Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | SH2 domain containing protein | 0.2367 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.2367 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.2367 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2367 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2367 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.2367 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2367 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.2367 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.2367 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.2367 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.2367 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.2367 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.2367 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.2367 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2367 | 0.5 | 0.5 | |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.2367 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2367 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.2367 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2367 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.2367 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2367 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2367 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine kinase | 0.2367 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.2367 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2367 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.2367 | 0.5 | 0.5 |
Onchocerca volvulus | 0.2367 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.2367 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 72 nM | In vitro inhibition of potassium-contracted rabbit aorta strips | ChEMBL. | 1387168 |
Max/average (functional) | = 0 | In vivo evaluation for the antihypertensive effect in the spontaneously hypertensive rat is % decrease in blood pressure during post drug administration at 135 umol/kg peroral; 28/23 | ChEMBL. | 1387168 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.