Detailed information for compound 183475

Basic information

Technical information
  • TDR Targets ID: 183475
  • Name: [(E)-1-pyrimidin-4-ylethylideneamino]thiourea
  • MW: 195.245 | Formula: C7H9N5S
  • H donors: 1 H acceptors: 2 LogP: 0.47 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N/C(=N/N=C(/c1ccncn1)\C)/S
  • InChi: 1S/C7H9N5S/c1-5(11-12-7(8)13)6-2-3-9-4-10-6/h2-4H,1H3,(H3,8,12,13)/b11-5+
  • InChiKey: CMEFHZLCZDOVTB-VZUCSPMQSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • [(E)-1-(4-pyrimidinyl)ethylideneamino]thiourea
  • 1-[(E)-1-pyrimidin-4-ylethylideneamino]thiourea
  • [(E)-1-(4-pyrimidyl)ethylideneamino]thiourea
  • (1-pyrimidin-4-ylethylideneamino)thiourea
  • [1-(4-pyrimidinyl)ethylideneamino]thiourea
  • AIDS-037994
  • AIDS037994
  • Hydrazinecarbothioamide, 2-[1-(4-pyrimidinyl)ethylidene]-, (2E)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.006 0.0854 0.6932
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Trypanosoma brucei DNA topoisomerase ii 0.005 0.0607 0.566
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0606 0.0406
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0035 0.0228 0.0076
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.006 0.0854 1
Echinococcus multilocularis dna polymerase eta 0.0038 0.0303 0.0378
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0399 0.3718
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0133 0.2711 1
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.1083 0.3495
Echinococcus granulosus nmda type glutamate receptor 0.0083 0.145 0.4962
Trichomonas vaginalis DNA topoisomerase II, putative 0.0064 0.0955 0.0763
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0191 0.178
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1993 0.1822
Trypanosoma cruzi metacaspase, putative 0.005 0.0606 0.3935
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0606 0.0406
Trypanosoma cruzi metacaspase, putative 0.005 0.0606 0.3935
Echinococcus multilocularis caspase 2 0.0097 0.1799 0.6354
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0035 0.0228 0.0076
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Trypanosoma brucei metacaspase MCA2 0.005 0.0606 0.565
Echinococcus granulosus apoptotic protease activating factor 1 0.0047 0.0518 0.1237
Leishmania major metacaspase, putative 0.005 0.0606 0.447
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1993 0.1822
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0046 0.0494 0.2403
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.006 0.0854 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Brugia malayi Cell death protein 3 precursor 0.0097 0.1799 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.0064 0.0955 0.8537
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0035 0.0228 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0057 0.0791 0.7375
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0606 0.4545
Giardia lamblia NADPH oxidoreductase, putative 0.0418 1 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.1098 0.3554
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.1098 0.5315
Brugia malayi hypothetical protein 0.0054 0.0706 0.2693
Schistosoma mansoni glutamate receptor NMDA 0.0035 0.0228 0.0076
Trypanosoma cruzi metacaspase 5, putative 0.005 0.0606 0.3935
Mycobacterium ulcerans DNA polymerase IV 0.0068 0.1073 0.8973
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0606 0.0406
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0874 0.4727
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.005 0.0606 0.2025
Entamoeba histolytica hypothetical protein 0.0105 0.1993 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0047 0.0518 0.1237
Echinococcus multilocularis caspase 0.0133 0.2711 1
Echinococcus granulosus caspase 2 0.0097 0.1799 0.6354
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0105 0.1993 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.1083 0.9396
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0606 0.0406
Giardia lamblia DNA topoisomerase II 0.0061 0.0883 0.0409
Schistosoma mansoni DNA topoisomerase II 0.0064 0.0955 0.2984
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.005 0.0607 0.3949
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.2129
Onchocerca volvulus 0.0047 0.0518 0.0085
Mycobacterium ulcerans DNA polymerase IV 0.0068 0.1073 0.8973
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0054 0.0706 0.2383
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1993 0.1822
Plasmodium vivax DNA topoisomerase II, putative 0.0064 0.0955 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0035 0.0228 0.0076
Entamoeba histolytica DNA topoisomerase II, putative 0.0064 0.0955 0.3859
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0105 0.1993 0.1822
Plasmodium falciparum metacaspase-like protein 0.005 0.0606 0.5323
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.1083 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0303 0.1468
Trypanosoma brucei Metacaspase-4 0.005 0.0606 0.565
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1073 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0399 0.2013
Plasmodium falciparum DNA topoisomerase 2 0.0064 0.0955 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0068 0.1073 1
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0054 0.0706 0.658
Loa Loa (eye worm) hypothetical protein 0.0047 0.0518 0.2694
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0606 0.0406
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0606 0.4545
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0303 0.0378
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1073 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0606 0.0406
Echinococcus granulosus dna polymerase kappa 0.0068 0.1073 0.3454
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1073 1
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0064 0.0955 0.2984
Echinococcus multilocularis dna polymerase kappa 0.0068 0.1073 0.3454
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.1083 0.3495
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0606 0.0406
Echinococcus granulosus dna polymerase eta 0.0038 0.0303 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0303 0.1468
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0399 0.3718
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0054 0.0706 0.5231
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0068 0.1073 0.0883
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1073 1
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0882 0.822
Schistosoma mansoni caspase-7 (C14 family) 0.0133 0.2711 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0068 0.1073 0.0883
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1073 1
Echinococcus multilocularis caspase 3 0.0082 0.1431 0.4883
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.006 0.0854 0.5
Entamoeba histolytica hypothetical protein 0.0054 0.0706 0.2383
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0303 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0314 0.7333 0.7276
Leishmania major DNA topoisomerase ii 0.0057 0.0791 0.6552
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0035 0.0228 0.0076
Leishmania major DNA polymerase eta, putative 0.0038 0.0303 0.1064
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.1083 0.3495
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1993 0.1822
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.1799 0.6354
Trypanosoma brucei metacaspase MCA3 0.005 0.0606 0.565
Echinococcus multilocularis nmda type glutamate receptor 0.0083 0.145 0.4962
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.1098 0.3554
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0064 0.0955 0.4361
Chlamydia trachomatis glutamine binding protein 0.006 0.0854 1
Brugia malayi hypothetical protein 0.0047 0.0518 0.1437
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0068 0.1073 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0606 0.0406
Echinococcus multilocularis glutamate receptor 2 0.0035 0.0228 0.0076
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0418 1 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.1799 1
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0606 0.0406
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0191 0.178
Loa Loa (eye worm) hypothetical protein 0.0054 0.0706 0.3765
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0105 0.1993 0.1822
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1073 1
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0083 0.145 0.4962
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0035 0.0228 0.0076
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.1083 0.9835
Trypanosoma cruzi DNA polymerase kappa, putative 0.0068 0.1073 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.1083 0.9396
Trypanosoma brucei metacaspase 0.005 0.0606 0.565
Trypanosoma cruzi DNA topoisomerase II, putative 0.0057 0.0791 0.6341
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.1083 0.3495
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1993 0.1822
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Plasmodium vivax hypothetical protein, conserved 0.005 0.0606 0.5323
Trypanosoma cruzi metacaspase, putative 0.005 0.0606 0.3935
Schistosoma mansoni hypothetical protein 0.0047 0.0518 0.1237
Leishmania major mitochondrial DNA topoisomerase II 0.005 0.0607 0.4481
Trypanosoma brucei DNA polymerase IV, putative 0.0068 0.1073 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.005 0.0606 0.4545
Trypanosoma cruzi metacaspase 5, putative 0.005 0.0606 0.3935
Trypanosoma cruzi DNA polymerase kappa, putative 0.0068 0.1073 1
Echinococcus granulosus glutamate receptor 2 0.0035 0.0228 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0054 0.0706 0.5231
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0606 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1993 0.1822
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0303 0.0378
Plasmodium vivax metacaspase 1, putative 0.005 0.0606 0.5323
Loa Loa (eye worm) hypothetical protein 0.005 0.0606 0.3196
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0303 0.2827
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.005 0.0607 0.3949
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.1098 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.1083 0.9396
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.2129
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0133 0.2711 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0606 0.0406
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Trypanosoma cruzi DNA polymerase kappa, putative 0.0068 0.1073 1
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0105 0.1993 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0606 0.0406
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0035 0.0228 0.0076
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0105 0.1993 0.1822
Trichomonas vaginalis conserved hypothetical protein 0.0418 1 1
Schistosoma mansoni caspase-3 (C14 family) 0.0133 0.2711 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0303 0.0378
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1073 1
Trypanosoma cruzi metacaspase, putative 0.005 0.0606 0.3935
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0606 0.0406
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0418 1 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0064 0.0955 0.4361
Echinococcus multilocularis caspase 8 0.005 0.0606 0.1588
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0191 0.178
Trypanosoma brucei metacaspase 5, putative 0.005 0.0606 0.565
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.1098 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0606 0.0406
Loa Loa (eye worm) TOPoisomerase family member 0.0064 0.0955 0.5188
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1073 1
Echinococcus granulosus caspase 0.0133 0.2711 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0057 0.0791 0.6341
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.005 0.0606 0.0406
Trypanosoma brucei unspecified product 0.0061 0.0882 0.822
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.1098 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0046 0.0494 0.3211
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.1083 0.9815
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1993 0.1822
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0064 0.0955 0.2984
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1993 0.1822
Brugia malayi Probable DNA topoisomerase II 0.0064 0.0955 0.4361
Leishmania major DNA polymerase kappa, putative 0.0046 0.0494 0.3211
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.1098 1
Giardia lamblia NADPH oxidoreductase, putative 0.0418 1 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.1098 0.3554
Echinococcus granulosus caspase 3 0.0082 0.1431 0.4883
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1993 0.1822
Plasmodium falciparum metacaspase 1 0.005 0.0606 0.5323
Onchocerca volvulus Cell death protein 3 homolog 0.0097 0.1799 1
Schistosoma mansoni DNA polymerase eta 0.0038 0.0303 0.0378
Echinococcus granulosus caspase 8 0.005 0.0606 0.1588
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0418 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0105 0.1993 0.1822
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0035 0.0228 0.0076
Brugia malayi polk-prov protein 0.0042 0.0399 0.0639
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0057 0.0791 0.7375
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1073 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.005 0.0606 0.1588
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0494 0.4607

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.14 ug ml-1 Inhibition of HIV-1-induced cytopathic effect in MT-4 cells. ChEMBL. 1354751
ED50 (functional) = 0.14 ug ml-1 Inhibition of HIV-1-induced cytopathic effect in MT-4 cells. ChEMBL. 1354751
ED50 (functional) = 0.82 ug ml-1 Inhibition of Herpes simplex virus-1 (HSV-1)-induced cytopathic effect in HUT78 cells. ChEMBL. 1354751
ED50 (functional) = 0.82 ug ml-1 Inhibition of Herpes simplex virus-1 (HSV-1)-induced cytopathic effect in HUT78 cells. ChEMBL. 1354751

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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