Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0252 | 0.2545 | 0.2545 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0252 | 0.2545 | 0.2545 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0252 | 0.2545 | 0.2545 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3343 | 0.3343 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3343 | 0.3343 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3343 | 0.3343 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0282 | 0.3343 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0282 | 0.3343 | 0.3343 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0252 | 0.2545 | 0.2545 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0252 | 0.2545 | 0.2545 |
Loa Loa (eye worm) | DR-78 | 0.0252 | 0.2545 | 0.2545 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0282 | 0.3343 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0282 | 0.3343 | 0.3343 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0252 | 0.2545 | 0.2545 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0252 | 0.2545 | 0.2545 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0252 | 0.2545 | 0.2545 |
Brugia malayi | nuclear receptor RXR | 0.0282 | 0.3343 | 0.1071 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0252 | 0.2545 | 0.2545 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0282 | 0.3343 | 0.3343 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0252 | 0.2545 | 0.2545 |
Schistosoma mansoni | nuclear hormone receptor | 0.0252 | 0.2545 | 0.2545 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0252 | 0.2545 | 0.2545 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0252 | 0.2545 | 0.2545 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0252 | 0.2545 | 0.2545 |
Schistosoma mansoni | nuclear receptor | 0.0252 | 0.2545 | 0.2545 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3343 | 0.3343 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0252 | 0.2545 | 0.2545 |
Brugia malayi | hypothetical protein | 0.0282 | 0.3343 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0252 | 0.2545 | 0.2545 |
Schistosoma mansoni | nuclear hormone receptor | 0.0252 | 0.2545 | 0.2545 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0282 | 0.3343 | 0.3343 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.3343 | 0.3343 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0252 | 0.2545 | 0.2545 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0252 | 0.2545 | 0.2545 |
Brugia malayi | hypothetical protein | 0.0282 | 0.3343 | 0.1071 |
Schistosoma mansoni | zinc finger protein | 0.0252 | 0.2545 | 0.2545 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0282 | 0.3343 | 0.3343 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0252 | 0.2545 | 0.2545 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.2545 | 0.2545 |
Schistosoma mansoni | nuclear receptor | 0.0252 | 0.2545 | 0.2545 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 522.1 nM | Displacement of [3H]spiperone from dopamine D2 receptor in Sprague-Dawley rat striatum homogenate after 30 mins by liquid scintillation counting | ChEMBL. | 24487191 |
Ki (binding) | = 653.1 nM | Displacement of [3H]Ketanserin from 5HT2A receptor in Sprague-Dawley rat brain cortex homogenate after 30 mins by liquid scintillation counting | ChEMBL. | 24487191 |
Ki (binding) | = 968.6 nM | Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Sprague-Dawley rat brain cortex homogenate after 30 mins by liquid scintillation counting | ChEMBL. | 24487191 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.