Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0249 | 0.593 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.5968 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 0.3073 | 0.3073 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.5968 | 0.5968 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.5968 | 0.5968 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.1011 | 0.1011 |
Echinococcus multilocularis | thymidylate synthase | 0.0124 | 0.2719 | 0.2719 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.5968 | 0.5968 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0001 | 0.0001 |
Brugia malayi | dihydrofolate reductase family protein | 0.0249 | 0.593 | 0.593 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.1011 | 0.1011 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0249 | 0.593 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0249 | 0.593 | 0.593 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0543 | 0.0543 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Onchocerca volvulus | 0.0124 | 0.2719 | 0.5 | |
Brugia malayi | MH2 domain containing protein | 0.0138 | 0.3073 | 0.3073 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Echinococcus granulosus | dihydrofolate reductase | 0.0249 | 0.593 | 0.593 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0059 | 0.1048 | 0.1048 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 0.3073 | 0.3073 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0251 | 0.5968 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0249 | 0.593 | 0.593 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0059 | 0.1048 | 0.1767 |
Brugia malayi | thymidylate synthase | 0.0124 | 0.2719 | 0.2719 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0543 | 0.0543 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0249 | 0.593 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Schistosoma mansoni | dihydrofolate reductase | 0.0249 | 0.593 | 0.593 |
Echinococcus granulosus | thymidylate synthase | 0.0124 | 0.2719 | 0.2719 |
Brugia malayi | Dihydrofolate reductase | 0.0249 | 0.593 | 0.593 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0543 | 0.0543 |
Loa Loa (eye worm) | thymidylate synthase | 0.0124 | 0.2719 | 0.2719 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1011 | 0.1011 |
Brugia malayi | hypothetical protein | 0.0059 | 0.1048 | 0.1048 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.5968 | 0.5968 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0124 | 0.2719 | 0.2719 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0249 | 0.593 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.1011 | 0.1011 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0124 | 0.2719 | 0.4585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.