Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cation transporter family protein | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | 484 aa | 469 aa | 28.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0588 | 0.2258 | 0.2941 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0944 | 0.4773 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0639 | 0.2616 | 0.3495 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0741 | 0.3337 | 0.4398 |
Mycobacterium ulcerans | thioesterase TesA | 0.0741 | 0.3337 | 0.443 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0944 | 0.4773 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0944 | 0.4773 | 0.6337 |
Brugia malayi | AMP-binding enzyme family protein | 0.0831 | 0.3971 | 0.3971 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0944 | 0.4773 | 0.6376 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0588 | 0.2258 | 0.2981 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0889 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0505 | 0.1676 | 0.224 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0633 | 0.2576 | 0.3708 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0727 | 0.324 | 0.4329 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0944 | 0.4773 | 0.6337 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1603 | 0.9418 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0944 | 0.4773 | 0.6357 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1329 | 0.7486 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0889 | 0.4383 | 0.5834 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1329 | 0.7486 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0273 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.1494 | 0.8648 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0889 | 0.4383 | 0.5856 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0831 | 0.3971 | 0.5305 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0741 | 0.3337 | 0.4459 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0715 | 0.3157 | 0.4155 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1329 | 0.7486 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0741 | 0.3337 | 0.443 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0889 | 0.4383 | 0.5856 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.036 | 0.0647 | 0.0864 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0889 | 0.4383 | 0.5834 |
Onchocerca volvulus | 0.1547 | 0.9028 | 0.9285 | |
Loa Loa (eye worm) | hypothetical protein | 0.0498 | 0.1625 | 0.0823 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0862 | 0.4191 | 0.5599 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0889 | 0.4383 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0889 | 0.4383 | 0.581 |
Mycobacterium ulcerans | polyketide synthase | 0.0944 | 0.4773 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0862 | 0.4191 | 0.5599 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0889 | 0.4383 | 0.581 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0279 | 0.0081 | 0.0056 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1329 | 0.7486 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0889 | 0.4383 | 0.5834 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0577 | 0.218 | 0.2574 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0715 | 0.3157 | 0.4188 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0273 | 0.0039 | 0.0052 |
Loa Loa (eye worm) | fatty acid synthase | 0.0877 | 0.43 | 0.4318 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0889 | 0.4383 | 0.4383 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0831 | 0.3971 | 0.3889 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0944 | 0.4773 | 0.6376 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0279 | 0.0081 | 0.0108 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0588 | 0.2258 | 0.2981 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0306 | 0.0267 | 0.0356 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0944 | 0.4773 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0715 | 0.3157 | 0.4188 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0889 | 0.4383 | 0.5856 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0944 | 0.4773 | 0.6376 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1 nM | Binding affinity to human HT3A receptor | ChEMBL. | 20889341 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.