Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0168 | 0.0227 | 0.0213 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.0021 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0027 | 0.0282 |
Loa Loa (eye worm) | thymidylate synthase | 0.064 | 0.098 | 0.098 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0305 | 0.0445 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3209 | 0.5076 | 1 |
Brugia malayi | hypothetical protein | 0.0305 | 0.0445 | 0.0445 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.0021 | 0.0013 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3209 | 0.5076 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.064 | 0.098 | 0.0967 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3209 | 0.5076 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.014 | 0.0182 | 0.0168 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0144 | 0.0189 | 0.0174 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.0027 | 0.0024 |
Brugia malayi | thymidylate synthase | 0.064 | 0.098 | 0.098 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.0027 | 0.0024 |
Onchocerca volvulus | 0.064 | 0.098 | 0.5 | |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0144 | 0.0189 | 0.0174 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3209 | 0.5076 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.064 | 0.098 | 0.0967 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3209 | 0.5076 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0227 | 0.0213 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0144 | 0.0189 | 0.0189 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0305 | 0.0445 | 0.085 |
Loa Loa (eye worm) | ICD-1 protein | 0.0035 | 0.0014 | 0.0014 |
Echinococcus granulosus | thymidylate synthase | 0.064 | 0.098 | 0.0967 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0027 | 0.0282 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.0027 | 0.0024 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.064 | 0.098 | 0.056 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.0021 | 1 |
Brugia malayi | beta-NAC-like protein | 0.0035 | 0.0014 | 0.0014 |
Echinococcus granulosus | geminin | 0.0168 | 0.0227 | 0.0213 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3209 | 0.5076 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0227 | 0.0213 |
Loa Loa (eye worm) | acetyltransferase | 0.0144 | 0.0189 | 0.0189 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0027 | 0.0012 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9.35 uM | Cytotoxicity against human KB cells after 72 hrs by SRB assay | ChEMBL. | 24553146 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24553146 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.