Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 12-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | arachidonate 12-lipoxygenase | 663 aa | 662 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0052 | 0.6588 | 0.5 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0052 | 0.6588 | 0.5 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0052 | 0.6588 | 0.6588 |
Echinococcus multilocularis | fk506 binding protein | 0.0052 | 0.6588 | 0.3302 |
Brugia malayi | Matrixin family protein | 0.0041 | 0.3972 | 0.603 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0052 | 0.6588 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0052 | 0.6588 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0052 | 0.6588 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0052 | 0.6588 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0038 | 0.3178 | 1 |
Schistosoma mansoni | immunophilin | 0.0052 | 0.6588 | 0.6588 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0052 | 0.6588 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0045 | 0.4906 | 0.4906 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0052 | 0.6588 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0038 | 0.3178 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0052 | 0.6588 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0052 | 0.6588 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0041 | 0.3972 | 0.2329 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0052 | 0.6588 | 0.3302 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0052 | 0.6588 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.004 | 0.3802 | 0.3802 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0062 | 0.8811 | 0.7665 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0052 | 0.6588 | 0.5 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0052 | 0.6588 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0052 | 0.6588 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0052 | 0.6588 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.0052 | 0.6588 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.0052 | 0.6588 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0052 | 0.6588 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0052 | 0.6588 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0052 | 0.6588 | 0.5 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0052 | 0.6588 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4906 | 0.5068 |
Loa Loa (eye worm) | FKBP5 protein | 0.0052 | 0.6588 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0062 | 0.8811 | 0.7665 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0052 | 0.6588 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0052 | 0.6588 | 0.3302 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0052 | 0.6588 | 1 |
Schistosoma mansoni | immunophilin | 0.0052 | 0.6588 | 0.6588 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0052 | 0.6588 | 0.3302 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.7 uM | Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysis | ChEMBL. | 24393039 |
Inhibition (binding) | = 70 % | Inhibition of N-terminal His6-tagged human reticulocyte 15-LOX1 using arachidonic acid as substrate at 25 uM by UV-vis spectrophotometric analysis relative to control | ChEMBL. | 24393039 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.