Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0676 | 0.6669 | 0.5 |
Chlamydia trachomatis | biotin carboxylase | 0.0323 | 0.2114 | 0.5 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0495 | 0.4337 | 0.3894 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0184 | 0.032 | 1 |
Echinococcus multilocularis | 0.0399 | 0.31 | 0.1555 | |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0301 | 0.1829 | 0.5 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0356 | 0.2536 | 0.5 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0356 | 0.2536 | 0.5 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0356 | 0.2536 | 0.1953 |
Brugia malayi | celfurPC protein | 0.0399 | 0.31 | 0.1495 |
Echinococcus granulosus | furin | 0.0495 | 0.4337 | 0.3069 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0676 | 0.6669 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0495 | 0.4337 | 0.4257 |
Brugia malayi | endoprotease bli-4 precursor | 0.0495 | 0.4337 | 0.3119 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0495 | 0.4337 | 0.4257 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0901 | 0.9578 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0578 | 0.5408 | 1 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0356 | 0.2536 | 0.5 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0356 | 0.2536 | 0.5 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0356 | 0.2536 | 0.1953 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0356 | 0.2536 | 0.0865 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0301 | 0.1829 | 0.5 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0311 | 0.1961 | 0.0162 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0901 | 0.9578 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0356 | 0.2536 | 0.5 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0356 | 0.2536 | 0.0865 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0356 | 0.2536 | 0.1741 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0356 | 0.2536 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0356 | 0.2536 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0356 | 0.2536 | 0.1741 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0311 | 0.1961 | 0.0162 |
Schistosoma mansoni | pyruvate carboxylase | 0.0356 | 0.2536 | 0.1953 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0356 | 0.2536 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
permeability (ADMET) | = 6.3 ucm/s | Permeability from apical to basolateral side of human Caco2 cells | ChEMBL. | 23506530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.