TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 323.819 | Formula: C19H18ClN3
H donors: 2 H acceptors: 1 LogP: 4.09 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C(c1ccc(cc1)c1c[nH]nc1)NC1CC1
InChi: 1S/C19H18ClN3/c20-17-7-5-15(6-8-17)19(23-18-9-10-18)14-3-1-13(2-4-14)16-11-21-22-12-16/h1-8,11-12,18-19,23H,9-10H2,(H,21,22)
InChiKey: MXKMQPQCKJWTCJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	v-akt murine thymoma viral oncogene homolog 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.052	0.9995	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.052	0.9995	1
Echinococcus multilocularis	nervana 2	0.0025	0.0234	0.0234
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0025	0.0234	0.0234
Echinococcus multilocularis	Glutaredoxin protein 5	0.0025	0.0234	0.0234
Entamoeba histolytica	tyrosin kinase, putative	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0028	0.0288	0.005
Plasmodium vivax	protein kinase, putative	0.052	0.9995	1
Onchocerca volvulus		0.052	0.9995	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.052	0.9995	0.9995
Echinococcus granulosus	tyrosine protein kinase Fyn	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.052	0.9995	0.9995
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.052	0.9995	0.9995
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Loa Loa (eye worm)	AGC/AKT protein kinase	0.004	0.0537	0.0537
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.052	0.9995	0.9995
Trichomonas vaginalis	conserved hypothetical protein	0.052	0.9995	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus granulosus	protein kinase	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Schistosoma mansoni	protein kinase	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	conserved hypothetical protein	0.052	0.9995	1
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/INSR protein kinase	0.052	0.9995	1
Schistosoma mansoni	hypothetical protein	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Trichomonas vaginalis	AGC family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.052	0.9995	1
Trichomonas vaginalis	protein kinase atn1, putative	0.052	0.9995	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Entamoeba histolytica	hypothetical protein	0.052	0.9995	0.9995
Trypanosoma cruzi	Protein kinase B	0.0028	0.0288	0.005
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Echinococcus granulosus	Glutaredoxin protein 5	0.0025	0.0234	0.0234
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.052	0.9995	0.9995
Echinococcus granulosus	raf serine:threonine protein kinase	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Brugia malayi	bone morphogenetic protein type 1 receptor	0.052	0.9995	1
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Entamoeba histolytica	hypothetical protein, conserved	0.052	0.9995	0.9995
Entamoeba histolytica	hypothetical protein	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Entamoeba histolytica	hypothetical protein	0.052	0.9995	0.9995
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	hypothetical protein	0.052	0.9995	0.9995
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.052	0.9995	0.9995
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.052	0.9995	0.9995
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Schistosoma mansoni	protein kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/FAK protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Echinococcus multilocularis	epidermal growth factor receptor	0.052	0.9995	0.9995
Echinococcus granulosus	tyrosine protein kinase Src42A	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.052	0.9995	0.9995
Echinococcus granulosus	serine/threonine protein kinase	0.0028	0.0288	0.0288
Trichomonas vaginalis	conserved hypothetical protein	0.052	0.9995	1
Loa Loa (eye worm)	TK protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Schistosoma mansoni	serine/threonine RGC	0.052	0.9995	0.9995
Loa Loa (eye worm)	RGC/RGC protein kinase	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.052	0.9995	0.9995
Echinococcus granulosus	serine threonine protein kinase nrc	0.0025	0.0239	0.0239
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine protein kinase pr2	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.052	0.9995	1
Echinococcus granulosus	tyrosine kinase	0.052	0.9995	0.9995
Echinococcus granulosus	tyrosine protein kinase Fyn	0.052	0.9995	0.9995
Schistosoma mansoni	protein kinase	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Echinococcus multilocularis	c src tyrosine kinase	0.052	0.9995	0.9995
Entamoeba histolytica	receptor protein kinase, putative	0.052	0.9995	0.9995
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.052	0.9995	0.9995
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.052	0.9995	0.9995
Trichomonas vaginalis	protein tyrosine kinase, putative	0.052	0.9995	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.052	0.9995	0.9995
Onchocerca volvulus		0.052	0.9995	0.5
Brugia malayi	hypothetical protein	0.052	0.9995	1
Entamoeba histolytica	hypothetical protein	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK protein kinase	0.052	0.9995	1
Toxoplasma gondii	protein kinase	0.052	0.9995	0.9994
Echinococcus multilocularis	tyrosine protein kinase csk	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Echinococcus granulosus	nervana 2	0.0025	0.0234	0.0234
Onchocerca volvulus		0.052	0.9995	0.5
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0537	0.0537
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK protein kinase	0.052	0.9995	1
Echinococcus granulosus	protein tyrosine kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Onchocerca volvulus		0.052	0.9995	0.5
Echinococcus multilocularis	insulin receptor	0.052	0.9995	0.9995
Entamoeba histolytica	ankyrin repeat protein	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.052	0.9995	0.9995
Entamoeba histolytica	serine/threonine kinase, putative	0.052	0.9995	0.9995
Brugia malayi	SRC-1	0.052	0.9995	1
Brugia malayi	Furin-like cysteine rich region family protein	0.052	0.9995	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.052	0.9995	1
Entamoeba histolytica	serine/threonine kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Entamoeba histolytica	hypothetical protein	0.052	0.9995	0.9995
Onchocerca volvulus		0.052	0.9995	0.5
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0025	0.0239	0.0239
Brugia malayi	Tyrosine-protein kinase abl-1	0.052	0.9995	1
Brugia malayi	Tyrosine-protein kinase PR2	0.052	0.9995	1
Entamoeba histolytica	receptor protein kinase, putative	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Echinococcus granulosus	tyrosine protein kinase	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.052	0.9995	0.9994
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Entamoeba histolytica	tyrosin kinase, putative	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus multilocularis	protein kinase	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Echinococcus granulosus	retinal guanylyl cyclase 2	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Trichomonas vaginalis	conserved hypothetical protein	0.052	0.9995	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.052	0.9995	0.9995
Trichomonas vaginalis	CAMK family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Giardia lamblia	Kinase, NEK	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Brugia malayi	hypothetical protein	0.052	0.9995	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.052	0.9995	0.9995
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.052	0.9995	0.9995
Brugia malayi	Guanylyl cyclase protein 23	0.052	0.9995	1
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Echinococcus multilocularis	protein tyrosine kinase	0.052	0.9995	0.9995
Echinococcus multilocularis	natriuretic peptide receptor 1	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Echinococcus multilocularis	receptor type guanylyl cyclase	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine protein kinase Blk	0.052	0.9995	0.9995
Entamoeba histolytica	hypothetical protein	0.052	0.9995	0.9995
Echinococcus granulosus	c src tyrosine kinase	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.052	0.9995	0.9995
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.052	0.9995	0.9995
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.052	0.9995	1
Schistosoma mansoni	protein kinase	0.052	0.9995	0.9995
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.052	0.9995	0.9995
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.052	0.9995	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.052	0.9995	0.9995
Giardia lamblia	Kinase, NEK	0.052	0.9995	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.052	0.9995	0.9995
Onchocerca volvulus		0.052	0.9995	0.5
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Plasmodium falciparum	protein kinase, putative	0.052	0.9995	0.9994
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Onchocerca volvulus		0.052	0.9995	0.5
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.052	0.9995	0.9995
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0025	0.0239	0.0239
Onchocerca volvulus		0.052	0.9995	0.5
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.052	0.9995	0.9995
Trypanosoma brucei	Pseudokinase, putative	0.052	0.9995	0.9994
Brugia malayi	SH2 domain containing protein	0.052	0.9995	1
Entamoeba histolytica	hypothetical protein	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine protein kinase Srms	0.052	0.9995	0.9995
Schistosoma mansoni	serine/threonine protein kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Trichomonas vaginalis	conserved hypothetical protein	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.052	0.9995	0.9995
Brugia malayi	protein-tyrosine kinase	0.052	0.9995	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0288	0.0288
Echinococcus granulosus	receptor type guanylyl cyclase	0.052	0.9995	0.9995
Entamoeba histolytica	hypothetical protein	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Brugia malayi	ephrin receptor 1 precursor	0.052	0.9995	1
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.052	0.9995	0.9995
Onchocerca volvulus		0.052	0.9995	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Schistosoma mansoni	protein kinase	0.052	0.9995	0.9995
Echinococcus multilocularis	nervana 2	0.0025	0.0234	0.0234
Brugia malayi	C-terminal src kinase protein 1	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK protein kinase	0.052	0.9995	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.052	0.9995	0.9995
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0537	0.0537
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.052	0.9995	0.9995
Echinococcus multilocularis	protein kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Entamoeba histolytica	serine/threonine kinase, putative	0.052	0.9995	0.9995
Echinococcus multilocularis	transfer RNA-Thr	0.052	0.9995	0.9995
Echinococcus granulosus	tyrosine protein kinase Src64B	0.052	0.9995	0.9995
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Loa Loa (eye worm)	SRC-1	0.052	0.9995	1
Loa Loa (eye worm)	TK/Met protein kinase	0.052	0.9995	1
Trypanosoma cruzi	protein kinase, putative	0.052	0.9995	0.9994
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Schistosoma mansoni	serine/threonine protein kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.052	0.9995	0.9995
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.052	0.9995	0.9994
Echinococcus multilocularis	heat shock protein 70	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Entamoeba histolytica	hypothetical protein	0.052	0.9995	0.9995
Echinococcus granulosus	insulin receptor	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.0288	0.0288
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.052	0.9995	0.9995
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Brugia malayi	integrin-linked kinase	0.052	0.9995	1
Entamoeba histolytica	serine/threonine kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	ankyrin repeat protein	0.052	0.9995	0.9995
Schistosoma mansoni	protein kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.004	0.0537	0.0537
Plasmodium falciparum	tyrosine kinase-like protein	0.052	0.9995	0.9994
Loa Loa (eye worm)	TK/CSK protein kinase	0.052	0.9995	1
Onchocerca volvulus		0.052	0.9995	0.5
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.052	0.9995	1
Schistosoma mansoni	protein kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Echinococcus granulosus	integrin linked protein kinase	0.052	0.9995	0.9995
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.052	0.9995	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Echinococcus granulosus	retinal guanylyl cyclase 2	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/DDR protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TK protein kinase	0.052	0.9995	1
Brugia malayi	SH2 domain containing protein	0.052	0.9995	1
Brugia malayi	Receptor family ligand binding region containing protein	0.052	0.9995	1
Plasmodium falciparum	protein kinase, putative	0.052	0.9995	0.9994
Brugia malayi	Immunoglobulin I-set domain containing protein	0.052	0.9995	1
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.0038	0.0488	0.0488
Echinococcus granulosus	nervana 2	0.0025	0.0234	0.0234
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0049	0.0049
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Brugia malayi	p70 ribosomal S6 kinase beta	0.0038	0.0488	0.0488
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0537	0.0537
Plasmodium vivax	tyrosine kinase-like protein, putative	0.052	0.9995	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0537	0.0537
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.052	0.9995	1
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TK protein kinase	0.052	0.9995	1
Echinococcus granulosus	tyrosine protein kinase shark	0.052	0.9995	0.9995
Echinococcus granulosus	tyrosine protein kinase Fyn	0.052	0.9995	0.9995
Trichomonas vaginalis	STE family protein kinase	0.052	0.9995	1
Entamoeba histolytica	hypothetical protein	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.052	0.9995	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Echinococcus granulosus	epidermal growth factor receptor	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase 2, putative	0.0025	0.0239	0.0239
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Echinococcus granulosus	activated cdc42 kinase 1	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus granulosus	tyrosine protein kinase csk	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine protein kinase Abl	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.052	0.9995	0.9995
Loa Loa (eye worm)	protein kinase domain-containing protein	0.052	0.9995	1
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.052	0.9995	1
Schistosoma mansoni	ephrin receptor	0.052	0.9995	0.9995
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.052	0.9995	0.9995
Trypanosoma cruzi	protein kinase, putative	0.052	0.9995	0.9994
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Echinococcus multilocularis	epidermal growth factor receptor	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine protein kinase csk	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein kinase, putative	0.004	0.0537	0.0537
Onchocerca volvulus		0.052	0.9995	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.052	0.9995	1
Schistosoma mansoni	protein tyrosine kinase	0.052	0.9995	0.9995
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.052	0.9995	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.052	0.9995	0.9995
Echinococcus granulosus	epidermal growth factor receptor	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Trichomonas vaginalis	TK family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.052	0.9995	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Giardia lamblia	Kinase	0.052	0.9995	1
Echinococcus multilocularis	tyrosine protein kinase	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Schistosoma mansoni	serine/threonine protein kinase	0.052	0.9995	0.9995
Giardia lamblia	Protein 21.1	0.052	0.9995	1
Loa Loa (eye worm)	hypothetical protein	0.052	0.9995	1
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Onchocerca volvulus		0.052	0.9995	0.5
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Brugia malayi	Raf kinase	0.052	0.9995	1
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Entamoeba histolytica	serine/threonine kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	tyrosin kinase, putative	0.052	0.9995	0.9995
Schistosoma mansoni	protein kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.052	0.9995	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0288	0.0288
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.052	0.9995	0.9995
Onchocerca volvulus	Tyrosine kinase homolog	0.052	0.9995	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Trichomonas vaginalis	conserved hypothetical protein	0.052	0.9995	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.052	0.9995	1
Echinococcus multilocularis	FL cytokine receptor	0.052	0.9995	0.9995
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.052	0.9995	0.9995
Schistosoma mansoni	ephrin receptor	0.052	0.9995	0.9995
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.052	0.9995	0.5
Loa Loa (eye worm)	TK protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.052	0.9995	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0537	0.0537
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0025	0.0234	0.0234
Echinococcus granulosus	activated cdc42 kinase 1	0.052	0.9995	0.9995
Echinococcus multilocularis	integrin linked protein kinase	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.052	0.9995	1
Brugia malayi	hypothetical protein	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.052	0.9995	1
Echinococcus granulosus	tyrosine protein kinase csk	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.004	0.0537	0.0537
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine protein kinase	0.052	0.9995	0.9995
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0537	0.0537
Toxoplasma gondii	STE kinase	0.052	0.9995	0.9994
Echinococcus granulosus	tyrosine kinase	0.052	0.9995	0.9995
Onchocerca volvulus		0.052	0.9995	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.052	0.9995	0.9995
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.052	0.9995	0.9995
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.0288	0.0288
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.052	0.9995	0.9995
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.052	0.9995	0.9994
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Loa Loa (eye worm)	TK protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.052	0.9995	0.9995
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.052	0.9995	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.052	0.9995	1
Plasmodium falciparum	tyrosine kinase-like protein	0.052	0.9995	0.9994
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0537	0.0537
Entamoeba histolytica	tyrosin kinase, putative	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.052	0.9995	0.9995
Trypanosoma brucei	Flagellum attachment zone protein 20	0.052	0.9995	0.9994
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Onchocerca volvulus		0.052	0.9995	0.5
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Schistosoma mansoni	serine/threonine protein kinase	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Toxoplasma gondii	protein kinase domain-containing protein	0.052	0.9995	0.9994
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase domain containing protein	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.052	0.9995	0.9995
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0038	0.0488	0.0488
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.052	0.9995	0.9995
Echinococcus granulosus	tyrosine kinase	0.052	0.9995	0.9995
Trichomonas vaginalis	TKL family protein kinase	0.052	0.9995	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.052	0.9995	0.9995
Echinococcus granulosus	tyrosine protein kinase csk	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/FER protein kinase	0.052	0.9995	1
Echinococcus multilocularis	rac serine:threonine kinase	0.0028	0.0288	0.0288
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.052	0.9995	0.9995
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.052	0.9995	1
Onchocerca volvulus		0.052	0.9995	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.052	0.9995	0.9995
Schistosoma mansoni	tyrosine kinase	0.052	0.9995	0.9995
Loa Loa (eye worm)	RGC/RGC protein kinase	0.052	0.9995	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.052	0.9995	0.9995
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.052	0.9995	1
Entamoeba histolytica	tyrosine kinase, putative	0.052	0.9995	0.9995
Entamoeba histolytica	cysteine surface protein, putative	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.052	0.9995	1
Brugia malayi	Protein kinase domain containing protein	0.052	0.9995	1
Loa Loa (eye worm)	TK protein kinase	0.052	0.9995	1
Trichomonas vaginalis	conserved hypothetical protein	0.052	0.9995	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.052	0.9995	0.9995
Entamoeba histolytica	protein kinase, putative	0.052	0.9995	0.9995

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.48 uM	Inhibition of Akt1 (unknown origin) using ATP/eNOS as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by fluorescence polarization assay	ChEMBL.	24389511
IC50 (functional)	= 15.6 uM	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	ChEMBL.	24389511

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24389511

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3113145

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1833893