Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcitonin receptor-like | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | calcitonin receptor-like | 461 aa | 434 aa | 28.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0607 | 0.3141 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0607 | 0.3141 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0607 | 0.3141 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0607 | 0.3141 | 0.3141 |
Echinococcus granulosus | dihydrofolate reductase | 0.1204 | 0.6912 | 0.6912 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1204 | 0.6912 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0607 | 0.3141 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0117 | 0.0048 | 0.0048 |
Onchocerca volvulus | 0.0117 | 0.0048 | 1 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0117 | 0.0048 | 0.0069 |
Schistosoma mansoni | dihydrofolate reductase | 0.1204 | 0.6912 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0117 | 0.0048 | 0.0048 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0117 | 0.0048 | 0.0069 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1204 | 0.6912 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.1204 | 0.6912 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1204 | 0.6912 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0607 | 0.3141 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1204 | 0.6912 | 0.6912 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1204 | 0.6912 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1204 | 0.6912 | 1 |
Brugia malayi | thymidylate synthase | 0.0117 | 0.0048 | 0.0069 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1204 | 0.6912 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.16 uM | Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production preincubated for 30 mins followed by CGRP addition measured after 3 hrs by beta-lactamase reporter gene-based FRET assay | ChEMBL. | 24405707 |
Ki (binding) | = 0.052 uM | Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cell membranes preincubated for 30 mins followed by radioligand addition measured after 2 hrs by liquid scintillation counting | ChEMBL. | 24405707 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.