Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0476 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0476 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0476 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0476 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0476 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0476 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0476 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0476 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0476 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0476 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0476 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0476 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0476 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0476 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0476 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0476 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0476 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0476 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0476 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0476 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0476 | 0.5 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0476 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0476 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0476 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0476 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0476 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0476 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0476 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 56 nM kg-1 | Effective dose of the compound required for the maximum heart rate in anesthetized dogs. | ChEMBL. | 6115058 |
ED50 (functional) | = 71 nM kg-1 | Effective dose of the compound required for the maximum hind limb perfusion pressure(HLPP) in anesthetized dogs. | ChEMBL. | 6115058 |
ISA (functional) | = 82 % | Intrinsic sympathomimetic activity (ISA), calculated as the percent of maximum change in hind limb perfusion pressure (HLPP) | ChEMBL. | 6115058 |
ISA (functional) | = 90 % | Intrinsic sympathomimetic activity (ISA, calculated as the percent of maximum change in heart rate (HR) | ChEMBL. | 6115058 |
Selectivity (functional) | = 1.3 | Selectivity is expressed as the ratio of ED50 on hind limb perfusion pressure to the ED50 on heart rate | ChEMBL. | 6115058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.