Detailed information for compound 183558

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 550.639 | Formula: C32H38O8
  • H donors: 6 H acceptors: 6 LogP: 6.88 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: COc1c(c(C)cc2c1c(CO)c(O)c(c2C(C)C)O)c1c(C)cc2c(c1OC)c(CO)c(c(c2C(C)C)O)O
  • InChi: 1S/C32H38O8/c1-13(2)21-17-9-15(5)23(31(39-7)25(17)19(11-33)27(35)29(21)37)24-16(6)10-18-22(14(3)4)30(38)28(36)20(12-34)26(18)32(24)40-8/h9-10,13-14,33-38H,11-12H2,1-8H3
  • InChiKey: RIZZFSBARAUMFG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldo-keto reductase family 1, member B1 (aldose reductase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Conserved protein aldo-keto reductase family 1, member B1 (aldose reductase) 316 aa 325 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0067 0.2688 0.1716
Loa Loa (eye worm) hypothetical protein 0.0067 0.2688 0.2387
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.1174 0.5
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0205 1 1
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0054 0.203 0.6337
Mycobacterium tuberculosis Polyketide synthase Pks2 0.005 0.1778 0.5551
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0018 0.008 0.0251
Echinococcus granulosus aldo keto reductase 0.0038 0.1174 0.0623
Mycobacterium ulcerans polyketide synthase Pks9 0.0034 0.0942 0.2941
Echinococcus granulosus hypothetical protein 0.0038 0.1174 0.0623
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.1174 0.5
Schistosoma mansoni hypothetical protein 0.0067 0.2688 0.1716
Schistosoma mansoni caspase-7 (C14 family) 0.0067 0.2688 0.1716
Loa Loa (eye worm) hypothetical protein 0.0029 0.0668 0.0284
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1174 0.0623
Onchocerca volvulus 0.0205 1 1
Mycobacterium ulcerans thioesterase TesA 0.0043 0.1409 0.4398
Leishmania major prostaglandin f synthase, putative 0.0038 0.1174 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1174 0.0623
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1174 0.0623
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0205 1 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.1174 0.081
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.005 0.1778 0.5551
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1174 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1174 0.5
Loa Loa (eye worm) hypothetical protein 0.0205 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.1174 0.5
Echinococcus granulosus aldo keto reductase 0.0038 0.1174 0.0623
Mycobacterium ulcerans polyketide synthase Pks13 0.0077 0.3203 1
Trypanosoma cruzi aldo-keto reductase 0.0038 0.1174 0.5
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0048 0.1683 0.5254
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0033 0.0908 0.2574
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.1174 0.5
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0043 0.1409 0.4398
Echinococcus multilocularis aldo keto reductase 0.0038 0.1174 0.0623
Giardia lamblia Aldose reductase 0.0038 0.1174 0.5
Echinococcus granulosus inhibitor of apoptosis protein 0.0205 1 1
Onchocerca volvulus 0.0089 0.3871 0.3056
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1174 0.0623
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0054 0.203 0.6337
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0051 0.1861 0.581
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1174 0.5
Giardia lamblia Aldose reductase 0.0038 0.1174 0.5
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0097 0.4291 0.3532
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0051 0.1861 0.581
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1174 0.0623
Entamoeba histolytica aldose reductase, putative 0.0038 0.1174 0.5
Schistosoma mansoni hypothetical protein 0.0205 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1174 0.0623
Onchocerca volvulus Cell death protein 3 homolog 0.0067 0.2688 0.1716
Toxoplasma gondii type I fatty acid synthase, putative 0.0054 0.203 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0048 0.1683 0.1341
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1174 0.5
Echinococcus multilocularis aldo keto reductase 0.0038 0.1174 0.0623
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1174 0.0623
Entamoeba histolytica aldose reductase, putative 0.0038 0.1174 0.5
Echinococcus multilocularis aldo keto reductase 0.0038 0.1174 0.0623
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.1174 0.5
Onchocerca volvulus 0.0048 0.1683 0.0577
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1174 0.0623
Mycobacterium leprae Polyketide synthase Pks13 0.0077 0.3203 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.1174 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.1174 0.081
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0077 0.3203 1
Loa Loa (eye worm) hypothetical protein 0.0205 1 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0041 0.1331 0.4155
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.1861 0.581
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1174 0.5
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0054 0.203 0.6337
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1174 0.0623
Loa Loa (eye worm) oxidoreductase 0.0038 0.1174 0.081
Toxoplasma gondii aldose reductase, putative 0.0038 0.1174 0.4333
Loa Loa (eye worm) hypothetical protein 0.0086 0.3706 0.3447
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1174 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0054 0.203 0.6337
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0029 0.069 0.2155
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0037 0.1097 0.3424
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1174 0.0623
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0051 0.1861 0.581
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1174 0.0623
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1174 0.0623
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0077 0.3203 1
Mycobacterium ulcerans thioesterase 0.0043 0.1409 0.4398
Leishmania major aldo-keto reductase-like protein 0.0038 0.1174 0.5
Echinococcus granulosus apoptotic protease activating factor 1 0.0067 0.2688 0.2232
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0051 0.1861 0.581
Mycobacterium ulcerans polyketide synthase 0.0054 0.203 0.6337
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0205 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1174 0.5
Loa Loa (eye worm) oxidoreductase 0.0038 0.1174 0.081
Echinococcus multilocularis caspase 2 0.0067 0.2688 0.2232
Loa Loa (eye worm) oxidoreductase 0.0038 0.1174 0.081
Loa Loa (eye worm) oxidoreductase 0.0038 0.1174 0.081
Onchocerca volvulus 0.0067 0.2688 0.1716
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1174 0.0623
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0034 0.0942 0.2941
Schistosoma mansoni inhibitor of apoptosis protein 0.0205 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1174 0.0623
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0054 0.203 0.6337
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1174 0.5
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.1861 0.581
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.1174 0.5
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.1174 0.3664
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1174 0.0623
Toxoplasma gondii type I fatty acid synthase, putative 0.0036 0.1079 0.3708
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.1174 0.5
Loa Loa (eye worm) fatty acid synthase 0.0051 0.1825 0.1488
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0051 0.1861 0.581
Echinococcus granulosus aldo keto reductase 0.0038 0.1174 0.0623
Mycobacterium tuberculosis Probable thioesterase TesA 0.0043 0.1409 0.4398
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1174 0.0623
Brugia malayi Cell death protein 3 precursor 0.0067 0.2688 0.1716
Trypanosoma brucei prostaglandin f synthase 0.0038 0.1174 0.5
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.1174 0.5
Echinococcus multilocularis apoptotic protease activating factor 1 0.0067 0.2688 0.2232
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.1174 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1174 0.0623
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0041 0.1331 0.4155
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1174 0.5
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.1861 0.581
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1174 0.0623
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0054 0.203 0.6337
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1174 0.5
Onchocerca volvulus Fatty acid synthase homolog 0.0092 0.4039 0.3247
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0034 0.0942 0.2941
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.1174 0.0623
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0051 0.1861 0.0779
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.0587 0.1832
Mycobacterium ulcerans oxidoreductase 0.0038 0.1174 0.3664
Loa Loa (eye worm) hypothetical protein 0.0067 0.2688 0.2387
Echinococcus granulosus caspase 2 0.0067 0.2688 0.2232
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1174 0.5
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0054 0.203 0.6337
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.1174 0.3664
Echinococcus multilocularis inhibitor of apoptosis protein 0.0205 1 1
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0205 1 1
Echinococcus multilocularis aldo keto reductase 0.0038 0.1174 0.0623
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.1174 0.0623
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0041 0.1331 0.4155
Mycobacterium ulcerans polyketide synthase 0.0051 0.1861 0.581
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0051 0.1861 0.581
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0021 0.0245 0.0765
Brugia malayi AMP-binding enzyme family protein 0.0048 0.1683 0.0577
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0042 0.1367 0.4267
Entamoeba histolytica aldose reductase, putative 0.0038 0.1174 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.1174 0.5
Mycobacterium leprae Probable polyketide synthase Pks1 0.0054 0.203 0.6337
Onchocerca volvulus Deterin homolog 0.0205 1 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 4.3 uM The compound was tested for inhibitory activity against Aldose reductase from human placenta ChEMBL. 1956050
Ki (binding) = 4.3 uM The compound was tested for inhibitory activity against Aldose reductase from human placenta ChEMBL. 1956050

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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