Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0332 | 0.026 | 0.026 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.1532 | 0.6697 | 0.6697 |
Brugia malayi | Protein kinase c protein 2 | 0.1823 | 0.8257 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0332 | 0.026 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0332 | 0.026 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0332 | 0.026 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0334 | 0.0267 | 0.0336 |
Trichomonas vaginalis | AGC family protein kinase | 0.0332 | 0.026 | 1 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0332 | 0.026 | 0.026 |
Brugia malayi | Dihydrofolate reductase | 0.1203 | 0.4931 | 0.5841 |
Brugia malayi | dihydrofolate reductase family protein | 0.1203 | 0.4931 | 0.5841 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0878 | 0.3185 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0332 | 0.026 | 0.026 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0332 | 0.026 | 0.0327 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0616 | 0.1782 | 0.1782 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0332 | 0.026 | 0.026 |
Entamoeba histolytica | protein kinase, putative | 0.0332 | 0.026 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0332 | 0.026 | 0.026 |
Brugia malayi | protein kinase C II. | 0.0616 | 0.1782 | 0.1903 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0878 | 0.3185 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0332 | 0.026 | 0.026 |
Echinococcus granulosus | dihydrofolate reductase | 0.1203 | 0.4931 | 0.4931 |
Echinococcus multilocularis | protein kinase c iota type | 0.0567 | 0.152 | 0.152 |
Brugia malayi | thymidylate synthase | 0.0334 | 0.0267 | 0.0009 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.1588 | 0.6997 | 0.8794 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1203 | 0.4931 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0567 | 0.152 | 0.152 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1203 | 0.4931 | 0.4931 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1203 | 0.4931 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0332 | 0.026 | 1 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0332 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0332 | 0.026 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.1532 | 0.6697 | 0.6697 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0332 | 0.026 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.026 | 0.0327 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0332 | 0.026 | 0.026 |
Entamoeba histolytica | protein kinase, putative | 0.0332 | 0.026 | 0.5 |
Echinococcus multilocularis | serine threonine protein kinase | 0.1913 | 0.874 | 0.874 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1203 | 0.4931 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0332 | 0.026 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.1532 | 0.6697 | 0.6697 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0878 | 0.3185 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1203 | 0.4931 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0616 | 0.1782 | 0.2239 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0878 | 0.3185 | 0.5 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0332 | 0.026 | 0.0327 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0878 | 0.3185 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1203 | 0.4931 | 0.4931 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0332 | 0.026 | 0.026 |
Echinococcus granulosus | thymidylate synthase | 0.0334 | 0.0267 | 0.0267 |
Entamoeba histolytica | protein kinase, putative | 0.0332 | 0.026 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.1913 | 0.874 | 0.874 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0334 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0332 | 0.026 | 0.0327 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0332 | 0.026 | 0.026 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0332 | 0.026 | 0.026 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0332 | 0.026 | 0.026 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0878 | 0.3185 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0332 | 0.026 | 1 |
Onchocerca volvulus | 0.0334 | 0.0267 | 1 | |
Echinococcus granulosus | protein kinase c iota type | 0.0567 | 0.152 | 0.152 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0332 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0332 | 0.026 | 1 |
Echinococcus granulosus | NDR protein kinase | 0.0332 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0332 | 0.026 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1532 | 0.6697 | 0.8417 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0616 | 0.1782 | 0.1782 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0332 | 0.026 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.1767 | 0.7957 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1203 | 0.4931 | 0.6197 |
Echinococcus multilocularis | thymidylate synthase | 0.0334 | 0.0267 | 0.0267 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0332 | 0.026 | 0.026 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0616 | 0.1782 | 0.1782 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0332 | 0.026 | 0.0327 |
Trichomonas vaginalis | AGC family protein kinase | 0.0332 | 0.026 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0332 | 0.026 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0332 | 0.026 | 0.026 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0332 | 0.026 | 0.0327 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.