Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase A | Starlite/ChEMBL | References |
Homo sapiens | monoamine oxidase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase A | 527 aa | 474 aa | 22.4 % |
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase B | 520 aa | 462 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0354 | 0.3153 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.3153 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0354 | 0.3153 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0354 | 0.3153 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0354 | 0.3153 | 1 |
Onchocerca volvulus | 0.0354 | 0.3153 | 0.5 | |
Brugia malayi | nuclear hormone receptor | 0.0354 | 0.3153 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0354 | 0.3153 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0354 | 0.3153 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.3153 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0354 | 0.3153 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0354 | 0.3153 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0354 | 0.3153 | 1 |
Brugia malayi | steroid hormone receptor | 0.0354 | 0.3153 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0354 | 0.3153 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0354 | 0.3153 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0354 | 0.3153 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0354 | 0.3153 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0354 | 0.3153 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0354 | 0.3153 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0354 | 0.3153 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0354 | 0.3153 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0354 | 0.3153 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0354 | 0.3153 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0354 | 0.3153 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0354 | 0.3153 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0354 | 0.3153 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0354 | 0.3153 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0354 | 0.3153 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0354 | 0.3153 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0354 | 0.3153 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0354 | 0.3153 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0354 | 0.3153 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0354 | 0.3153 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0354 | 0.3153 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0354 | 0.3153 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0667 | 0.9047 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.3153 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0354 | 0.3153 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0354 | 0.3153 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0354 | 0.3153 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.3153 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0354 | 0.3153 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0354 | 0.3153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.3153 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 535 nM | Inhibition of human recombinant MAO-B expressed in baculovirus infected insect cells assessed as hydrogen peroxide production using p-tyramine as substrate incubated for 30 mins prior to substrate addition measured for 45 mins by Amplex Red monoamine oxidase assay | ChEMBL. | 24560738 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant MAO-A expressed in baculovirus infected insect cells assessed as hydrogen peroxide production using p-tyramine as substrate incubated for 30 mins prior to substrate addition measured for 45 mins by Amplex Red monoamine oxidase assay | ChEMBL. | 24560738 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.