Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epoxide hydrolase 2, cytoplasmic | Starlite/ChEMBL | References |
Rattus norvegicus | Epoxide hydrolase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Mycobacterium ulcerans | epoxide hydrolase EphA | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0935 | 0.4058 | 0.3659 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0935 | 0.4058 | 0.3659 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1259 | 0.6492 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0479 | 0.063 | 0.063 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0935 | 0.4058 | 0.3659 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0935 | 0.4058 | 0.3659 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1259 | 0.6492 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1259 | 0.6492 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0935 | 0.4058 | 0.3659 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1259 | 0.6492 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0935 | 0.4058 | 0.3659 |
Schistosoma mansoni | P2X receptor subunit | 0.0935 | 0.4058 | 0.3659 |
Schistosoma mansoni | P2X receptor subunit | 0.0935 | 0.4058 | 0.3659 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0935 | 0.4058 | 0.3659 |
Onchocerca volvulus | 0.0479 | 0.063 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1259 | 0.6492 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0935 | 0.4058 | 0.3659 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1259 | 0.6492 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0479 | 0.063 | 0.063 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CLH (ADMET) | < 0.01 ml/min | Intrinsic clearance in human liver microsomes measured per mg of protein at 1 uM after 30 mins by LC/MS/MS analysis | ChEMBL. | 24530032 |
IC50 (binding) | > 100 nM | Inhibition of rat recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay | ChEMBL. | 24530032 |
IC50 (binding) | > 100 nM | Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay | ChEMBL. | 24530032 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.