypothetical protein	0.0035	0.0349	0.0349
Loa Loa (eye worm)	nuclear hormone receptor	0.0379	0.4671	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0349	0.0349
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0379	0.4671	0.4671
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.0856	0.0856
Brugia malayi	hypothetical protein	0.004	0.041	0.041
Brugia malayi	hypothetical protein	0.0379	0.4671	0.4671
Echinococcus granulosus	ETS transcription factor Elf 1	0.0012	0.0058	0.0058
Echinococcus multilocularis	ewsr:fli fusion protein type	0.0012	0.0058	0.0058
Schistosoma mansoni	dishevelled	0.001	0.0035	0.0035
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0349	0.0349
Toxoplasma gondii	tetratricopeptide repeat-containing protein	0.0017	0.0131	0.1477
Brugia malayi	Ets-domain containing protein	0.008	0.0915	0.0915
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.001	0.0035	0.0035
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0334	0.0334
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0026	0.0026
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.041	0.041
Echinococcus multilocularis	dnaJ subfamily B	0.0451	0.5574	0.5574
Echinococcus granulosus	protein C ets 2	0.0012	0.0058	0.0058
Schistosoma mansoni	z-protein (S1r protein)	0.001	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.001	0.0035	0.0035
Schistosoma mansoni	nuclear hormone receptor	0.0379	0.4671	0.4671
Brugia malayi	nuclear hormone receptor family member odr-7	0.0379	0.4671	0.4671
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.0007
Brugia malayi	Nuclear hormone receptor-like 1	0.0425	0.5241	0.5241
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.0012	0.0058	0.0058
Echinococcus granulosus	importin subunit beta 1	0.0032	0.0311	0.0311
Onchocerca volvulus		0.0034	0.0334	0.0334
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0379	0.4671	0.4671
Schistosoma mansoni	dishevelled	0.001	0.0035	0.0035
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0334	0.0334
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0334	0.0334
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.011	0.1292	0.1292
Echinococcus granulosus	prolyl 4 hydroxylase subunit alpha 1	0.0017	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0425	0.5241	0.5241
Brugia malayi	CXXC zinc finger family protein	0.0032	0.031	0.031
Echinococcus granulosus	ETS transcription factor Elf 2	0.0012	0.0058	0.0058
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0199	0.2411	0.2411
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.031	0.031
Trichomonas vaginalis	helicase, putative	0.0007	0.0002	0.0007
Schistosoma mansoni	nuclear receptor	0.0379	0.4671	0.4671
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0051	0.0051
Brugia malayi	nuclear receptor NHR-67	0.0379	0.4671	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0058	0.0058
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.041	0.041
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.0007
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0035	0.0035
Trichomonas vaginalis	set domain proteins, putative	0.0262	0.32	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0032	0.0311	0.4279
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0012	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671
Brugia malayi	nuclear receptor RXR	0.0425	0.5241	0.5241
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671
Toxoplasma gondii	oxidoreductase, 2OG-Fe(II) oxygenase family protein	0.0017	0.0131	0.1477
Onchocerca volvulus		0.0262	0.32	0.32
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0002	0.0007
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0379	0.4671	0.4671
Echinococcus granulosus	thyroid hormone receptor alpha	0.0379	0.4671	0.4671
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.0007
Schistosoma mansoni	hypothetical protein	0.0187	0.2258	0.2258
Brugia malayi	Pre-SET motif family protein	0.023	0.2802	0.2802
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0035	0.0035
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0425	0.5241	0.5241
Echinococcus multilocularis	ets variant gene 4	0.0012	0.0058	0.0058
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0379	0.4671	0.4671
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0349	0.0349
Brugia malayi	ecdysone receptor	0.0379	0.4671	0.4671
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.0007
Brugia malayi	prolyl 4-hydroxylase	0.0017	0.0131	0.0131
Echinococcus granulosus	snurportin 1	0.034	0.4173	0.4173
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0334	0.0334
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0002	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0311	0.0311
Leishmania major	importin beta-1 subunit, putative	0.0026	0.0236	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0379	0.4671	0.4671
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0379	0.4671	0.4671
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0334	0.4632
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0035	0.0035
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0035	0.0035
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0379	0.4671	0.4671
Echinococcus granulosus	geminin	0.0187	0.2258	0.2258
Schistosoma mansoni	ets-related	0.0243	0.2955	0.2955
Echinococcus multilocularis	GA binding protein alpha chain	0.008	0.0915	0.0915
Echinococcus multilocularis	cpg binding protein	0.0033	0.0332	0.0332
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0026	0.0026
Schistosoma mansoni	hypothetical protein	0.0012	0.0058	0.0058
Loa Loa (eye worm)	DR-78	0.0379	0.4671	0.4671
Echinococcus granulosus	ETS transcription factor Elf 2	0.0012	0.0058	0.0058
Schistosoma mansoni	gabp alpha	0.008	0.0915	0.0915
Onchocerca volvulus		0.001	0.0035	0.0035
Echinococcus granulosus	cpg binding protein	0.0033	0.0332	0.0332
Brugia malayi	nuclear receptor NHR-88	0.0379	0.4671	0.4671
Echinococcus multilocularis	protein C ets 2	0.0012	0.0058	0.0058
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0035	0.0035
Loa Loa (eye worm)	fli-1 protein	0.0243	0.2955	0.2955
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0026	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.0007
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0002	0.0007
Entamoeba histolytica	hypothetical protein	0.0026	0.0236	0.5751
Brugia malayi	transcription factor E74 isoform	0.0012	0.0058	0.0058
Loa Loa (eye worm)	ets-domain-containing protein	0.0012	0.0058	0.0058
Schistosoma mansoni	zinc finger protein	0.0379	0.4671	0.4671
Schistosoma mansoni	hypothetical protein	0.0012	0.0058	0.0058
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0379	0.4671	0.4671
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0311	1
Echinococcus granulosus	ewsr:fli fusion protein type	0.0012	0.0058	0.0058
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0425	0.5241	0.5241
Loa Loa (eye worm)	hypothetical protein	0.0425	0.5241	0.5241
Brugia malayi	hypothetical protein	0.0425	0.5241	0.5241
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0002	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0334	0.0334
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0349	0.0349
Schistosoma mansoni	nuclear receptor nhr-48	0.0379	0.4671	0.4671
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0026	0.0236	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0425	0.5241	0.5241
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0379	0.4671	0.4671
Brugia malayi	Ets-domain containing protein	0.008	0.0915	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671
Loa Loa (eye worm)	hypothetical protein	0.001	0.0035	0.0035
Schistosoma mansoni	importin beta-1	0.0032	0.0311	0.0311
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.023	0.2802	0.2802
Brugia malayi	orphan nuclear receptor NR2E1	0.0379	0.4671	0.4671
Brugia malayi	DIX domain containing protein	0.001	0.0035	0.0035
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.011	0.1292	0.1292
Brugia malayi	hypothetical protein	0.001	0.0035	0.0035
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0334	0.0334
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.041	0.041
Echinococcus multilocularis	ETS transcription factor Elf 1	0.0012	0.0058	0.0058
Loa Loa (eye worm)	DIX domain-containing protein	0.001	0.0035	0.0035
Schistosoma mansoni	hypothetical protein	0.0035	0.0349	0.0349
Schistosoma mansoni	hypothetical protein	0.0035	0.0349	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671
Brugia malayi	DNA-binding protein D-ETS-3	0.0012	0.0058	0.0058
Echinococcus granulosus	nuclear receptor nhr 48	0.0379	0.4671	0.4671
Trypanosoma cruzi	2OG-Fe(II) oxygenase superfamily, putative	0.0017	0.0131	0.5535
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.031	0.031
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0035	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.0007
Entamoeba histolytica	hypothetical protein	0.004	0.041	1
Schistosoma mansoni	dep domain containing protein	0.001	0.0035	0.0035
Brugia malayi	conserved hypotetical protein	0.0379	0.4671	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0769	0.0769
Schistosoma mansoni	hypothetical protein	0.0035	0.0349	0.0349
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0379	0.4671	0.4671
Schistosoma mansoni	regulator of G protein signaling	0.001	0.0035	0.0035
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.001	0.0035	0.0035
Brugia malayi	Nuclear hormone receptor E75	0.0379	0.4671	0.4671
Echinococcus granulosus	dnaJ subfamily B	0.0451	0.5574	0.5574
Schistosoma mansoni	ets	0.0012	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0199	0.2411	0.2411
Echinococcus granulosus	ETS domain containing protein Elk 1	0.0012	0.0058	0.0058
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0334	0.0334
Brugia malayi	Ets-domain containing protein	0.0012	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671
Onchocerca volvulus		0.0379	0.4671	0.4671
Brugia malayi	Nuclear hormone receptor-like 1	0.0425	0.5241	0.5241
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.001	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0333	0.4095	0.4095
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0379	0.4671	0.4671
Brugia malayi	hypothetical protein	0.001	0.0035	0.0035
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0035	0.0035
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0311	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0002	0.0007
Echinococcus multilocularis	ETS domain containing protein Elk 1	0.0012	0.0058	0.0058
Echinococcus granulosus	GA binding protein alpha chain	0.008	0.0915	0.0915
Entamoeba histolytica	hypothetical protein	0.004	0.041	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0379	0.4671	0.4671
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0349	0.0349
Schistosoma mansoni	elf1	0.0012	0.0058	0.0058
Brugia malayi	hypothetical protein	0.0425	0.5241	0.5241
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0379	0.4671	0.4671
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0379	0.4671	0.4671
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0379	0.4671	0.4671
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0035	0.0035
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0379	0.4671	0.4671
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.034	0.4173	0.4173
Brugia malayi	Calcitonin receptor-like protein seb-1	0.011	0.1292	0.1292
Echinococcus granulosus	Pleckstrin G protein interacting region	0.001	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.001	0.0035	0.0035
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0002	0.0007
Schistosoma mansoni	nuclear receptor	0.0379	0.4671	0.4671
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0425	0.5241	0.5241
Schistosoma mansoni	cpg binding protein	0.0032	0.031	0.031
Schistosoma mansoni	cpg binding protein	0.0033	0.0332	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0425	0.5241	0.5241
Echinococcus multilocularis	geminin	0.0187	0.2258	0.2258
Echinococcus multilocularis	ETS transcription factor Elf 5	0.0012	0.0058	0.0058
Onchocerca volvulus		0.0017	0.0131	0.0131
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0012	0.0058	0.0058
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0334	0.0334
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.008	0.0915	0.0915
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0012	0.0058	0.0058
Schistosoma mansoni	hypothetical protein	0.004	0.041	0.041
Brugia malayi	RNA, U transporter 1	0.009	0.1047	0.1047
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0051	0.0051
Plasmodium vivax	SET domain protein, putative	0.0034	0.0334	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0026	0.0026
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.0681	1
Brugia malayi	Fli-1 protein	0.0243	0.2955	0.2955
Schistosoma mansoni	hypothetical protein	0.034	0.4173	0.4173
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0349	0.0349
Trypanosoma cruzi	2OG-Fe(II) oxygenase superfamily, putative	0.0017	0.0131	0.5535
Onchocerca volvulus		0.0379	0.4671	0.4671
Loa Loa (eye worm)	hypothetical protein	0.0379	0.4671	0.4671

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 50 nM	Inhibition of PHD2 (181 to 417) (unknown origin) using HIF-1alpha peptide as substrate assessed as 2-Oxoglutarate conversion to succinic acid preincubated for 30 mins followed by substrate addition measured after 30 mins by beta counting analysis	ChEMBL.	23977883

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3115314

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1833576