TDR Targets

Basic information

Technical information

TDR Targets ID: 1834517
Name: 1-(3-chlorophenyl)-3-(2-chloropyridin-3-yl)th iourea
MW: 298.191 | Formula: C12H9Cl2N3S
H donors: 2 H acceptors: 1 LogP: 3.6 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: S=C(Nc1cccnc1Cl)Nc1cccc(c1)Cl
InChi: 1S/C12H9Cl2N3S/c13-8-3-1-4-9(7-8)16-12(18)17-10-5-2-6-15-11(10)14/h1-7H,(H2,16,17,18)
InChiKey: KODXKOWHPOTHRF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(3-chlorophenyl)-3-(2-chloro-3-pyridyl)thiourea
Oprea1_705677

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0017	0.051	0.051
Echinococcus granulosus	transient receptor potential cation channel	0.0017	0.0511	0.0511
Echinococcus granulosus	hyperpolarization activated cyclic	0.0017	0.051	0.051
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0017	0.051	0.051
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0017	0.051	0.051
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0017	0.051	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0017	0.051	0.0076
Echinococcus multilocularis	potassium voltage gated channel protein	0.0017	0.051	0.051
Brugia malayi	intermediate filament protein	0.0031	0.4263	0.4001
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.0511	0.0511
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.4263	0.4263
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0017	0.051	0.051
Echinococcus multilocularis	lamin dm0	0.0031	0.4263	0.4263
Loa Loa (eye worm)	voltage-gated potassium channel	0.0017	0.051	0.051
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.051	0.051
Echinococcus granulosus	hypothetical protein	0.0017	0.051	0.051
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0017	0.051	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0017	0.051	0.051
Echinococcus granulosus	voltage dependent calcium channel	0.0017	0.051	0.051
Brugia malayi	cation channel family protein	0.0017	0.051	0.0076
Schistosoma mansoni	lamin	0.0031	0.4263	0.3955
Echinococcus multilocularis	voltage dependent calcium channel	0.0017	0.051	0.051
Echinococcus granulosus	shaker cognate	0.0017	0.051	0.051
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0017	0.051	0.051
Echinococcus multilocularis	transient receptor potential gamma protein	0.0017	0.051	0.051
Echinococcus granulosus	voltage gated potassium channel	0.0017	0.051	0.051
Echinococcus multilocularis	potassium voltage gated channel protein	0.0017	0.051	0.051
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0017	0.051	0.051
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0017	0.051	0.0076
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0017	0.051	0.051
Echinococcus granulosus	potassium large conductance calcium activated	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0031	0.4263	0.4263
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0017	0.051	0.051
Echinococcus granulosus	transient receptor potential cation channel	0.0017	0.0511	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0017	0.051	0.0076
Leishmania major	hypothetical protein, unknown function	0.0017	0.051	0.5
Echinococcus granulosus	sodium channel protein	0.0017	0.051	0.051
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0017	0.051	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0017	0.051	0.051
Echinococcus multilocularis	voltage gated potassium channel	0.0017	0.051	0.051
Echinococcus multilocularis	voltage dependent calcium channel	0.0017	0.051	0.051
Echinococcus multilocularis	sodium leak channel non selective protein	0.0017	0.051	0.051
Echinococcus multilocularis	short transient receptor potential channel 6	0.0017	0.051	0.051
Leishmania major	hypothetical protein, conserved	0.0017	0.051	0.5
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0017	0.051	0.051
Toxoplasma gondii	transporter, cation channel family protein	0.0017	0.051	0.5
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0017	0.051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.4263	0.4263
Echinococcus granulosus	TRP transient receptor potential channel	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0511	0.0511
Loa Loa (eye worm)	ion channel NompC	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Schistosoma mansoni	intermediate filament proteins	0.0031	0.4263	0.3955
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.0511	0.0511
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0017	0.051	0.051
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.051	0.051
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0017	0.051	0.0076
Brugia malayi	Transient-receptor-potential like protein	0.0017	0.051	0.0076
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0017	0.051	0.0076
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0017	0.051	0.051
Echinococcus granulosus	transient receptor potential cation channel	0.0017	0.051	0.051
Schistosoma mansoni	transient receptor potential channel	0.0017	0.0511	0.0000024361
Echinococcus granulosus	hyperpolarization activated cyclic	0.0017	0.051	0.051
Echinococcus granulosus	two pore calcium channel protein 1	0.0017	0.051	0.051
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0017	0.051	0.051
Toxoplasma gondii	transporter, cation channel family protein	0.0017	0.051	0.5
Echinococcus granulosus	ryanodine receptor 44f	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Echinococcus granulosus	potassium voltage gated channel protein	0.0017	0.051	0.051
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0017	0.051	0.5
Echinococcus multilocularis	transfer RNA-Gly	0.0017	0.051	0.051
Echinococcus multilocularis	conserved hypothetical protein	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0017	0.051	0.051
Echinococcus granulosus	intermediate filament protein	0.0031	0.4263	0.4263
Brugia malayi	ion channel NompC	0.0017	0.051	0.0076
Schistosoma mansoni	transient receptor potential channel	0.0017	0.0511	0.0000024361
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0017	0.051	0.051
Brugia malayi	voltage-dependent calcium channel	0.0017	0.051	0.0076
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0017	0.051	0.0076
Toxoplasma gondii	hypothetical protein	0.0017	0.051	0.5
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0438	0.0438
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0017	0.051	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0017	0.051	0.051
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0017	0.051	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0017	0.051	0.051
Toxoplasma gondii	transporter, cation channel family protein	0.0017	0.051	0.5
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0017	0.051	0.0076
Echinococcus multilocularis	potassium voltage gated channel protein	0.0017	0.051	0.051
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0017	0.051	0.051
Echinococcus granulosus	transient receptor potential cation channel	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.003	0.4113	0.4113
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0017	0.051	0.0076
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0017	0.051	0.5
Onchocerca volvulus		0.0031	0.4263	1
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0017	0.051	0.051
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0017	0.051	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0017	0.051	0.051
Echinococcus multilocularis	two pore calcium channel protein 2	0.0017	0.051	0.051
Echinococcus granulosus	potassium voltage gated channel protein	0.0017	0.051	0.051
Echinococcus granulosus	two pore calcium channel protein 2	0.0017	0.051	0.051
Echinococcus granulosus	potassium voltage gated channel protein	0.0017	0.051	0.051
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.051	0.051
Schistosoma mansoni	lamin	0.0031	0.4263	0.3955
Echinococcus multilocularis	lamin	0.0031	0.4263	0.4263
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0511	0.0511
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0017	0.051	0.051
Echinococcus granulosus	lamin dm0	0.0031	0.4263	0.4263
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.0511	0.0511
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0017	0.051	0.051
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0017	0.051	0.051
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0017	0.051	0.051
Loa Loa (eye worm)	calcium channel	0.0017	0.051	0.051
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0017	0.051	0.051
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0017	0.051	0.0076
Onchocerca volvulus		0.0031	0.4263	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0017	0.051	0.0076
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0017	0.051	0.051
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0017	0.051	0.0076
Loa Loa (eye worm)	ryanodine receptor	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Toxoplasma gondii	hypothetical protein	0.0017	0.051	0.5
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0017	0.051	0.051
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Echinococcus granulosus	potassium voltage gated channel protein	0.0017	0.051	0.051
Echinococcus granulosus	transient receptor potential cation channel	0.0017	0.051	0.051
Echinococcus granulosus	calcium activated potassium channel	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0017	0.051	0.051
Echinococcus granulosus	voltage gated potassium channel	0.0017	0.051	0.051
Echinococcus granulosus	short transient receptor potential channel 6	0.0017	0.051	0.051
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0017	0.051	0.5
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.4263	0.4001
Echinococcus multilocularis	shaker cognate	0.0017	0.051	0.051
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Echinococcus multilocularis	musashi	0.0031	0.4263	0.4263
Echinococcus granulosus	lamin	0.0031	0.4263	0.4263
Echinococcus multilocularis	two pore calcium channel protein 1	0.0017	0.051	0.051
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0017	0.051	0.051
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0017	0.051	0.051
Echinococcus multilocularis	ryanodine receptor 44f	0.0017	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.051	0.051
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0017	0.051	0.051
Echinococcus multilocularis	sodium channel protein	0.0017	0.051	0.051
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0017	0.051	0.051
Echinococcus granulosus	potassium voltage gated channel protein	0.0017	0.051	0.051
Echinococcus multilocularis	potassium voltage gated channel protein	0.0017	0.051	0.051
Loa Loa (eye worm)	voltage-gated potassium channel	0.0017	0.051	0.051
Brugia malayi	cation channel family protein	0.0017	0.051	0.0076
Echinococcus multilocularis	voltage gated potassium channel	0.0017	0.051	0.051
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0017	0.051	0.051
Loa Loa (eye worm)	voltage-gated calcium channel	0.0017	0.051	0.051
Echinococcus multilocularis	potassium large conductance calcium activated	0.0017	0.051	0.051
Echinococcus multilocularis	short transient receptor potential channel 6	0.0017	0.051	0.051
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0017	0.051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0511	0.0511
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0017	0.051	0.5
Echinococcus granulosus	voltage dependent calcium channel	0.0017	0.051	0.051
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0017	0.051	0.051
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0017	0.051	0.051
Echinococcus granulosus	transient receptor potential cation channel	0.0017	0.0511	0.0511
Echinococcus granulosus	short transient receptor potential channel 6	0.0017	0.051	0.051
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0017	0.051	0.0076
Echinococcus multilocularis	calcium activated potassium channel	0.0017	0.051	0.051
Brugia malayi	olfactory channel protein osm-9	0.0017	0.0511	0.0076
Echinococcus granulosus	transient receptor potential gamma protein	0.0017	0.051	0.051
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0017	0.051	0.0076
Echinococcus granulosus	sodium leak channel non selective protein	0.0017	0.051	0.051
Brugia malayi	hypothetical protein	0.0017	0.051	0.0076

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3120550

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1834517