Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor RXR | 0.0022 | 0.2661 | 0.2661 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2661 | 0.2661 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | conserved hypotetical protein | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | DR-78 | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | nuclear receptor RXR | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | Nuclear hormone receptor E75 | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | Nuclear hormone receptor E75 | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | hypothetical protein | 0.0022 | 0.2661 | 0.2661 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0022 | 0.2661 | 0.1071 |
Brugia malayi | tailless protein | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2661 | 0.2661 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2661 | 0.2661 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0022 | 0.2661 | 0.2661 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2661 | 0.2661 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0.2661 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2661 | 0.2661 |
Brugia malayi | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | ecdysone receptor | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.2661 | 0.2661 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0022 | 0.2661 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.2661 | 0.2661 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | nuclear receptor NHR-67 | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.002 | 0.1781 | 0.1781 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0022 | 0.2661 | 0.1071 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.002 | 0.1781 | 0.1781 |
Brugia malayi | hypothetical protein | 0.0022 | 0.2661 | 0.2661 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 0.46 uM | Inhibition of human CYP3A4-mediated midazolam 1'-hydroxylase activity | ChEMBL. | 24411125 |
IC50 (ADMET) | = 0.5 uM | Inhibition of human CYP3A4-mediated midazolam 1'-hydroxylase activity | ChEMBL. | 24411125 |
IC50 (binding) | > 30 uM | Inhibition of HIV-1 protease | ChEMBL. | 24411125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.